U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 61 - 70 of 430 results

Status:
Possibly Marketed Outside US
Source:
NCT00329680: Phase 4 Interventional Completed Sepsis
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Gamolenic acid also known as gamma-linolenic acid is a natural component of Oenothera biennis L. (Evening Primrose). Gamolenic acid was used for the treatment of breast painand atopic dermatitis in Europe, although now the drug is withdrawn from the market (there is no safety issue associated with the withdrawal of the licences). The mechanism of action of gamolenic acid is connected with its interaction with prostanoid pathway.
Diethyltoluamide (DEET) is an insect repellent used to keep insects away. This product is effective against mosquitoes, biting flies (gnats, sandflies, deer flies, stable flies, black flies), ticks, harvest mites, and fleas. DEET is absorbed through the skin. DEET has few adverse effects when applied as directed. The most common problem is local skin irritation, including erythema and pruritis, at the site of application.
Status:
Possibly Marketed Outside US
Source:
Perfluorodecalin Dk-Line by McBee, E.T.|Bechtol, L.D.
Source URL:

Class (Stereo):
CHEMICAL (MIXED)


Perflunafene is a perfluorocarbon that can absorb, transport, and release oxygen and carbon dioxide. Perflunafene is a can be used as an alternative to red blood cell preparations to improve gaseous transport, in particular oxygen supply, to the tissues. Intra-ocular injection of perflunafene is used to provide temporary tamponade in ophthalmic procedures such as retinal re-attachment. Perflunafene and perfluamine have been used together for their oxygen-carrying properties in blood substitute preparations and to prevent myocardial ischaemia during percutaneous transluminal coronary angioplasty.
Zeaxanthin is one of the most common carotenoid alcohols found in nature. It is synthesized in plants and some micro-organisms. Lutein and Zeaxanthin are found in the macula of the human retina, as well as the human crystalline lens. They play a role in protection against age-related macular degeneration (ARMD) and cataract formation. The antioxidant properties of lutein and zeaxanthin together with ocular antioxidants (selenium, zinc, copper, vitamin A, C, E, etc.) inhibit free radical damage caused by light and oxygen. Zeaxanthin supplements are typically taken on the supposition of supporting eye health. It is is Generally Recognized As Safe by FDA.
Status:
Possibly Marketed Outside US
Source:
Canada:SODIUM DICHLOROISOCYANURATE
Source URL:
First approved in 2013

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.
Status:
Possibly Marketed Outside US
Source:
ECTOMETHRIN by National Research Development Corporation
Source URL:

Class (Stereo):
CHEMICAL (MIXED)



Cypermethrin is a synthetic, pyrethroid insecticide that has high insecticidal activity, low avian and mammalian toxicity. Cypermethrin works by quickly affecting the insect’s central nervous system. The major target site of cypermethrin is the sodium channel of the nerve membrane. A sodium channel exposed to cypermethrin can remain open much longer, even up to several seconds. It is used to control many pests including lepidopterous pests of cotton, fruit, and vegetable crops. In veterinary, it is applied topically for the control of ectoparasites such as ticks, fleas, lice and blowflies.
Status:
Possibly Marketed Outside US
Source:
NCT02469337: Phase 4 Interventional Unknown status Insulin Resistance
(2012)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Dichloroacetic acid, often abbreviated DCA (dichloroacetate), is an acid analog of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness. DCA was approved for use in Canada in 1989 (as a topical formulation for the treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market. DCA is a noncompetitive inhibitor of the endoplasmic reticulum enzyme HMG CoA reductase, which catalyzes the rate limiting step in cholesterol biosynthesis. DCA has been researched in adults, children, animals, and cells as a monotherapy as well as in combination with other therapies for the treatment of severe metabolic disorders including diabetes and hypercholesterolemia, lactic acidosis, certain heart conditions, and cancer. DCA has been prescribed to reduce tumour size and tumour markers, prevent angiogenesis, reduce cancer related symptoms, manage pain, and aid in palliation.
Status:
Possibly Marketed Outside US
Source:
Mary Kay Timewise Repair Volu-Firm The Go Set
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Tiamulin is a diterpene antimicrobial with a pleuromutilin chemical structure similar to that of valnemulin. The activity of tiamulin is largely confined to gram-positive micro-organisms and mycoplasma. Tiamulin acts by inhibiting protein synthesis at the ribosomal level. In veterinary medicine, tiamulin is used for treatment and prophylaxis of dysentery, pneumonia and mycoplasmal infections in pigs and poultry. Tiamulin is available as a 2, 10 or 20% premix for pigs and poultry, a 12.5% solution or 45% water soluble powder for addition to drinking water for pigs and poultry, or a 10% injectable formulation for pigs. Tiamulin inhibits protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.
Oxfendazole is a broad spectrum benzimidazole anthelmintic. Oxfendazole has broad-spectrum activity against inhibited larval stages of gastrointestinal roundworms, tapeworms, and lungworms in many animal species at doses between 4.5–10 mg/kg.