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Details

Stereochemistry ACHIRAL
Molecular Formula Sn
Molecular Weight 118.71
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 4

SHOW SMILES / InChI
Structure of STANNIC CATION

SMILES

[Sn+4]

InChI

InChIKey=SYRHIZPPCHMRIT-UHFFFAOYSA-N
InChI=1S/Sn/q+4

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Allergic contact cheilitis caused by olaflur in toothpaste.
2017-01
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015-06
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014-05-07
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007-10
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004-09
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004-08
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Name Type Language
STANNIC CATION
Common Name English
SN4+
Preferred Name English
TIN(4+) ION
Common Name English
STANNIC ION
Common Name English
TIN(IV) ION
Common Name English
TIN ION(4+)
Common Name English
Code System Code Type Description
PUBCHEM
4077523
Created by admin on Tue Apr 01 17:06:20 GMT 2025 , Edited by admin on Tue Apr 01 17:06:20 GMT 2025
PRIMARY
CHEBI
30476
Created by admin on Tue Apr 01 17:06:20 GMT 2025 , Edited by admin on Tue Apr 01 17:06:20 GMT 2025
PRIMARY
FDA UNII
XPM618Y22P
Created by admin on Tue Apr 01 17:06:20 GMT 2025 , Edited by admin on Tue Apr 01 17:06:20 GMT 2025
PRIMARY
DAILYMED
XPM618Y22P
Created by admin on Tue Apr 01 17:06:20 GMT 2025 , Edited by admin on Tue Apr 01 17:06:20 GMT 2025
PRIMARY
CAS
22537-50-4
Created by admin on Tue Apr 01 17:06:20 GMT 2025 , Edited by admin on Tue Apr 01 17:06:20 GMT 2025
PRIMARY