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Details

Stereochemistry ABSOLUTE
Molecular Formula C40H56O2
Molecular Weight 568.8714
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 9
Charge 0

SHOW SMILES / InChI
Structure of ZEAXANTHIN

SMILES

CC(\C=C\C=C(C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C

InChI

InChIKey=JKQXZKUSFCKOGQ-QAYBQHTQSA-N
InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-24,35-36,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36-/m1/s1

HIDE SMILES / InChI
Molecular Formula C40H56O2
Molecular Weight 568.8714
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 9
Optical Activity UNSPECIFIED

Description

Zeaxanthin is one of the most common carotenoid alcohols found in nature. It is synthesized in plants and some micro-organisms. Lutein and Zeaxanthin are found in the macula of the human retina, as well as the human crystalline lens. They play a role in protection against age-related macular degeneration (ARMD) and cataract formation. The antioxidant properties of lutein and zeaxanthin together with ocular antioxidants (selenium, zinc, copper, vitamin A, C, E, etc.) inhibit free radical damage caused by light and oxygen. Zeaxanthin supplements are typically taken on the supposition of supporting eye health. It is is Generally Recognized As Safe by FDA.

Approval Year

2014
494
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
Lutemax 2020

Approved Use

Supports visual health and acuity by protecting against oxidative stress and inflammation.
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Distribution of lutein and zeaxanthin stereoisomers in the human retina.
1997 Feb
Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin.
1997 Jul
Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk.
1999 Aug
Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina.
2000 Apr
Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density.
2000 Jun
The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview.
2002 Mar
An efficient conversion of (3R,3'R,6'R)-lutein to (3R,3'S,6'R)-lutein (3'-epilutein) and (3R,3'R)-zeaxanthin.
2003 Jan
Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin.
2003 Mar
Serum levels of macular carotenoids in relation to age-related maculopathy: the Muenster Aging and Retina Study (MARS).
2005 Oct
Patents

Patents

JP2000069986A
1
JP2000143688A
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JP2000217572A
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JP2001002566A
1
JP2001025395A
1
JP2001025396A
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JP2001352995A
3
JP2002541193A
2
JP2003033152A
1
JP2004026720A
2
JP2004107314A
2
JP2004147506A
9
JP2004187566A
1
JP2005087097A
1
JP2005087099A
1
JP2005087100A
1
JP2005124485A
4
JP2005529885A
2
JP2006169125A
1
JP2006516396A
1
JP2007151474A
2
JP2007151475A
2
JP2007176814A
2
JP2007181451A
2
JP2007514679A
2
JP2007516697A
9
JP2007521274A
3
JP2008011824A
2
JP2008022703A
1
JP2008125511A
1
JP2008127505A
1
JP2008156349A
1
JP2008239609A
3
JP2008303166A
1
JP2009173597A
2
JP2009179628A
4
JP2009524576A
2
JP2010064984A
2
JP2010159276A
1
JP2010254687A
1
JP2010540729A
11
JP2010540730A
6
JP2011512798A
9
JP2011526486A
6
JP2014198706A
7
JP3302999B2
1
JP4601549B2
19
JP4651946B2
3
JP4659757B2
3
JP4773337B2
2
JP4834290B2
3

Sample Use Guides

In Vivo Use Guide
Dietary Supplement: Lutein/zeaxanthin 10 mg lutein and 2 mg zeaxanthin (1 tablet)
Route of Administration: Oral
In Vitro Use Guide
Zeaxanthin at 50-150 uM significantly inhibited the expression of VEGF and accumulation of HIF-1α protein caused by hypoxia but did not affect expression of VEGF and HIF-1α under normoxic conditions.in the primary culture of human retinal pigment epithelial (RPE) cells.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:59:32 UTC 2023
Edited
by admin
on Fri Dec 15 15:59:32 UTC 2023
Record UNII
CV0IB81ORO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZEAXANTHIN
INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
INS NO.161H(I)
Code English
ZEAXANTHIN [INCI]
Common Name English
ANCHOVYXANTHIN
Common Name English
(3R,3'R)-DIHYDROXY-.BETA.-CAROTENE
Common Name English
OPTISHARP
Common Name English
ZEAXANTHOL
Common Name English
E 161H
Code English
ZEAXANTHIN / (3R,3'R) - ZEAXANTHIN (CONSTITUENT OF AZTEC MARIGOLD ZEAXANTHIN EXTRACT) [DSC]
Common Name English
LUTEINOFTA
Common Name English
ZEAXANTHIN [VANDF]
Common Name English
E-161H(I)
Code English
Zeaxanthin [WHO-DD]
Common Name English
ZEAXANTHIN [MART.]
Common Name English
INS-161H(I)
Code English
AZTEC MARIGOLD ZEAXANTHIN EXTRACT [USP-RS]
Common Name English
ZEAXANTHIN [MI]
Common Name English
ZEAGOLD
Common Name English
XANTHOPHYLL 3
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-161H(I)
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
JECFA EVALUATION INS-161H(I)
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
DSLD 2326 (Number of products:1137)
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
NCI_THESAURUS C68307
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
Code System Code Type Description
GRAS Notification (GRN No.)
639
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
PUBCHEM
5280899
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
RXCUI
39918
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY RxNorm
CAS
144-68-3
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
ECHA (EC/EINECS)
205-636-4
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
WIKIPEDIA
ZEAXANTHIN
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
CHEBI
27547
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
SMS_ID
100000085226
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
NCI_THESAURUS
C68310
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
RS_ITEM_NUM
1733122
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
588
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
MERCK INDEX
m11586
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY Merck Index
DRUG BANK
DB11176
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
DAILYMED
CV0IB81ORO
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
EVMPD
SUB21930
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
FDA UNII
CV0IB81ORO
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
EPA CompTox
DTXSID5046807
Created by admin on Fri Dec 15 15:59:32 UTC 2023 , Edited by admin on Fri Dec 15 15:59:32 UTC 2023
PRIMARY
Related Record Type Details
TAGETES ERECTA FLOWER EXTRACT
PARENT -> CONSTITUENT ALWAYS PRESENT
LYCIUM BARBARUM FRUIT
PARENT -> CONSTITUENT ALWAYS PRESENT
SPIRULINA
PARENT -> ACTIVE CONSTITUENT ALWAYS PRESENT
ASSAY (HPLC)
Batch Data
CORN
PARENT -> CONSTITUENT ALWAYS PRESENT
page 594
SAFFRON
PARENT -> CONSTITUENT ALWAYS PRESENT
page 594
Structure of ZEAXANTHIN, MESO-
PARENT -> CONSTITUENT MAY BE PRESENT
USP
Related Record Type Details
Structure of LUTEIN
PARENT -> IMPURITY
USP
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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