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Details

Stereochemistry ACHIRAL
Molecular Formula C4H4NO4S.K
Molecular Weight 201.242
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACESULFAME POTASSIUM

SMILES

[K+].CC1=CC([O-])=NS(=O)(=O)O1

InChI

InChIKey=WBZFUFAFFUEMEI-UHFFFAOYSA-M
InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C4H5NO4S
Molecular Weight 163.152
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.

Originator

Curator's Comment: Acesulfame potassium was developed after the accidental discovery of a similar compound (5,6-dimethyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide) in 1967 by Karl Clauss and Harald Jensen at Hoechst AG.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
2.41 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Acesulfame K

Approved Use

Nonnutritive sweetener

Launch Date

1988
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
945.3 ng/mL
41 mg single, oral
dose: 41 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ACESULFAME unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
36480.85 ng × h/mL
41 mg single, oral
dose: 41 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ACESULFAME unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
PubMed

PubMed

TitleDatePubMed
Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics.
2001 Jul
[Simultaneous determination of various food additives by high performance liquid chromatography].
2001 Mar
Fluoride concentration and pH of iced tea products.
2002 Nov-Dec
Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography.
2003 Jan-Feb
Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice.
2003 Mar 4
Sweet success: Ionic liquids derived from non-nutritive sweeteners.
2004 Mar 21
Bitter taste receptors for saccharin and acesulfame K.
2004 Nov 10
The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.
2004 Oct 22
[Analysis of nine kinds of sweeteners in foods by LC/MS].
2005 Jun
Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.
2005 Jun 6
Bis(acesulfamato-kappa2N3,O4)bis(2-aminopyrimidine-kappaN1)copper(II).
2005 May
Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days.
2009
General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.
2009 Aug
Standards of medical care in diabetes--2009.
2009 Jan
In vivo cytogenetic studies on aspartame.
2010
[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].
2010 Aug
[Simultaneous determination of six food additives in meat products by high performance liquid chromatography].
2010 Dec
Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010.
2010 Jun
[Simultaneous determination of various aseptics and sweeteners in milk and dairy products].
2010 Mar
Rational development of taste masked oral liquids guided by an electronic tongue.
2010 Nov 15
Patents

Patents

Sample Use Guides

Acceptable daily intake: 9mg per kg of body weight
Route of Administration: Oral
Acesulfame`s effect on the contractile response of isolated rat detrusor muscle strips was evaluated. The atropine-resistant response to EFS was marginally increased by acesulfame K 10(-6) M. Acesulfame K 10(-6) M increased the maximum contractile response to alpha,beta methylene ATP by 35% (+/-9.6%) (p<0.05) and to KCl by 12% (+/-3.1%) (p<0.01). Acesulfame K 10(-6) M increased the log EC(50) from -2.79 (+/-0.037) to -3.03 (+/-0.048, p<0.01).
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:34:06 GMT 2025
Edited
by admin
on Mon Mar 31 17:34:06 GMT 2025
Record UNII
23OV73Q5G9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACESULFAME POTASSIUM
EP   FCC   II   MART.   USP-RS   WHO-DD  
Common Name English
POTASSIUM ACESULFAME
INCI  
INCI  
Preferred Name English
POTASSIUM ACESULFAMATE
Common Name English
1,2,3-OXATHIAZIN-4(3H)-ONE, 6-METHYL-, 2,2-DIOXIDE, POTASSIUM SALT (1:1)
Systematic Name English
ACESULFAME POTASSIUM SALT [MI]
Common Name English
ACESULFAME POTASSIUM [FCC]
Common Name English
3,4-Dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide potassium salt
Common Name English
6-METHYL-1,2,3-OXATHIAZINE-4(3H)-ONE-2,2-DIOXIDE POTASSIUM SALT
Common Name English
E-950
Code English
ACESULFAME POTASSIUM [USP-RS]
Common Name English
ACESULFAME POTASSIUM [II]
Common Name English
E 950
Code English
SUNETT D
Common Name English
Acesulfame potassium [WHO-DD]
Common Name English
OTIZON
Common Name English
ACESULFAME POTASSIUM [EP MONOGRAPH]
Common Name English
ACESULFAME POTASSIUM [MART.]
Common Name English
NSC-760104
Code English
INS-950
Code English
ACESULFAME K
Common Name English
ACESULFAME POTASSIUM SALT
MI  
Common Name English
INS NO.950
Code English
Classification Tree Code System Code
NCI_THESAURUS C283
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
CFR 21 CFR 172.800
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
JECFA EVALUATION INS-950
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
CODEX ALIMENTARIUS (GSFA) INS-950
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
DSLD 1179 (Number of products:14)
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
Code System Code Type Description
PUBCHEM
11074431
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
EPA CompTox
DTXSID1030606
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
MERCK INDEX
m1308
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY Merck Index
ChEMBL
CHEMBL176687
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
RS_ITEM_NUM
1002505
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
NSC
760104
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
DAILYMED
23OV73Q5G9
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
CAS
55589-62-3
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
SMS_ID
100000076648
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
FDA UNII
23OV73Q5G9
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
NCI_THESAURUS
C76512
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
ECHA (EC/EINECS)
259-715-3
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
WIKIPEDIA
ACESULFAME POTASSIUM
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
MESH
C006362
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
RXCUI
1310545
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY RxNorm
EVMPD
SUB11688MIG
Created by admin on Mon Mar 31 17:34:06 GMT 2025 , Edited by admin on Mon Mar 31 17:34:06 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (TLC)
EP
IMPURITY -> PARENT
ASSAY (TITRATION)
USP
Related Record Type Details
ACTIVE MOIETY