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Details

Stereochemistry ACHIRAL
Molecular Formula C3HCl2N3O3
Molecular Weight 197.964
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TROCLOSENE

SMILES

ClN1C(=O)NC(=O)N(Cl)C1=O

InChI

InChIKey=CEJLBZWIKQJOAT-UHFFFAOYSA-N
InChI=1S/C3HCl2N3O3/c4-7-1(9)6-2(10)8(5)3(7)11/h(H,6,9,10)

HIDE SMILES / InChI

Molecular Formula C3HCl2N3O3
Molecular Weight 197.964
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.preciseformulation.com/nadcc-tablets-general-applications.html | http://akvopedia.org/wiki/Chlorine_(NaDCC) | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b345ae6a-0b36-45c7-b31e-2a15508a2ef5 | https://www.ncbi.nlm.nih.gov/pubmed/20064989

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
The efficacy of chemical agents in cleaning and disinfection programs.
2001
Life threatening airway obstruction in a newborn following ingestion of sterilising tablet.
2001 Nov
Germicidal activities of representatives of five different teat dip classes against three bovine mycoplasma species using a modified excised teat model.
2002 Aug
Reduction of mastitis caused by experimental challenge with Staphylococcus aureus and Streptococcus agalactiae by use of a quaternary ammonium and halogen-mixture teat dip.
2002 Jan
[Bioactive effectiveness of selected disinfective agents on Gram-negative bacilli isolated from hospital environment].
2004
The effect of a range of disinfectants on the dimensional accuracy of some impression materials.
2004 Dec
The effect of sterilization methods on the light transmission characteristics and structure of light-curing tips.
2004 Sep
Chlorine covers on living bacteria: the initial step in antimicrobial action of active chlorine compounds.
2005 Apr
[Study on the resistance of Escherichia coli O157:H7 to disinfectants in relationship with its plasmid pO157 and chromosome DNA].
2005 Nov
[Comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].
2006 Jan
Sodium dichloroisocyanurate (NaDCC) tablets as an alternative to sodium hypochlorite for the routine treatment of drinking water at the household level.
2006 Mar
Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.
2006 May
Analytical method for the quantitative determination of cyanuric acid as the degradation product of sodium dichloroisocyanurate in urine by liquid chromatography mass spectrometry.
2007 Jun 15
Virucidal agents in the eve of manorapid synergy.
2007 Sep 13
UV-visible marker confirms that environmental persistence of Clostridium difficile spores in toilets of patients with C. difficile-associated diarrhea is associated with lack of compliance with cleaning protocol.e.
2008 May 12
Disinfection of irreversible hydrocolloid impression material with chlorinated compounds.
2009 Jun
[Specific antisepsis and environmental disinfection in preventing "Clostridium difficile associated diarrhea"].
2009 Nov-Dec
Disinfection efficacy of sodium dichloroisocyanurate (NADCC) against common food-borne intestinal protozoa.
2010 Apr
Improvements to water purification and sanitation infrastructure may reduce the diarrheal burden in a marginalized and flood prone population in remote Nicaragua.
2010 Dec 8
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.
2010 Feb 3
Disinfection by-product formation and mitigation strategies in point-of-use chlorination with sodium dichloroisocyanurate in Tanzania.
2010 Jul
Jasmonic acid and ethylene modulate local responses to wounding and simulated herbivory in Nicotiana attenuata leaves.
2010 Jun
Root canal irrigants.
2010 Oct
Field assessment of a novel household-based water filtration device: a randomised, placebo-controlled trial in the Democratic Republic of Congo.
2010 Sep 10
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Viral suspensions were prepared containing 10(4)-10(5) syncitial forming units ml-1 in 0.9% saline or 0.9% saline containing 10% v/v plasma to simulate clean and dirty conditions. A syncitial inhibition assay on C8166 lymphoblastoid line was used to determine viral titre. Results indicate that satisfactory disinfection (3-4 log reduction in 2 min) can be achieved using Troclosene and NaOCl at concentrations of 50 ppm and 2500 ppm available chlorine (AvCl2) for clean and soiled conditions respectively. For treatment of blood spillages, the addition of Troclosene and NaOCl solutions (10,000 ppm) to equal volumes of contaminated blood (giving a final AvCl2 concentration of 5000 ppm of blood) was sufficient to produce total kill within 2 min.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:50:10 GMT 2023
Edited
by admin
on Fri Dec 15 16:50:10 GMT 2023
Record UNII
PHR838Y52L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TROCLOSENE
HSDB   MART.   WHO-DD  
Common Name English
DICHLOROISOCYANURIC ACID
Systematic Name English
DICHLORO-1,3,5-TRIAZINETRIONE
Systematic Name English
DICHLOROCYANURIC ACID
Systematic Name English
TROCLOSENE [HSDB]
Common Name English
Troclosene [WHO-DD]
Common Name English
1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-
Systematic Name English
1,3-DICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)TRIONE
Systematic Name English
S-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-
Systematic Name English
DICHLORO-S-TRIAZINE-2,4,6-TRIONE
Systematic Name English
TROCLOSENE [MART.]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 81401
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
Code System Code Type Description
PUBCHEM
16726
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
CAS
2782-57-2
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
HSDB
5897
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
EPA CompTox
DTXSID8024993
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
MESH
C011765
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
RXCUI
1537576
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
Dichloroisocyanuric acid
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
FDA UNII
PHR838Y52L
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
ECHA (EC/EINECS)
220-487-5
Created by admin on Fri Dec 15 16:50:10 GMT 2023 , Edited by admin on Fri Dec 15 16:50:10 GMT 2023
PRIMARY
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ACTIVE MOIETY