TROCLOSENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3HCl2N3O3
Molecular Weight	197.964
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClN1C(=O)NC(=O)N(Cl)C1=O

InChI

InChIKey=CEJLBZWIKQJOAT-UHFFFAOYSA-N

InChI=1S/C3HCl2N3O3/c4-7-1(9)6-2(10)8(5)3(7)11/h(H,6,9,10)

HIDE SMILES / InChI

Molecular Formula	C3HCl2N3O3
Molecular Weight	197.964
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/61/NaDCC.pdf
Curator's Comment: description was created based on several sources, including: http://www.preciseformulation.com/nadcc-tablets-general-applications.html | http://akvopedia.org/wiki/Chlorine_(NaDCC) | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b345ae6a-0b36-45c7-b31e-2a15508a2ef5 | https://www.ncbi.nlm.nih.gov/pubmed/20064989

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diarrhea 36 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20064989 https://www.ncbi.nlm.nih.gov/pubmed/23976883	Preventing		Phase III 665	Unknown Approved Use Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2C19 2057 CYP1A2 2153 CYP19A1 429

Drug as perpetrator

Target	Modality	Activity
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 2.0	inconclusive [IC50 63.2609 uM]
CYP19A1 430	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 18.0	no
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 51.0	no
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 50.0	no
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 2.0	yes [IC50 56.3813 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 1.0	yes [IC50 56.3813 uM]

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/16726#section=BioAssay-Results Page: 49.0

PubMed

Title	Date	PubMed
Improvements to water purification and sanitation infrastructure may reduce the diarrheal burden in a marginalized and flood prone population in remote Nicaragua.	2010-12-08	21143865
Root canal irrigants.	2010-10	21217955
Field assessment of a novel household-based water filtration device: a randomised, placebo-controlled trial in the Democratic Republic of Congo.	2010-09-10	20856584
1,1'-Azobis-1,2,3-triazole: a high-nitrogen compound with stable N8 structure and photochromism.	2010-09-08	20715773
Disinfection by-product formation and mitigation strategies in point-of-use chlorination with sodium dichloroisocyanurate in Tanzania.	2010-07	20595492
Jasmonic acid and ethylene modulate local responses to wounding and simulated herbivory in Nicotiana attenuata leaves.	2010-06	20382894
Disinfection efficacy of sodium dichloroisocyanurate (NADCC) against common food-borne intestinal protozoa.	2010-04	20503596
[Specific antisepsis and environmental disinfection in preventing "Clostridium difficile associated diarrhea"].	2010-02-23	20169831
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.	2010-02-03	20128903
Sodium dichloroisocyanurate tablets for routine treatment of household drinking water in periurban Ghana: a randomized controlled trial.	2010-01	20064989
Collection of indonaphthol blue on a membrane filter for the spectrophotometric determination of ammonia with 1-naphthol and dichloroisocyanurate.	2010	20631439
A comparative study assaying commonly used sanitizers for antimicrobial activity against indicator bacteria and a Salmonella Typhimurium strain on fresh produce.	2009-11	19903410
Use of sodium dichloroisocyanurate for floor disinfection.	2009-07	19376611
Disinfection of irreversible hydrocolloid impression material with chlorinated compounds.	2009-06	19725332
Effects of pH and oil-in-water emulsions on growth and physicochemical cell surface properties of Listeria monocytogenes: Impact on tolerance to the bactericidal activity of disinfectants.	2009-03-31	19203811
Tonometer disinfection practice in the United Kingdom: a national survey.	2008-08	17464301
UV-visible marker confirms that environmental persistence of Clostridium difficile spores in toilets of patients with C. difficile-associated diarrhea is associated with lack of compliance with cleaning protocol.e.	2008-05-12	18474086
Sporicidal activity of two disinfectants against Clostridium difficile spores.	2008-04-17	18414294
Advantages of sodium hypochlorite or sodium dichloroisocyanurate disinfection for teats and bottles in newborn infants' feeding.	2008-02-26	18294178
Virucidal agents in the eve of manorapid synergy.	2007-09-13	20200679
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains.	2007-08	17620238
Analytical method for the quantitative determination of cyanuric acid as the degradation product of sodium dichloroisocyanurate in urine by liquid chromatography mass spectrometry.	2007-06-15	17409034
Comparative sporicidal effects of disinfectants after release of a biological agent.	2007-06	17615843
Household water treatment using sodium dichloroisocyanurate (NaDCC) tablets: a randomized, controlled trial to assess microbiological effectiveness in Bangladesh.	2007-01	17255252
Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.	2006-05	16640459
Sodium dichloroisocyanurate (NaDCC) tablets as an alternative to sodium hypochlorite for the routine treatment of drinking water at the household level.	2006-03	16387550
[Comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].	2006-01	16620594
[Study on the resistance of Escherichia coli O157:H7 to disinfectants in relationship with its plasmid pO157 and chromosome DNA].	2005-11	16334573
Chlorine covers on living bacteria: the initial step in antimicrobial action of active chlorine compounds.	2005-04	15761074
Flow-injection potentiometric determination of triiodide by plasticized poly(vinyl chloride) membrane electrodes and its application to the determination of chlorine-containing disinfectants.	2005-03-15	18969930
The effect of a range of disinfectants on the dimensional accuracy of some impression materials.	2004-12	15691188
Soft tissue dissolution capacity of currently used and potential endodontic irrigants.	2004-11	15505511
The effect of sterilization methods on the light transmission characteristics and structure of light-curing tips.	2004-09	15369476
Efficacy of three surface disinfectants for dental radiographic films and gloves.	2004-07	15193787
The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces.	2004-06	15183245
Flow-injection determination of isoniazid using sodium dichloroisocyanurate- and trichloroisocyanuric acid-luminol chemiluminescence systems.	2004-06	15178311
[Bioactive effectiveness of selected disinfective agents on Gram-negative bacilli isolated from hospital environment].	2004	15810507
Resistance of spheroplasts and whole cells of Pseudomonas aeruginosa to bactericidal activity of various biocides: evidence of the membrane implication.	2004	15160607
Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes.	2003-10-17	14563217
Effects of different disinfection treatments on the natural microbiota of lettuce.	2003-09	14503728
Determination of ammonia in beers by pervaporation flow injection analysis and spectrophotometric detection.	2003-08-29	18969154
The effect of potassium permanganate and sodium dichloroisocyanurate on metacercariae of Fasciola gigantica.	2003-04	12739819
Flow-injection chemiluminescence determination of chlorinated isocyanuric acids.	2003-02	12589508
Sanichlor-induced atopic dermatitis and asthma in ophthalmologists.	2003-01	12579187
Flow injection chemiluminescence determination of hydrazine by oxidation with chlorinated isocyanurates.	2002-10-16	18968808
Germicidal activities of representatives of five different teat dip classes against three bovine mycoplasma species using a modified excised teat model.	2002-08	12214982
Preventing infection from reusable medical equipment: a systematic review.	2002-03-27	11916458
Reduction of mastitis caused by experimental challenge with Staphylococcus aureus and Streptococcus agalactiae by use of a quaternary ammonium and halogen-mixture teat dip.	2002-01	11860119
[Sodium dichloroisocyanurate: a major disinfectant for drinking water].	2002	12731302
Life threatening airway obstruction in a newborn following ingestion of sterilising tablet.	2001-11	11676435

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Viral suspensions were prepared containing 10(4)-10(5) syncitial forming units ml-1 in 0.9% saline or 0.9% saline containing 10% v/v plasma to simulate clean and dirty conditions. A syncitial inhibition assay on C8166 lymphoblastoid line was used to determine viral titre. Results indicate that satisfactory disinfection (3-4 log reduction in 2 min) can be achieved using Troclosene and NaOCl at concentrations of 50 ppm and 2500 ppm available chlorine (AvCl2) for clean and soiled conditions respectively. For treatment of blood spillages, the addition of Troclosene and NaOCl solutions (10,000 ppm) to equal volumes of contaminated blood (giving a final AvCl2 concentration of 5000 ppm of blood) was sufficient to produce total kill within 2 min.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:36:57 GMT 2025` Edited by `admin` on `Mon Mar 31 18:36:57 GMT 2025`
Record UNII	PHR838Y52L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TROCLOSENE [HSDB]

Preferred Name

English

TROCLOSENE

Common Name

English

DICHLOROISOCYANURIC ACID

Systematic Name

English

DICHLORO-1,3,5-TRIAZINETRIONE

Systematic Name

English

DICHLOROCYANURIC ACID

Systematic Name

English

Troclosene [WHO-DD]

Common Name

English

1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-

Systematic Name

English

1,3-DICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)TRIONE

Systematic Name

English

S-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-

Systematic Name

English

DICHLORO-S-TRIAZINE-2,4,6-TRIONE

Systematic Name

English

TROCLOSENE [MART.]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

81401