PRIFELONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24O2S
Molecular Weight	316.458
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(=O)C2=CC=CS2

InChI

InChIKey=WAAVMZLJRXYRMA-UHFFFAOYSA-N

InChI=1S/C19H24O2S/c1-18(2,3)13-10-12(16(20)15-8-7-9-22-15)11-14(17(13)21)19(4,5)6/h7-11,21H,1-6H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6819772 | https://www.ncbi.nlm.nih.gov/pubmed/2825479

Prifelone (also known as R-830) is a thiophene derivative patented by American pharmaceutical company Riker Laboratories, Inc. As an antiinflammatory, analgesic, and antipyretic compound. In vitro, Prifelone acts as a nonsteroidal anti-inflammatory drug and inhibits guinea pig lung lipoxygenase and bovine seminal vesicle cyclooxygenase. In preclinical studies, Prifelone shows potent anti-inflammatory activity in carrageenan-induced edema and adjuvant arthritis of the rat and ultraviolet-induced erythema in the guinea pig

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Name

Type

Language

PRIFELONE

Official Name

English

PRIFELONE [USAN]

Common Name

English

R-830

Code

English

3,5-Di-tert-butyl-4-hydroxyphenyl 2-thienyl ketone

Systematic Name

English

R-830T

Code

English

prifelone [INN]

Common Name

English

METHANONE, (3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL)-2-THIENYL-

Systematic Name

English

S-16820

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C257