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Development Status

US Approved OTC

25

Possibly Marketed Outside US

5

Other

1

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Primary Target

Acyl coenzyme A:cholesterol acyltransferase 1

2

Anandamide amidohydrolase

2

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Highest Phase

Approved

25

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Approval Year

1921

25

2012

3

2024

2

Unknown

1

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Condition

Dental caries

25

Unknown

25

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Treatment Modality

Preventing

25

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CNS Activity

CNS Non-penetrant

25

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Originator

Marthaler, T.M.

25

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Substance Class

Chemical

31

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INN Stem

Chemical substance(-ine)

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Code System

CAS

31

FDA UNII

31

PUBCHEM

31

EPA CompTox

29

ECHA (EC/EINECS)

23

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

5

BLOOD AND BLOOD FORMING ORGANS

1

GENITO URINARY SYSTEM AND SEX HORMONES

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ATC Level 2

MINERAL SUPPLEMENTS

3

STOMATOLOGICAL PREPARATIONS

3

BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

1

UROLOGICALS

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ATC Level 3

STOMATOLOGICAL PREPARATIONS

3

OTHER MINERAL SUPPLEMENTS

2

CALCIUM

1

I.V. SOLUTION ADDITIVES

1

OTHER UROLOGICALS, INCL. ANTISPASMODICS

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ATC Level 4

Caries prophylactic agents

3

Fluoride

2

Acidifiers

1

Calcium

1

Electrolyte solutions

1

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Substance Form

Salts, Hydrates, Esters, etc.

27

Principal Form

4

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Showing 1 - 10 of 31 results

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FLUORIDE ION

Q80VPU408O

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

N,N'-METHYLENEBIS(STEARAMIDE)

368D64UN1M

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

ELAIDAMIDE

GOU8K597IT

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Status:

Possibly Marketed Outside US

First approved in 2024

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acyl coenzyme A:cholesterol acyltransferase 1

Anandamide amidohydrolase

STEARAMINE

FFV58UNY7O

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Status:

Possibly Marketed Outside US

First approved in 2012

Class (Stereo):

CHEMICAL (ACHIRAL)

Stearamine is an aliphatic amine intended for use in cosmetic formulations as antistatic agent. In cosmetics and personal care products, Lauramine and Stearamine have been used in hair preparations. Stearamine is also used as a corrosion-inhibiting b...

oiler-water additive. Stearamine has antimicrobial properties. Stearylamine has been shown to prevent drug (lansoprazole) degradation and maintained drug stable in nanostructured lipid carriers (NLCs). Stearamine is used as positive charge inducing agent in different pharmaceutical formulations. Thus, the presence of stearylamine reduced the permeability coefficient for the cationic species of the drugs by approximately an order of magnitude, but had no effect on the neutral species of the drugs. The efflux curves observed for both verapamil and prochlorperazine could be mathematically modeled by assuming that the primary influence of stearylamine was on the development of a positive surface charge density on the inner monolayer of the liposome. Taken in sum, these results indicate that stearylamine is effective at decreasing the leakage of cationic drugs from liposomes, and may prove to be a valuable component of liposomal drug formulations.

Sodium fluoride

8ZYQ1474W7

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

TIN DIOXIDE HYDRATE

RPZ95PH4UX

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

STANNIC CATION

XPM618Y22P

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CALCIUM PHOSPHIDE

IQZ9FY9THC

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

STANNIC SULFIDE

YVY89V9BUH

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CALCIUM HYDRIDE

WY779SQ0XW

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Status:

US Approved OTC

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gel...

s for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

Showing 1 - 10 of 31 results

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