U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1 - 10 of 46 results

Status:
US Approved OTC
Source:
21 CFR 355.10(c)(1)(ii) anticaries:dentifrices stannous fluoride
Source URL:
First marketed in 1921
Source:
Calcium Oxide U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Oleylamine (or oleamine) is a versatile and flexible reagent in synthesis as well as the desired surface ligand for the synthesis of nanoparticles. This compound is rather toxic to mammalian organism.
Status:
US Approved OTC
Source:
21 CFR 349.16 ophthalmic:hypertonic agent sodium chloride
Source URL:
First marketed in 1921
Source:
Sodium Chloride U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.
Status:
US Approved OTC
Source:
21 CFR 331.11(i)(2) antacid:calcium-containing calcium (mono or dibasic salt)
Source URL:
First marketed in 1921
Source:
Precipitated Calcium Phosphate N.F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)
Status:
US Approved OTC
Source:
21 CFR 331.11(j)(2) antacid:potassium-containing sodium potassium tartrate
Source URL:
First marketed in 1921
Source:
Potassium Bitartrate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
US Previously Marketed
Source:
Sodium Indigotindisulphonate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Indigotindisulphonate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
Source:
V & M Vitamin and Mineral Supplement by Garden State Nutritionals [Canada]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Magnesium levulinate, the magnesium salt of levulinic acid, is a mineral supplement. It has been shown that in some cases of congenital non-spherocytic haemolytic anaemia (CNSHA) with pyruvate kinase deficiency, the primary defect may be related to diminished magnesium-stimulated ATPase activity, followed by elevation of the erythrocyte ATP level. In CNSHA patients the administration of Magnesium levulinate was followed by an increase in PK activity almost to the control value. This may indicate that magnesium ions stimulate deficient ATPase activity and lead to diminution of ATP as a negative effector for other regulatory enzymes.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

mixture
Status:
US Previously Marketed
First approved in 1961

Class:
MIXTURE

Conditions:

Calcium gluceptate (also known as calcium glucoheptonate) was used, as calcium supplements by people who were unable to get enough calcium or who was needed it more. This drug was used to prevent and to treat several conditions, related to the hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones; it is also needed for the heart, muscles, and nervous system to work properly. Nevertheless, that use of calcium gluceptate was discontinued.