SODIUM

US Previously Marketed

First marketed in 1921

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Na
Molecular Weight	22.98976928
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na]

InChI

InChIKey=MPMYQQHEHYDOCL-UHFFFAOYSA-N

InChI=1S/Na.H

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway.	2014-04	24158569
Activation of tetrodotoxin-resistant sodium channel NaV1.9 in rat primary sensory neurons contributes to melittin-induced pain behavior.	2013-03	23264124
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.	2013	23516525
Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.	2013	23382806
Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.	2012-06	22465659
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.	2012-06	22349312
Low temperature and chemical rescue affect molecular proximity of DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC).	2012-05-11	22442149
Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.	2010-10	20880397
Long-term terbutaline exposure stimulates alpha1-Na+-K+-ATPase expression at posttranscriptional level in rat fetal distal lung epithelial cells.	2010-01	19880505
Beta2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells.	2010	20054151
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.	2009-11-03	19846789
Role of peroxynitrite and recombinant human manganese superoxide dismutase in reducing ischemia-reperfusion renal tissue injury.	2009-11	19917352
Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.	2009-09	19486905
Hair tissue mineral analysis and metabolic syndrome.	2009-09	19221698
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.	2009-08-18	19666518
Effects of enalapril and sodium depletion on the renin-angiotensin system in hydronephrotic mice.	2009-07	19767874
Interaction of sodium loading and enalapril on renin mRNA and renin release in hydronephrotic mice.	2009-06-25	19536436
Regulation of epithelial sodium channels by cGMP/PKGII.	2009-06-01	19359370
Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.	2009-05	19442819
Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.	2009-04	19139152
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.	2009-01	19139132
Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.	2009-01	19026681
Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.	2008-09-15	18538810
G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.	2008-09	18614622
Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.	2008-07	18388193
Epithelial sodium channel in a human trophoblast cell line (BeWo).	2008-06	18665318
Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit.	2008-05	18398334
Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.	2008-04-04	18230619
Defective ENaC processing and function in tissue kallikrein-deficient mice.	2008-02-22	18086683
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.	2007-11-20	18000046
Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro.	2007-11	17699549
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.	2007-09	17916923
Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.	2007-08	17494632
Evidence for a decrease in cardiovascular risk factors following recombinant growth hormone administration in abstinent anabolic-androgenic steroid users.	2007-06	17324600
Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet.	2007-05	17308041
Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.	2007-05	17244889
TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells.	2007-02-01	17188667
Recombinant human growth hormone in abstinent androgenic-anabolic steroid use: psychological, endocrine and trophic factor effects.	2007-02	17311540
Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites.	2007-02	17242517
Developmental changes in two voltage-dependent sodium currents in utricular hair cells.	2007-02	17065252
Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells.	2006-11-01	16837018
Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats.	2006-10	16966582
Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice.	2006-10	16847696
Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.	2006-02	16358215
A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb.	2006-01	16344378
Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patients.	1991-09	1930859
Mechanisms of sodium retention in heart failure: relation to the renin-angiotensin-aldosterone system.	1991-06	1647690
Alterations in dietary sodium affect isoproterenol-induced cardiac hypertrophy.	1990-10	2151337
Effect of increased dietary calcium on the development of reduced renal mass saline hypertension in rats.	1990-02	2307805
Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics.	1990-01	2157753

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:12:19 GMT 2025` Edited by `admin` on `Mon Mar 31 18:12:19 GMT 2025`
Record UNII	9NEZ333N27
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Preferred Name

English

SODIUM

Systematic Name

English

SODIUM ATOM

Common Name

English

SODIUM [HSDB]

Common Name

English

NATRIUM

Systematic Name

English

SODIUM [VANDF]

Common Name

English

SODIUM, ELEMENTAL

Common Name

English

SODIUM METAL

Common Name

English

SODIUM [MI]

Common Name

English

Sodium [WHO-DD]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 176.170