Details
Stereochemistry | ACHIRAL |
Molecular Formula | C4H4NO4S.K |
Molecular Weight | 201.242 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].CC1=CC([O-])=NS(=O)(=O)O1
InChI
InChIKey=WBZFUFAFFUEMEI-UHFFFAOYSA-M
InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1
Molecular Formula | C4H5NO4S |
Molecular Weight | 163.152 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | K |
Molecular Weight | 39.0983 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25019479 |
2.41 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Acesulfame K Approved UseNonnutritive sweetener Launch Date1988 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
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945.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29077645/ |
41 mg single, oral dose: 41 mg route of administration: Oral experiment type: SINGLE co-administered: |
ACESULFAME unknown | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
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36480.85 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29077645/ |
41 mg single, oral dose: 41 mg route of administration: Oral experiment type: SINGLE co-administered: |
ACESULFAME unknown | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
PubMed
Title | Date | PubMed |
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Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics. | 2001 Jul |
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[Simultaneous determination of various food additives by high performance liquid chromatography]. | 2001 Mar |
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Fluoride concentration and pH of iced tea products. | 2002 Nov-Dec |
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Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography. | 2003 Jan-Feb |
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Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice. | 2003 Mar 4 |
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Sweet success: Ionic liquids derived from non-nutritive sweeteners. | 2004 Mar 21 |
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Bitter taste receptors for saccharin and acesulfame K. | 2004 Nov 10 |
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The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. | 2004 Oct 22 |
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[Analysis of nine kinds of sweeteners in foods by LC/MS]. | 2005 Jun |
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Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice. | 2005 Jun 6 |
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Bis(acesulfamato-kappa2N3,O4)bis(2-aminopyrimidine-kappaN1)copper(II). | 2005 May |
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Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days. | 2009 |
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General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. | 2009 Aug |
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Standards of medical care in diabetes--2009. | 2009 Jan |
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In vivo cytogenetic studies on aspartame. | 2010 |
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[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry]. | 2010 Aug |
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[Simultaneous determination of six food additives in meat products by high performance liquid chromatography]. | 2010 Dec |
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Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. | 2010 Jun |
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[Simultaneous determination of various aseptics and sweeteners in milk and dairy products]. | 2010 Mar |
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Rational development of taste masked oral liquids guided by an electronic tongue. | 2010 Nov 15 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17046038
Acesulfame`s effect on the contractile response of isolated rat detrusor muscle strips was evaluated. The atropine-resistant response to EFS was marginally increased by acesulfame K 10(-6) M. Acesulfame K 10(-6) M increased the maximum contractile response to alpha,beta methylene ATP by 35% (+/-9.6%) (p<0.05) and to KCl by 12% (+/-3.1%) (p<0.01). Acesulfame K 10(-6) M increased the log EC(50) from -2.79 (+/-0.037) to -3.03 (+/-0.048, p<0.01).
Substance Class |
Chemical
Created
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admin
on
Edited
Mon Mar 31 17:34:06 GMT 2025
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on
Mon Mar 31 17:34:06 GMT 2025
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Record UNII |
23OV73Q5G9
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C283
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CFR |
21 CFR 172.800
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JECFA EVALUATION |
INS-950
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CODEX ALIMENTARIUS (GSFA) |
INS-950
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DSLD |
1179 (Number of products:14)
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11074431
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DTXSID1030606
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m1308
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CHEMBL176687
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1002505
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760104
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23OV73Q5G9
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55589-62-3
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100000076648
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23OV73Q5G9
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C76512
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259-715-3
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ACESULFAME POTASSIUM
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C006362
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1310545
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SUB11688MIG
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (TLC)
EP
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IMPURITY -> PARENT |
ASSAY (TITRATION)
USP
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Related Record | Type | Details | ||
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ACTIVE MOIETY |