.ALPHA.-TERPINEOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H18O
Molecular Weight	154.2493
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CCC(CC1)C(C)(C)O

InChI

InChIKey=WUOACPNHFRMFPN-UHFFFAOYSA-N

InChI=1S/C10H18O/c1-8-4-6-9(7-5-8)10(2,3)11/h4,9,11H,5-7H2,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18640180
Curator's Comment: description was created based on several sources, including: http://www.accessdata.fda.gov/scripts/FCN/fcnDetailNavigation.cfm?rpt=eafuslisting&id=2037 https://www.ncbi.nlm.nih.gov/pubmed/25893282 http://datasheets.scbt.com/sc-291877.pdf

Alpha-terpineol is a monoterpene found in the essential oils of several aromatic plant species. It has an anti-inflammatory and antioxidant effects. alpha-Terpineol is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps, and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. alpha-Terpineol was approved by the FDA as a flavor.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
UDP glucuronosyltransferase family 1 member A4 1 Target ID: 54657.0 Gene Symbol: UGT1A4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8820428	Substrate 661
response to oxygen radical 2 Target ID: GO:0000305 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21540069	Activator 1430
Acetylcholinesterase 207 Target ID: CHEMBL220 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10933142	Inhibitor 8297	5.0 mM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Transient cerebral ischemia 1 Sources: DOI: 10.22038/ijbms.2016.7596	Preventing	Preclinical	Unknown Approved Use Unknown
Painful conditions 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21385090	Primary	Preclinical	Unknown Approved Use Unknown
Convulsions 72 Sources: DOI: 10.1080/13880200601028388	Preventing	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study.	2016 Jul 25	27231091
Multiphase Ozonolysis of Aqueous α-Terpineol.	2016 Nov 1	27680201

Patents

Sample Use Guides

In Vivo Use Guide

α-Terpineol was given at doses of 50, 100, and 200 mg/kg, once daily for 7 days post ischemia.

Route of Administration: Intraperitoneal

In Vitro Use Guide

The rate of glucuronidation of 0.5 mM alpha-terpineol by human embryonic kidney 293 cells expressing UDP-glucuronosyltransferase 1.4 protein is 25 pmol/min/mg protein.

Name

Type

Language

.ALPHA.-TERPINEOL

Common Name

English

3-CYCLOHEXENE-1-METHANOL, ALPHA., .ALPHA., 4-TRIMETHYL-

Common Name

English

ALFA-TERPINEOL

Common Name

English

PC-593

Code

English

FEMA NO. 3045

Code

English

MIL-350

Code

English

.ALPHA.-TERPINEOL [FHFI]

Common Name

English

NSC-403665

Code

English

ALPHA-TERPINEOL [HSDB]

Common Name

English

ALPHA-TERPINEOL [FCC]

Common Name

English

NSC-21449

Code

English

.ALPHA.TERPINEOL

Common Name

English

ALPHA-TERPINEOL

Common Name

English

TERPIN MONOHYDRATE IMPURITY A [EP IMPURITY]

Common Name

English

Alfa-terpineol [WHO-DD]

Common Name

English

.ALPHA.-TERPINEOL [II]

Common Name

English

.ALPHA.-TERPINEOL [MI]

Common Name

English

PINE OIL-593

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

ALPHA-TERPINEOL