FLUORIDE ION

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	F
Molecular Weight	18.9984
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-1

SHOW SMILES / InChI

Structure Search

SMILES

[F-]

InChI

InChIKey=KRHYYFGTRYWZRS-UHFFFAOYSA-M

InChI=1S/FH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula	FH
Molecular Weight	20.0063
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24604256http://www.codifa.it/farmaci/e/elmex-gel-dentale-gel-olaflur-e-dectaflur-e-sodio-fluoruro-anticariehttps://www.drugs.com/inactive/calcium-phosphate-dibasic-anhydrous-463.htmlhttp://www.globalrph.com/calcium_supplements.htm | https://www.ncbi.nlm.nih.gov/pubmed/26265479http://apps.who.int/iris/bitstream/10665/43579/1/9789241530729_eng.pdf
Curator's Comment:: description was created based on several sources, including https://www.alfa.com/en/catalog/043674/

Calcium iodide (chemical formula CaI2) is the ionic compound of calcium and iodine, used in cat food as a source of iodine This colourless deliquescent solid is a salt that is highly soluble in water. Calcium iodide properties are similar to those for related salts, such as calcium chloride. Calcium iodide is also used in photography.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Dental caries 105 Sources: https://www.drugs.com/international/olaflur.html https://www.zurrose.at/media/lmiv/08010630.pdf	Preventing	Approved 8043	elmex Approved Use Unknown
Unknown 2502
Hypocalcemia 92 Sources: http://www.globalrph.com/calcium_supplements.htm	Primary	Not Provided 492	Unknown Approved Use Unknown
Chronic obstructive pulmonary disease 191 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26265479	Palliative	Phase I 409	Unknown Approved Use Unknown
Cystic fibrosis 138 Sources: https://clinicaltrials.gov/ct2/show/NCT01543191	Palliative	Phase I 409	Unknown Approved Use Unknown
Unknown 2502
Unknown 2502
Hypocalcemia 92 Sources: https://www.drugs.com/mmx/calcium-phosphate-dibasic.html	Primary	Approved 8043	Unknown Approved Use Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred

PubMed

Title	Date	PubMed
Studies on the calcemic effect of intravenous secretin in humans.	1975 Jun	1220513
Endothelin-induced changes of secondary messengers in cultured corneal endothelial cells.	2001 Aug	11572466
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity.	2001 Aug 28	11513607
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.	2001 Dec 21	11592964
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.	2001 Jul	11435619
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.	2001 Nov	11701772
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.	2001 Nov	11701698
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.	2001 Nov	11606688
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.	2001 Nov 1	11705452
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.	2001 Nov 30	11577072
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.	2001 Oct	11606325
Microarray analysis of differential gene expression in lead-exposed astrocytes.	2001 Oct 1	11578147
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.	2001 Oct 12	11597992
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.	2001 Oct 26	11679415
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.	2001 Sep	11527950
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.	2001 Sep 1	11533133
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.	2001 Sep 15	11535132
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.	2001 Sep 7	11553362
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.	2002 Dec	12456425
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.	2002 Feb	11796525
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.	2002 Jul	12110441
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.	2002 Jul	12101159
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.	2002 Jul 5	11959854
Human kidney diamine oxidase: heterologous expression, purification, and characterization.	2002 Jun	12072962
Expression of functional CCR and CXCR chemokine receptors in podocytes.	2002 Jun 15	12055238
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.	2002 Mar	11895442
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.	2002 Mar	11856964
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	2002 Mar 15	11897840
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.	2002 May 15	11988098
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.	2002 Sep	12181424
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.	2002 Sep 15	12069687
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.	2002 Sep 6	12383957
A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.	2002 Sep 6	12065575
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.	2003 Jan	12388232
Epidemiology of 377 patients with chemical burns in Guangdong province.	2004 Sep	15302423
[Prevention of osteoporosis by foods and dietary supplements. Bioavailability of milk micellar calcium phosphate].	2006 Oct	17012812
Henri Moissan: winner of the Nobel Prize for Chemistry 1906.	2006 Oct 20	16960820
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.	2007 Oct	17507140
Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesity.	2009 Jul-Aug	19567386
A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans.	2012 Apr	22019281
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.	2013 Jan	22083529
Effect of calcium phosphate and vitamin D₃ supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron.	2014 Jan 17	24438153
Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: a systematic review.	2014 Jul	24705069
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.	2014 May 7	24604256
Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model--a clinical trial.	2015 Aug 12	26265479
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.	2015 Jun	25746383
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.	2015 Sep 16	26376110
Lactose behaviour in the presence of lactic acid and calcium.	2016 Aug	27600977
Allergic contact cheilitis caused by olaflur in toothpaste.	2017 Jan	27957754
Effects of ultrasound treatment on physico-chemical, functional properties and antioxidant activity of whey protein isolate in the presence of calcium lactate.	2018 Mar	28802019

Patents

Sample Use Guides

In Vivo Use Guide

toxicity in mice: LD50 = 888 mg/kg

Route of Administration: Intraperitoneal

In Vitro Use Guide

Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.

Substance Class	Chemical Created by `admin` on `Sat Jun 26 09:27:14 UTC 2021` Edited by `admin` on `Sat Jun 26 09:27:14 UTC 2021`
Record UNII	Q80VPU408O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUORIDE ION

Common Name

English

FLUORINE ION(F1-)

Common Name

English

FLUORINE ION

Common Name

English

FLURORIDE-ION

Common Name

English

FLUORIDE ION(1-)

Common Name

English

FLUORIDE

Systematic Name

English

FLUORIDE [VANDF]

Common Name

English

PERFLUORIDE

Common Name

English

Classification Tree Code System Code

WHO-ATC

A12CD51