Hexaprofen, a potent anti-inflammatory agent, is an inhibitor of platelet aggregation. Experiments on mice have shown that hexaprofen could reduce the quantity and size of Lewis lung carcinoma (LLC) tumor nodules.

Oxepinac was developed as an anti-inflammatory drug. Results of clinical trials have revealed that oxepinac was an effective and well-tolerated drug in the treatment of painful osteoarthritis. Experiments on animal have shown that oxepinac had no teratogenic effect on fetuses in mice and rabbits. Information about the current use of this drug is not available.

Sumacetamol is a acetylaminothioalkanoate derivative patented by Sterwin A.-G. as an analgesic and antipyretic agent. Sumacetamol is used in combination with free paracetamol. In clinical trials, Sumacetamol failed to demonstrate superior efficacy in pain and swelling management compare to paracetamol but shows a longer duration of analgesia. The rates of reported adverse events were similar in paracetamol and Sumacetamol, although reports of mild to moderate drowsiness were more common after the Sumacetamol combination.

Fenclorac is a potent nonsteroidal anti-inflammatory agent with significant analgesic and antipyretic activity. It inhibits prostaglandin synthesis both in vitro and in vivo.

Anidoxime is unrelated to other analgesic agents in clinical use. It is the hydrochloride salt of 0-(4-methoxyphenyl-carboxyl)-3-diethylamino-propiophenone oxime, with an empirical formula C21H27N3O3 HCl. It was in clinical trial as an oral analgesic agent.

Clonixeril is a glyceryl ester of a nonsteroid anti-inflammatory drug clonixin, developed by Scherico Ltd in the 1970s. Oral administration of clonixeril delays the onset of castor oil-induced diarrhoea in rats.

ALFETAMINE (aletamine) is an antidepressant and analgesic. The pharmacologic activity profile of aletamine closely resembles that of the tricyclic antidepressants imipramine and amitriptyline. Effects shared are antagonism of RO4-1284-induced ptosis and depressed exploratory behavior, depression of spontaneous motor activity, prolongation of hexobarbital hypnosis and anticonvulsant action in mice, hypotension and potentiation of norepinephrine pressor effects in dogs, antimuricidal effects, hypothermia in rats and local anesthesia in rabbits and guinea pigs. Aletamine differed from imipramine and amitriptyline as follows: (1) aletamine exerted no apparent central or peripheral anticholinergic effect as suggested by lack of influence on tremorine-induced tremors or salivation; (2) although aletamine was less potent on a milligram basis than imipramine and amitriptyline in preventing RO4-1284 depression, aletamine was more potent than imipramine in counteracting existing reserpine depression (ptosis, depressed exploratory behavior) in mice. Amitriptyline was inactive against reserpine depression. The pharmacologic effects of aletamine differ in several respects from those of d-amphetamine. The effects of aletamine on spontaneous motor activity, hexobarbital hypnosis and body temperature in rodents and on blood pressure in dogs are in opposite direction to those of amphetamine. In further contrast to amphetamine, grouping of mice has no influence on the toxicity of aletamine. Aletamine does not appear to be an inhibitor of monoamine oxidase in vivo since it does not enhance tryptamine-induced convulsions in rats.

FLUCARBRIL, a quinoline derivative, is a drug with a muscle relaxant, analgesic, and anti-inflammatory properties.

Molinazone is a benzotriazinone derivative patented by chemical and pharmaceutical companies Farbenfabriken Bayer A.-G. and Bristol-Myers Co. as an analgesic and muscle relaxant

Prifelone (also known as R-830) is a thiophene derivative patented by American pharmaceutical company Riker Laboratories, Inc. As an antiinflammatory, analgesic, and antipyretic compound. In vitro, Prifelone acts as a nonsteroidal anti-inflammatory drug and inhibits guinea pig lung lipoxygenase and bovine seminal vesicle cyclooxygenase. In preclinical studies, Prifelone shows potent anti-inflammatory activity in carrageenan-induced edema and adjuvant arthritis of the rat and ultraviolet-induced erythema in the guinea pig