ACESULFAME POTASSIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H4NO4S.K
Molecular Weight	201.242
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].CC1=CC([O-])=NS(=O)(=O)O1

InChI

InChIKey=WBZFUFAFFUEMEI-UHFFFAOYSA-M

InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C4H5NO4S
Molecular Weight	163.152
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0033585 | https://www.sciencedirect.com/science/article/pii/B012227055X01172X | https://www.nhs.uk/Livewell/Goodfood/Pages/the-truth-about-acesulfame-k.aspx | http://www.nytimes.com/1988/07/28/us/new-artificial-sweetener-approved.html

Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carbonic anhydrase IX 36 Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25019479	Inhibitor 8504		2.41 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Obesity 206 Sources: https://www.acesulfamek.org/approval.html https://www.sciencedirect.com/science/article/pii/B9780128030134000016	Preventing		Approved 8583	Acesulfame K Approved Use Nonnutritive sweetener Launch Date 1988

C_max

Value	Dose	Co-administered	Analyte	Population
945.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29077645/	41 mg single, oral dose: 41 mg route of administration: Oral experiment type: SINGLE co-administered:		ACESULFAME unknown	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
36480.85 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29077645/	41 mg single, oral dose: 41 mg route of administration: Oral experiment type: SINGLE co-administered:		ACESULFAME unknown	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

PubMed

Title	Date	PubMed
[Simultaneous determination of six food additives in meat products by high performance liquid chromatography].	2010-12	21438379
Impact of ionic liquids in environment and humans: an overview.	2010-12	20511289
Rational development of taste masked oral liquids guided by an electronic tongue.	2010-11-15	20816732
[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].	2010-08	21261041
Modulation of bitter taste perception by a small molecule hTAS2R antagonist.	2010-06-22	20537538
Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010.	2010-06	20589192
Performance of conventional multi-barrier drinking water treatment plants for the removal of four artificial sweeteners.	2010-06	20462625
An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.	2010-06	20352537
Polymorphism in acesulfame sweetener: structure-property and stability relationships of bending and brittle crystals.	2010-05-28	20422112
Pt(II) and Ag(I) complexes with acesulfame: crystal structure and a study of their antitumoral, antimicrobial and antiviral activities.	2010-05	20149461
[Simultaneous determination of various aseptics and sweeteners in milk and dairy products].	2010-03	20549988
Inadequate toxicity tests of food additive acesulfame.	2010-02-20	20166324
Standards of medical care in diabetes--2010.	2010-01	20042772
In vivo cytogenetic studies on aspartame.	2010	20689731
General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.	2009-08	19634935
Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial.	2009-07-22	19624856
Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).	2009-07	19533103
Ubiquitous occurrence of the artificial sweetener acesulfame in the aquatic environment: an ideal chemical marker of domestic wastewater in groundwater.	2009-06-15	19603650
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.	2009-03	19106249
[Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography].	2009-01	19449553
Standards of medical care in diabetes--2009.	2009-01	19118286
Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days.	2009	22573997
Glucose sensing in L cells: a primary cell study.	2008-12	19041768
Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss.	2008-10-26	18950537
Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment.	2008-09	18639604
Detection of food additives by voltammetry at the liquid-liquid interface.	2008-06-25	18512937
The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.	2007-10-12	17935609
Behavioral genetics and taste.	2007-09-18	17903279
Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2.	2007-07-01	17495045
The erosive potential of some flavoured waters.	2007-01	19212489
Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx.	2006-12-01	17046038
Testing needed for acesulfame potassium, an artificial sweetener.	2006-09	16966071
Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis.	2006-05	16830728
Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664].	2006-03-24	16556326
Development of a healthy biscuit: an alternative approach to biscuit manufacture.	2006-03-15	16539719
Taste masking analysis in pharmaceutical formulation development using an electronic tongue.	2006-03-09	16431048
NTP toxicology studies of acesulfame potassium (CAS No. 55589-62-3) in genetically modified (FVB Tg.AC Hemizygous) mice and carcinogenicity studies of acesulfame potassium in genetically modified [B6.129-Trp53(tm1Brd) (N5) Haploinsufficient] mice (feed studies)mice.	2005-10	18784762
Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	2005-06-06	15938754
[Analysis of nine kinds of sweeteners in foods by LC/MS].	2005-06	16042292
Bis(acesulfamato-kappa2N3,O4)bis(2-aminopyrimidine-kappaN1)copper(II).	2005-05	15876705
Bitter taste receptors for saccharin and acesulfame K.	2004-11-10	15537898
The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.	2004-10-22	15299024
Dietary estimated intake of intense sweeteners by Italian teenagers. Present levels and projections derived from the INRAN-RM-2001 food survey.	2004-04	15019193
Sweet success: Ionic liquids derived from non-nutritive sweeteners.	2004-03-21	15010753
The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets.	2003-05-12	12711177
Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice.	2003-03-04	12617752
Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography.	2003-02-28	12607744
Fluoride concentration and pH of iced tea products.	2002-12-03	12459612
Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics.	2001-07	11397521
[Simultaneous determination of various food additives by high performance liquid chromatography].	2001-03	12541649

Patents

Sample Use Guides

In Vivo Use Guide

Acceptable daily intake: 9mg per kg of body weight

Route of Administration: Oral

In Vitro Use Guide

Acesulfame`s effect on the contractile response of isolated rat detrusor muscle strips was evaluated. The atropine-resistant response to EFS was marginally increased by acesulfame K 10(-6) M. Acesulfame K 10(-6) M increased the maximum contractile response to alpha,beta methylene ATP by 35% (+/-9.6%) (p<0.05) and to KCl by 12% (+/-3.1%) (p<0.01). Acesulfame K 10(-6) M increased the log EC(50) from -2.79 (+/-0.037) to -3.03 (+/-0.048, p<0.01).

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:06 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:06 GMT 2025`
Record UNII	23OV73Q5G9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACESULFAME POTASSIUM

Common Name

English

POTASSIUM ACESULFAME

Preferred Name

English

POTASSIUM ACESULFAMATE

Common Name

English

1,2,3-OXATHIAZIN-4(3H)-ONE, 6-METHYL-, 2,2-DIOXIDE, POTASSIUM SALT (1:1)

Systematic Name

English

ACESULFAME POTASSIUM SALT [MI]

Common Name

English

ACESULFAME POTASSIUM [FCC]

Common Name

English

3,4-Dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide potassium salt

Common Name

English

6-METHYL-1,2,3-OXATHIAZINE-4(3H)-ONE-2,2-DIOXIDE POTASSIUM SALT

Common Name

English

E-950

Code

English

ACESULFAME POTASSIUM [USP-RS]

Common Name

English

ACESULFAME POTASSIUM [II]

Common Name

English

E 950

Code

English

SUNETT D

Common Name

English

Acesulfame potassium [WHO-DD]

Common Name

English

OTIZON

Common Name

English

ACESULFAME POTASSIUM [EP MONOGRAPH]

Common Name

English

ACESULFAME POTASSIUM [MART.]

Common Name

English

NSC-760104

Code

English

INS-950

Code

English

ACESULFAME K

Common Name

English

ACESULFAME POTASSIUM SALT

Common Name

English

INS NO.950

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C283