SUMACETAMOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H20N2O4S
Molecular Weight	324.395
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSCCC(NC(C)=O)C(=O)OC1=CC=C(NC(C)=O)C=C1

InChI

InChIKey=GDRGOYFISYGSHQ-UHFFFAOYSA-N

InChI=1S/C15H20N2O4S/c1-10(18)16-12-4-6-13(7-5-12)21-15(20)14(8-9-22-3)17-11(2)19/h4-7,14H,8-9H2,1-3H3,(H,16,18)(H,17,19)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3780826 | https://www.ncbi.nlm.nih.gov/pubmed/1639228 | https://www.ncbi.nlm.nih.gov/pubmed/6468471 | https://www.ncbi.nlm.nih.gov/pubmed/3350331

Sumacetamol is a acetylaminothioalkanoate derivative patented by Sterwin A.-G. as an analgesic and antipyretic agent. Sumacetamol is used in combination with free paracetamol. In clinical trials, Sumacetamol failed to demonstrate superior efficacy in pain and swelling management compare to paracetamol but shows a longer duration of analgesia. The rates of reported adverse events were similar in paracetamol and Sumacetamol, although reports of mild to moderate drowsiness were more common after the Sumacetamol combination.

Originator

Approval Year

PubMed

Title	Date	PubMed
Comparison of a traditional paracetamol medication and a new paracetamol/paracetamol-methionine ester combination.	1984	6468471

Patents

Sample Use Guides

In Vivo Use Guide

b.i.d. (equivalent to 2 g paracetamol X 2)

Route of Administration: Oral

Name

Type

Language

SUMACETAMOL

Official Name

English

SUR-2647

Code

English

SUR 2647

Code

English

sumacetamol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241