OXEPINAC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O4
Molecular Weight	268.2641
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC1=CC2=C(C=C1)C(=O)C3=C(CO2)C=CC=C3

InChI

InChIKey=PYIHCGFQQSKYBO-UHFFFAOYSA-N

InChI=1S/C16H12O4/c17-15(18)8-10-5-6-13-14(7-10)20-9-11-3-1-2-4-12(11)16(13)19/h1-7H,8-9H2,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C16H12O4
Molecular Weight	268.2641
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/350232 | https://www.ncbi.nlm.nih.gov/pubmed/580755

Oxepinac was developed as an anti-inflammatory drug. Results of clinical trials have revealed that oxepinac was an effective and well-tolerated drug in the treatment of painful osteoarthritis. Experiments on animal have shown that oxepinac had no teratogenic effect on fetuses in mice and rabbits. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Teratogenicity study of oxepinac in mice and rabbits.	1978	580755
Acute, subacute and chronic toxicity of oxepinac.	1978	580754
Multi-centered clinical evaluation of oxepinac against peripheral arthropathy particularly osteoarthritis.	1978	350232
Nonsteroidal antiinflammatory agents. 2. Derivatives/analogues of dibenz[b,e]oxepin-3-acetic acid.	1978 Jul	671462
Quantitative analysis of oxepinac in human plasma, urine and saliva by gas chromatography--mass fragmentography.	1980 Apr 11	7380901

Sample Use Guides

In Vivo Use Guide

Male 31, female 104, and the age distribution are 37--82 years and 62 years in average. Three groups of the doses, 75 mg, 150 mg, 300 mg daily, respectively, were administered for two weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:23:08 GMT 2023` Edited by `admin` on `Sat Dec 16 16:23:08 GMT 2023`
Record UNII	PF3750D8AE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXEPINAC

Official Name

English

oxepinac [INN]

Common Name

English

6,11-DIHYDRO-11-OXODIBENZ(B,E)OXEPIN-3-ACETIC ACID

Systematic Name

English

OXEPINAC [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257