U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Investigational
Source:
INN:sulazepam
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Sulazepam is a desmethylbenzodiazepine. It is the thioamide derivative of diazepam. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines. Sulazepam in vivo in experimental animals undergoes enzymic desulfonation, demethylation, and [3C] hydroxylation, with the formation of basic metabolites: diazepam, desmethyldiazepam, and oxazepam.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)



RAC BHFF is the potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA. Exhibits anxiolytic and anticonvulsant activity in vivo and is orally active. RAC BHFF reduces alcohol’s reinforcing properties in alcohol-preferring rats and adds further support to the hypothesis that the positive allosteric modulators of the GABAB receptor may constitute a novel class of agents with therapeutic potential for alcohol dependence.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)



Potassium hydrogen DL-aspartate has being shown to inhibit cell damage and apoptosis induced by ouabain and H2O2. Principal neurotransmitter for fast synaptic excitation. DL-Aspartic acid (DL-Asp) is a racemic mixture of the proteinogenic amino acid L-aspartate and the non-proteinogenic amino acid D-aspartate. DL-Aspartic acid is used in studies on factors and conditions that enhance semen and sperm quality. DL-Aspartic acid is used to develop and assess amino acid racemic resolution and racemic interconversion technologies. Principal neurotransmitter for fast synaptic excitation. It has being shown that DL-Aspartic acid (DL-Asp) administration improves sperm quality in bucks and the high D-Asp content in seminal plasma suggests a primary role for this D-amino acid in regulatory mechanisms of reproductive activity.
7-Nitroindazole (aka 7-NI) is an experimental small molecule that acts as a selective inhibitor of neuronal nitric oxide synthase, which normally converts arginine to citrulline and nitric oxide (NO) in neuronal tissues. It has been investigated for potential use as an anti-nociceptive compound and as a means of mitigating neurodegenerative damage.
Status:
US Previously Marketed
Source:
Paraldehyde U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Paraldehyde U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)


Paraldehyde is the cyclic trimer of acetaldehyde molecules. It was introduced into clinical practice in the UK by the Italian physician Vincenzo Cervello in 1882. It is a central nervous system depressant and was soon found to be an effective anticonvulsant, hypnotic and sedative. It was included in some cough medicines as an expectorant (though there is no known mechanism for this function beyond the placebo effect). Paraldehyde also has been used in the treatment of alcoholism and in the treatment of nervous and mental conditions to calm or relax patients who are nervous or tense and to produce sleep. However, this medicine has generally been replaced by safer and more effective medicines for the treatment of alcoholism and in the treatment of nervous and mental conditions.
Alpha-terpineol is a monoterpene found in the essential oils of several aromatic plant species. It has an anti-inflammatory and antioxidant effects. alpha-Terpineol is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps, and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. alpha-Terpineol was approved by the FDA as a flavor.