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Details

Stereochemistry ACHIRAL
Molecular Formula F.Na
Molecular Weight 41.9881725
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Sodium fluoride

SMILES

[F-].[Na+]

InChI

InChIKey=PUZPDOWCWNUUKD-UHFFFAOYSA-M
InChI=1S/FH.Na/h1H;/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula FH
Molecular Weight 20.00634
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Allergic contact cheilitis caused by olaflur in toothpaste.
2017-01
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015-06
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014-05-07
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007-10
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004-09
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004-08
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Wed Apr 02 18:27:34 GMT 2025
Edited
by admin
on Wed Apr 02 18:27:34 GMT 2025
Record UNII
8ZYQ1474W7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NATRUM FLUORATUM
HPUS  
Preferred Name English
Sodium fluoride
DASH   EP   HSDB   INCI   ISO   JAN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
NSC-77385
Code English
DENTALFLUORO
Common Name English
COLGATE TOTAL COMPONENT SODIUM FLUORIDE
Common Name English
SODIUM FLUORIDE [ISO]
Common Name English
FLUORIDE (AS SODIUM) [VANDF]
Common Name English
NATRII FLUORIDUM [WHO-IP LATIN]
Common Name English
SODIUM FLUORIDE [ORANGE BOOK]
Common Name English
SODIUM FLUORIDE [VANDF]
Common Name English
SODIUM FLUORIDE [USP MONOGRAPH]
Common Name English
SODIUM FLUORIDE [MI]
Common Name English
SODIUM FLUORIDE [JAN]
Common Name English
SODIUM FLUORIDE [HSDB]
Common Name English
SODIUM FLUORIDE [EP MONOGRAPH]
Common Name English
SODIUM FLUORIDE (NAF)
Common Name English
SODIUM FLUORIDE [WHO-IP]
Common Name English
Sodium fluoride [WHO-DD]
Common Name English
PERGANTENE
Common Name English
NATRUM FLUORATUM [HPUS]
Common Name English
FLUORIDE (AS SODIUM FLUORIDE) [VANDF]
Common Name English
SODIUM FLUORIDE [USP-RS]
Common Name English
NEUTRAL SODIUM FLUORIDE
Brand Name English
SODIUM FLUORIDE [MART.]
Common Name English
Classification Tree Code System Code
WHO-ATC A01AA51
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
WHO-ESSENTIAL MEDICINES LIST 27
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
CFR 21 CFR 355.70
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
WHO-VATC QA01AA01
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
EPA PESTICIDE CODE 75202
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
WHO-ATC A12CD01
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
WHO-VATC QA12CD01
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
CFR 21 CFR 355.60
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
CFR 21 CFR 355.20
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
WHO-ATC A01AA01
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
CFR 21 CFR 355.10
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
CFR 21 CFR 355.50
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
CFR 21 CFR 355.55
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
NCI_THESAURUS C802
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL1528
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
MERCK INDEX
m10024
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY Merck Index
WIKIPEDIA
Fluoride therapy
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
RS_ITEM_NUM
1614002
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
NCI_THESAURUS
C832
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
CHEBI
28741
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
CAS
7681-49-4
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
MESH
D012969
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
WIKIPEDIA
SODIUM FLUORIDE
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
EVMPD
SUB15285MIG
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
FDA UNII
8ZYQ1474W7
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
SMS_ID
100000091554
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
HSDB
1766
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
EPA CompTox
DTXSID2020630
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
DRUG CENTRAL
4243
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
PUBCHEM
5235
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
DAILYMED
8ZYQ1474W7
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
ALANWOOD
sodium fluoride
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
ECHA (EC/EINECS)
231-667-8
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
RXCUI
9873
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY RxNorm
DRUG BANK
DB09325
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
NSC
77385
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
SODIUM FLUORIDE
Created by admin on Wed Apr 02 18:27:34 GMT 2025 , Edited by admin on Wed Apr 02 18:27:34 GMT 2025
PRIMARY Description: A white powder; odourless. Solubility: Soluble in water; practically insoluble in ethanol (~750 g/l) TS. Category: Mineral salt. Storage: Sodium fluoride should be kept in a well-closed container. Definition: Sodium fluoride contains not less than 98.0% and not more than 101.0% of NaF, calculated with reference to the dried substance.
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY