U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Na
Molecular Weight 22.9898
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM

SMILES

[Na]

InChI

InChIKey=MPMYQQHEHYDOCL-UHFFFAOYSA-N
InChI=1S/Na.H

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Effect of increased dietary calcium on the development of reduced renal mass saline hypertension in rats.
1990 Feb
Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics.
1990 Jan
Alterations in dietary sodium affect isoproterenol-induced cardiac hypertrophy.
1990 Oct
Mechanisms of sodium retention in heart failure: relation to the renin-angiotensin-aldosterone system.
1991 Jun
Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patients.
1991 Sep
Inhibition of intestinal sodium-dependent inorganic phosphate transport by fibroblast growth factor 23.
2005 Aug
Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor.
2005 Aug 5
Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1.
2005 Nov
High-yield functional expression of human sodium/d-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence.
2005 Nov 29
Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.
2006 Feb
A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb.
2006 Jan
The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure.
2006 Jan
Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes.
2006 Mar 15
Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells.
2006 Nov 1
Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats.
2006 Oct
Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.
2007 Aug
Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites.
2007 Feb
TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells.
2007 Feb 1
Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.
2007 May
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.
2007 Nov 20
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.
2008 Apr 4
Defective ENaC processing and function in tissue kallikrein-deficient mice.
2008 Feb 22
Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.
2008 Jul
Epithelial sodium channel in a human trophoblast cell line (BeWo).
2008 Jun
Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit.
2008 May
G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.
2008 Sep
Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.
2008 Sep 15
Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.
2009 Apr
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.
2009 Aug 18
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.
2009 Jan
Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.
2009 Jan
Effects of enalapril and sodium depletion on the renin-angiotensin system in hydronephrotic mice.
2009 Jul
Regulation of epithelial sodium channels by cGMP/PKGII.
2009 Jun 1
Interaction of sodium loading and enalapril on renin mRNA and renin release in hydronephrotic mice.
2009 Jun 25
Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.
2009 May
Role of peroxynitrite and recombinant human manganese superoxide dismutase in reducing ischemia-reperfusion renal tissue injury.
2009 Nov
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.
2009 Nov 3
Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.
2009 Sep
Hair tissue mineral analysis and metabolic syndrome.
2009 Sep
Beta2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells.
2010
Long-term terbutaline exposure stimulates alpha1-Na+-K+-ATPase expression at posttranscriptional level in rat fetal distal lung epithelial cells.
2010 Jan
Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.
2010 Oct
Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.
2012 Jun
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.
2012 Jun
Low temperature and chemical rescue affect molecular proximity of DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC).
2012 May 11
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
2013
Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.
2013
Activation of tetrodotoxin-resistant sodium channel NaV1.9 in rat primary sensory neurons contributes to melittin-induced pain behavior.
2013 Mar
Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway.
2014 Apr
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 09:50:15 UTC 2021
Edited
by admin
on Sat Jun 26 09:50:15 UTC 2021
Record UNII
9NEZ333N27
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM
HSDB   MI   VANDF   WHO-DD  
Systematic Name English
NA
Common Name English
SODIUM ATOM
Common Name English
SODIUM [HSDB]
Common Name English
NATRIUM
Systematic Name English
SODIUM [VANDF]
Common Name English
SODIUM, ELEMENTAL
Common Name English
SODIUM METAL
Common Name English
SODIUM [MI]
Common Name English
SODIUM [WHO-DD]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 176.170
Created by admin on Sat Jun 26 09:50:15 UTC 2021 , Edited by admin on Sat Jun 26 09:50:15 UTC 2021
DSLD 145 (Number of products:10421)
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LOINC 57370-9
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WHO-VATC QJ04BA03
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NCI_THESAURUS C1940
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LOINC 60220-1
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FDA ORPHAN DRUG 408413
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WHO-ATC A12CA01
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CFR 21 CFR 101.74
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CFR 21 CFR 862.1665
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Code System Code Type Description
NCI_THESAURUS
C830
Created by admin on Sat Jun 26 09:50:15 UTC 2021 , Edited by admin on Sat Jun 26 09:50:15 UTC 2021
PRIMARY
ECHA (EC/EINECS)
231-132-9
Created by admin on Sat Jun 26 09:50:15 UTC 2021 , Edited by admin on Sat Jun 26 09:50:15 UTC 2021
PRIMARY
PUBCHEM
5360545
Created by admin on Sat Jun 26 09:50:15 UTC 2021 , Edited by admin on Sat Jun 26 09:50:15 UTC 2021
PRIMARY
FDA UNII
9NEZ333N27
Created by admin on Sat Jun 26 09:50:15 UTC 2021 , Edited by admin on Sat Jun 26 09:50:15 UTC 2021
PRIMARY
EPA CompTox
7440-23-5
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PRIMARY
EVMPD
SUB15265MIG
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PRIMARY
MESH
D012964
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PRIMARY
MERCK INDEX
M9978
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PRIMARY Merck Index
CAS
7440-23-5
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PRIMARY
RXCUI
9853
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PRIMARY RxNorm
HSDB
687
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PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 33 mg (2%)