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Details

Stereochemistry ACHIRAL
Molecular Formula F
Molecular Weight 18.9984032
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of FLUORIDE ION

SMILES

[F-]

InChI

InChIKey=KRHYYFGTRYWZRS-UHFFFAOYSA-M
InChI=1S/FH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula FH
Molecular Weight 20.00634
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004 Aug
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004 Sep
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007 Oct
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013 Jan
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014 May 7
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015 Jun
Allergic contact cheilitis caused by olaflur in toothpaste.
2017 Jan
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:37:25 GMT 2025
Edited
by admin
on Mon Mar 31 18:37:25 GMT 2025
Record UNII
Q80VPU408O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLUORIDE ION
Common Name English
FLUORIDE
VANDF  
Preferred Name English
FLUORINE ION(F1-)
Common Name English
FLUORINE ION
Common Name English
FLURORIDE-ION
Common Name English
FLUORIDE ION(1-)
Common Name English
FLUORIDE [VANDF]
Common Name English
PERFLUORIDE
Common Name English
Classification Tree Code System Code
WHO-ATC A12CD51
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
NCI_THESAURUS C68252
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
DSLD 2968 (Number of products:4)
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
WHO-VATC QA12CD51
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
FDA ORPHAN DRUG 143901
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
Code System Code Type Description
CHEBI
17051
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
PUBCHEM
28179
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
DAILYMED
Q80VPU408O
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
DRUG BANK
DB11257
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
CAS
16984-48-8
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
NCI_THESAURUS
C28149
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
EPA CompTox
DTXSID9049617
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
FDA UNII
Q80VPU408O
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
CHEBI
29228
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
RXCUI
196213
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY RxNorm
EVMPD
SUB21927
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
WIKIPEDIA
FLUORIDE
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
SMS_ID
100000088222
Created by admin on Mon Mar 31 18:37:25 GMT 2025 , Edited by admin on Mon Mar 31 18:37:25 GMT 2025
PRIMARY
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ACTIVE MOIETY