POTASSIUM HYDROGEN DL-ASPARTATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C4H5NO4.K.H
Molecular Weight	171.193
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of POTASSIUM HYDROGEN DL-ASPARTATE

Structure Search

SMILES

[H+].[K+].NC(CC([O-])=O)C([O-])=O

InChI

InChIKey=TXXVQZSTAVIHFD-UHFFFAOYSA-M

InChI=1S/C4H7NO4.K/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C4H5NO4
Molecular Weight	131.0868
Charge	-2
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	H
Molecular Weight	1.0079
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25954929 | http://www.sigmaaldrich.com/catalog/product/sigma/a2025?lang=en®ion=RU&cm_sp=Insite-_-recent_fixed-_-recent5-1 | https://www.ncbi.nlm.nih.gov/pubmed/19716665

Potassium hydrogen DL-aspartate has being shown to inhibit cell damage and apoptosis induced by ouabain and H2O2. Principal neurotransmitter for fast synaptic excitation. DL-Aspartic acid (DL-Asp) is a racemic mixture of the proteinogenic amino acid L-aspartate and the non-proteinogenic amino acid D-aspartate. DL-Aspartic acid is used in studies on factors and conditions that enhance semen and sperm quality. DL-Aspartic acid is used to develop and assess amino acid racemic resolution and racemic interconversion technologies. Principal neurotransmitter for fast synaptic excitation. It has being shown that DL-Aspartic acid (DL-Asp) administration improves sperm quality in bucks and the high D-Asp content in seminal plasma suggests a primary role for this D-amino acid in regulatory mechanisms of reproductive activity.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Microsporum gypseum 2 Target ID: CHEMBL612945 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6540570	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Male infertility 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19716665	Primary	Preclinical	Unknown Approved Use Unknown
Cochlear disease 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12764776	Secondary	Preclinical	Unknown Approved Use Unknown
Convulsions 72 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14413228 https://www.ncbi.nlm.nih.gov/pubmed/13843280	Primary	Preclinical	Unknown Approved Use Unknown
Hyperammonemia 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13609089	Primary	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Effect of potassium and magnesium salts of dl-aspartic acid on total plasma CO2 in induced hypercapnea in dogs].	1958	13619185
X-ray absorption near-edge structure (XANES) spectroscopy study of the interaction of silver ions with Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli.	2013 Oct	23934494

Patents

Sample Use Guides

In Vivo Use Guide

Rabbit bucks: The treated group was fed with a concentrate containing DL-Aspartic acid (DL-Asp) which assured a daily administration of 1.3g dl-Asp/head

Route of Administration: Oral

In Vitro Use Guide

The cell survival rates following 48 h incubation in the Potassium hydrogen DL-aspartate (K-asp) (15 mM) and K-asp (25 mM) groups were higher compared with the KCl and MK801 groups. Nissl staining demonstrated that the severity of cell injury in the KCl and K-asp (25 mM) groups were alleviated. In the DAPI staining and transmission electron microscopy analyses, KCl and K-asp (25 mM) reduced the rate of ouabain-induced apoptosis. Flow cytometry revealed that K-asp (25 mM) reduced H2O2 -induced apoptosis. These results demonstrated that K-asp (25 mM) inhibited the ouabain and H2O2-induced SH-SY5Y cell damage and apoptosis, possibly by supplementing levels of intracellular K(+).

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:59:57 GMT 2023` Edited by `admin` on `Sat Dec 16 07:59:57 GMT 2023`
Record UNII	5UW00M8KR0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POTASSIUM HYDROGEN DL-ASPARTATE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID401021780