U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula FH
Molecular Weight 20.0063
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROFLUORIC ACID

SMILES

F

InChI

InChIKey=KRHYYFGTRYWZRS-UHFFFAOYSA-N
InChI=1S/FH/h1H

HIDE SMILES / InChI

Molecular Formula FH
Molecular Weight 20.0063
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004 Aug
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007 Oct
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013 Jan
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014 May 7
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015 Jun
Allergic contact cheilitis caused by olaflur in toothpaste.
2017 Jan
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:59:49 UTC 2023
Edited
by admin
on Thu Jul 06 00:59:49 UTC 2023
Record UNII
RGL5YE86CZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROFLUORIC ACID
HSDB   MART.   MI   VANDF   WHO-DD  
Systematic Name English
HYDROFLUORIC ACID [HSDB]
Common Name English
HYDROGEN FLUORIDE
MI  
Systematic Name English
HYDROFLUORICUM ACIDUM
HPUS  
Common Name English
NSC-750679
Code English
HYDROFLUORIC ACID [MART.]
Common Name English
HYDROFLUORICUM ACIDUM [HPUS]
Common Name English
HYDROFLUORIC ACID [MI]
Common Name English
Hydrofluoric acid [WHO-DD]
Common Name English
HYDROFLUORIC ACID [VANDF]
Common Name English
HYDROGEN FLUORIDE [MI]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 45601
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
Code System Code Type Description
FDA UNII
RGL5YE86CZ
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-634-8
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
MERCK INDEX
M6103
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY Merck Index
CAS
7664-39-3
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
NSC
750679
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
DRUG CENTRAL
4499
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
DRUG BANK
DB11072
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
CONCEPT Industrial Aid
EPA CompTox
DTXSID1049641
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
MESH
D006858
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
PUBCHEM
14917
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
WIKIPEDIA
HYDROFLUORIC ACID
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
SMS_ID
100000077598
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
CHEBI
29228
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
RXCUI
5496
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY RxNorm
EVMPD
SUB14134MIG
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
MERCK INDEX
M6097
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY Merck Index
HSDB
546
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
NCI_THESAURUS
C82286
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
DAILYMED
RGL5YE86CZ
Created by admin on Thu Jul 06 00:59:50 UTC 2023 , Edited by admin on Thu Jul 06 00:59:50 UTC 2023
PRIMARY
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