SULAZEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13ClN2S
Molecular Weight	300.806
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(C=C(Cl)C=C2)C(=NCC1=S)C3=CC=CC=C3

InChI

InChIKey=MWGWTOPCKLQYEU-UHFFFAOYSA-N

InChI=1S/C16H13ClN2S/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11012 | https://link.springer.com/article/10.1007/BF00799472

Sulazepam is a desmethylbenzodiazepine. It is the thioamide derivative of diazepam. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines. Sulazepam in vivo in experimental animals undergoes enzymic desulfonation, demethylation, and [3C] hydroxylation, with the formation of basic metabolites: diazepam, desmethyldiazepam, and oxazepam.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ovarian cancer G-protein coupled receptor 1 1 Target ID: Q15743 Gene ID: 8111.0 Gene Symbol: GPR68 Target Organism: Homo sapiens (Human) Sources: http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2016.193.1_MeetingAbstracts.A1269	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Convulsions 72 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11012	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].	1976 Sep	11012
Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.	2018 Feb	29042451

Patents

Sample Use Guides

In Vivo Use Guide

CBA mice weighing 18-22 g were given an intraperitoneal injection of sulazepam, diazepam, desmethyldiazepam, and oxazepam (5 mg/kg) as an aqueous emulsion with Tween-80.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Sulazepam (50 and 100 uM) both inhibited EGF-induced ASM cell proliferation.

Name

Type

Language

SULAZEPAM

Official Name

English

W-3676

Code

English

sulazepam [INN]

Common Name

English

SULAZEPAM [USAN]

Common Name

English

7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-thione

Systematic Name

English

W 3676

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1012