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AFIMOXIFENE, E-ISOMER

AKE3PH0IML

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Estrogen-related receptor gamma

Estrogen receptor

Conditions:

Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen exerting estrogen receptor modulatory function. In addition, hydroxytamoxifen binds to regulates transcriptional activity of the estrogen-related receptor gamma. ASCEND Therapeutics,...

Inc. was developing TamoGel (4-hydroxytamoxifen gel) for a variety of estrogen-dependent conditions, including breast cancer, cyclic breast pain and gynecomastia.

GAMOLENIC ACID

78YC2MAX4O

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

prostanoid metabolic process

Conditions:

Atopic dermatitis

Gamolenic acid also known as gamma-linolenic acid is a natural component of Oenothera biennis L. (Evening Primrose). Gamolenic acid was used for the treatment of breast painand atopic dermatitis in Europe, although now the drug is withdrawn from the ...

market (there is no safety issue associated with the withdrawal of the licences). The mechanism of action of gamolenic acid is connected with its interaction with prostanoid pathway.

HYDROXYTAMOXIFEN

95K54647BZ

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Estrogen-related receptor gamma

Estrogen receptor

Conditions:

Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen exerting estrogen receptor modulatory function. In addition, hydroxytamoxifen binds to regulates transcriptional activity of the estrogen-related receptor gamma. ASCEND Therapeutics,...

Inc. was developing TamoGel (4-hydroxytamoxifen gel) for a variety of estrogen-dependent conditions, including breast cancer, cyclic breast pain and gynecomastia.

SODIUM .GAMMA.-LINOLENATE

L4WFA9KRB5

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

prostanoid metabolic process

Conditions:

Atopic dermatitis

Gamolenic acid also known as gamma-linolenic acid is a natural component of Oenothera biennis L. (Evening Primrose). Gamolenic acid was used for the treatment of breast painand atopic dermatitis in Europe, although now the drug is withdrawn from the ...

market (there is no safety issue associated with the withdrawal of the licences). The mechanism of action of gamolenic acid is connected with its interaction with prostanoid pathway.

AFIMOXIFENE

17197F0KYM

Status:

Investigational

Class:

MIXTURE

Targets:

Estrogen-related receptor gamma

Estrogen receptor

Conditions:

Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen exerting estrogen receptor modulatory function. In addition, hydroxytamoxifen binds to regulates transcriptional activity of the estrogen-related receptor gamma. ASCEND Therapeutics,...

Inc. was developing TamoGel (4-hydroxytamoxifen gel) for a variety of estrogen-dependent conditions, including breast cancer, cyclic breast pain and gynecomastia.

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