SODIUM

US Previously Marketed

First marketed in 1921

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Na
Molecular Weight	22.9898
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na]

InChI

InChIKey=MPMYQQHEHYDOCL-UHFFFAOYSA-N

InChI=1S/Na.H

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Effect of increased dietary calcium on the development of reduced renal mass saline hypertension in rats.	1990 Feb	2307805
Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics.	1990 Jan	2157753
Alterations in dietary sodium affect isoproterenol-induced cardiac hypertrophy.	1990 Oct	2151337
Mechanisms of sodium retention in heart failure: relation to the renin-angiotensin-aldosterone system.	1991 Jun	1647690
Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patients.	1991 Sep	1930859
Inhibition of intestinal sodium-dependent inorganic phosphate transport by fibroblast growth factor 23.	2005 Aug	16076377
Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor.	2005 Aug 5	16061183
Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1.	2005 Nov	16227998
High-yield functional expression of human sodium/d-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence.	2005 Nov 29	16300400
Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.	2006 Feb	16358215
A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb.	2006 Jan	16344378
The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure.	2006 Jan	16340664
Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes.	2006 Mar 15	16051293
Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells.	2006 Nov 1	16837018
Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats.	2006 Oct	16966582
Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.	2007 Aug	17494632
Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites.	2007 Feb	17242517
TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells.	2007 Feb 1	17188667
Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.	2007 May	17244889
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.	2007 Nov 20	18000046
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.	2007 Sep	17916923
Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.	2008 Apr 4	18230619
Defective ENaC processing and function in tissue kallikrein-deficient mice.	2008 Feb 22	18086683
Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.	2008 Jul	18388193
Epithelial sodium channel in a human trophoblast cell line (BeWo).	2008 Jun	18665318
Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit.	2008 May	18398334
G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.	2008 Sep	18614622
Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.	2008 Sep 15	18538810
Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.	2009 Apr	19139152
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.	2009 Aug 18	19666518
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.	2009 Jan	19139132
Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.	2009 Jan	19026681
Effects of enalapril and sodium depletion on the renin-angiotensin system in hydronephrotic mice.	2009 Jul	19767874
Regulation of epithelial sodium channels by cGMP/PKGII.	2009 Jun 1	19359370
Interaction of sodium loading and enalapril on renin mRNA and renin release in hydronephrotic mice.	2009 Jun 25	19536436
Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.	2009 May	19442819
Role of peroxynitrite and recombinant human manganese superoxide dismutase in reducing ischemia-reperfusion renal tissue injury.	2009 Nov	19917352
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.	2009 Nov 3	19846789
Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.	2009 Sep	19486905
Hair tissue mineral analysis and metabolic syndrome.	2009 Sep	19221698
Beta2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells.	2010	20054151
Long-term terbutaline exposure stimulates alpha1-Na+-K+-ATPase expression at posttranscriptional level in rat fetal distal lung epithelial cells.	2010 Jan	19880505
Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.	2010 Oct	20880397
Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.	2012 Jun	22465659
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.	2012 Jun	22349312
Low temperature and chemical rescue affect molecular proximity of DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC).	2012 May 11	22442149
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.	2013	23516525
Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.	2013	23382806
Activation of tetrodotoxin-resistant sodium channel NaV1.9 in rat primary sensory neurons contributes to melittin-induced pain behavior.	2013 Mar	23264124
Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway.	2014 Apr	24158569

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 09:50:15 UTC 2021` Edited by `admin` on `Sat Jun 26 09:50:15 UTC 2021`
Record UNII	9NEZ333N27
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM

Systematic Name

English

Common Name

English

SODIUM ATOM

Common Name

English

SODIUM [HSDB]

Common Name

English

NATRIUM

Systematic Name

English

SODIUM [VANDF]

Common Name

English

SODIUM, ELEMENTAL

Common Name

English

SODIUM METAL

Common Name

English

SODIUM [MI]

Common Name

English

SODIUM [WHO-DD]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 176.170