Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H5NO4S |
| Molecular Weight | 163.152 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC(=O)NS(=O)(=O)O1
InChI
InChIKey=YGCFIWIQZPHFLU-UHFFFAOYSA-N
InChI=1S/C4H5NO4S/c1-3-2-4(6)5-10(7,8)9-3/h2H,1H3,(H,5,6)
| Molecular Formula | C4H5NO4S |
| Molecular Weight | 163.152 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25019479 |
2.41 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Acesulfame K Approved UseNonnutritive sweetener Launch Date1988 |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
945.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29077645/ |
41 mg single, oral dose: 41 mg route of administration: Oral experiment type: SINGLE co-administered: |
ACESULFAME unknown | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
36480.85 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29077645/ |
41 mg single, oral dose: 41 mg route of administration: Oral experiment type: SINGLE co-administered: |
ACESULFAME unknown | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Simultaneous determination of six food additives in meat products by high performance liquid chromatography]. | 2010-12 |
|
| Impact of ionic liquids in environment and humans: an overview. | 2010-12 |
|
| Rational development of taste masked oral liquids guided by an electronic tongue. | 2010-11-15 |
|
| [Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry]. | 2010-08 |
|
| Modulation of bitter taste perception by a small molecule hTAS2R antagonist. | 2010-06-22 |
|
| Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. | 2010-06 |
|
| Performance of conventional multi-barrier drinking water treatment plants for the removal of four artificial sweeteners. | 2010-06 |
|
| An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine. | 2010-06 |
|
| Polymorphism in acesulfame sweetener: structure-property and stability relationships of bending and brittle crystals. | 2010-05-28 |
|
| Pt(II) and Ag(I) complexes with acesulfame: crystal structure and a study of their antitumoral, antimicrobial and antiviral activities. | 2010-05 |
|
| [Simultaneous determination of various aseptics and sweeteners in milk and dairy products]. | 2010-03 |
|
| Inadequate toxicity tests of food additive acesulfame. | 2010-02-20 |
|
| Standards of medical care in diabetes--2010. | 2010-01 |
|
| In vivo cytogenetic studies on aspartame. | 2010 |
|
| General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. | 2009-08 |
|
| Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial. | 2009-07-22 |
|
| Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). | 2009-07 |
|
| Ubiquitous occurrence of the artificial sweetener acesulfame in the aquatic environment: an ideal chemical marker of domestic wastewater in groundwater. | 2009-06-15 |
|
| Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. | 2009-03 |
|
| [Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography]. | 2009-01 |
|
| Standards of medical care in diabetes--2009. | 2009-01 |
|
| Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days. | 2009 |
|
| Glucose sensing in L cells: a primary cell study. | 2008-12 |
|
| Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss. | 2008-10-26 |
|
| Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment. | 2008-09 |
|
| Detection of food additives by voltammetry at the liquid-liquid interface. | 2008-06-25 |
|
| The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. | 2007-10-12 |
|
| Behavioral genetics and taste. | 2007-09-18 |
|
| Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. | 2007-07-01 |
|
| The erosive potential of some flavoured waters. | 2007-01 |
|
| Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx. | 2006-12-01 |
|
| Testing needed for acesulfame potassium, an artificial sweetener. | 2006-09 |
|
| Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis. | 2006-05 |
|
| Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. | 2006-03-24 |
|
| Development of a healthy biscuit: an alternative approach to biscuit manufacture. | 2006-03-15 |
|
| Taste masking analysis in pharmaceutical formulation development using an electronic tongue. | 2006-03-09 |
|
| NTP toxicology studies of acesulfame potassium (CAS No. 55589-62-3) in genetically modified (FVB Tg.AC Hemizygous) mice and carcinogenicity studies of acesulfame potassium in genetically modified [B6.129-Trp53(tm1Brd) (N5) Haploinsufficient] mice (feed studies)mice. | 2005-10 |
|
| Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice. | 2005-06-06 |
|
| [Analysis of nine kinds of sweeteners in foods by LC/MS]. | 2005-06 |
|
| Bis(acesulfamato-kappa2N3,O4)bis(2-aminopyrimidine-kappaN1)copper(II). | 2005-05 |
|
| Bitter taste receptors for saccharin and acesulfame K. | 2004-11-10 |
|
| The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. | 2004-10-22 |
|
| Dietary estimated intake of intense sweeteners by Italian teenagers. Present levels and projections derived from the INRAN-RM-2001 food survey. | 2004-04 |
|
| Sweet success: Ionic liquids derived from non-nutritive sweeteners. | 2004-03-21 |
|
| The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets. | 2003-05-12 |
|
| Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice. | 2003-03-04 |
|
| Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography. | 2003-02-28 |
|
| Fluoride concentration and pH of iced tea products. | 2002-12-03 |
|
| Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics. | 2001-07 |
|
| [Simultaneous determination of various food additives by high performance liquid chromatography]. | 2001-03 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17046038
Acesulfame`s effect on the contractile response of isolated rat detrusor muscle strips was evaluated. The atropine-resistant response to EFS was marginally increased by acesulfame K 10(-6) M. Acesulfame K 10(-6) M increased the maximum contractile response to alpha,beta methylene ATP by 35% (+/-9.6%) (p<0.05) and to KCl by 12% (+/-3.1%) (p<0.01). Acesulfame K 10(-6) M increased the log EC(50) from -2.79 (+/-0.037) to -3.03 (+/-0.048, p<0.01).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:21:47 GMT 2025
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Mon Mar 31 18:21:47 GMT 2025
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| Record UNII |
MA3UYZ6K1H
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C283
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SUB05216MIG
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3914
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36573
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251-622-6
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DTXSID0048006
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1310546
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CHEMBL176687
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Acesulfame
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MA3UYZ6K1H
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MA3UYZ6K1H
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3768
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C76511
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m1308
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100000087935
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ACTIVE MOIETY |