TROCLOSENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3HCl2N3O3
Molecular Weight	197.964
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClN1C(=O)NC(=O)N(Cl)C1=O

InChI

InChIKey=CEJLBZWIKQJOAT-UHFFFAOYSA-N

InChI=1S/C3HCl2N3O3/c4-7-1(9)6-2(10)8(5)3(7)11/h(H,6,9,10)

HIDE SMILES / InChI

Molecular Formula	C3HCl2N3O3
Molecular Weight	197.964
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/61/NaDCC.pdf
Curator's Comment: description was created based on several sources, including: http://www.preciseformulation.com/nadcc-tablets-general-applications.html | http://akvopedia.org/wiki/Chlorine_(NaDCC) | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b345ae6a-0b36-45c7-b31e-2a15508a2ef5 | https://www.ncbi.nlm.nih.gov/pubmed/20064989

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diarrhea 35 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20064989 https://www.ncbi.nlm.nih.gov/pubmed/23976883	Preventing		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
The efficacy of chemical agents in cleaning and disinfection programs.	2001	11591223
Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro.	2001 Apr	11485267
Sanichlor-induced atopic dermatitis and asthma in ophthalmologists.	2003 Jan	12579187
Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes.	2003 Oct 17	14563217
Resistance of spheroplasts and whole cells of Pseudomonas aeruginosa to bactericidal activity of various biocides: evidence of the membrane implication.	2004	15160607
Efficacy of three surface disinfectants for dental radiographic films and gloves.	2004 Jul	15193787
Chlorine covers on living bacteria: the initial step in antimicrobial action of active chlorine compounds.	2005 Apr	15761074
[Comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].	2006 Jan	16620594
Household water treatment using sodium dichloroisocyanurate (NaDCC) tablets: a randomized, controlled trial to assess microbiological effectiveness in Bangladesh.	2007 Jan	17255252
Comparative sporicidal effects of disinfectants after release of a biological agent.	2007 Jun	17615843
Sporicidal activity of two disinfectants against Clostridium difficile spores.	2008 Mar 13-26	18414294
Effects of pH and oil-in-water emulsions on growth and physicochemical cell surface properties of Listeria monocytogenes: Impact on tolerance to the bactericidal activity of disinfectants.	2009 Mar 31	19203811
Disinfection efficacy of sodium dichloroisocyanurate (NADCC) against common food-borne intestinal protozoa.	2010 Apr	20503596
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.	2010 Feb 3	20128903
Sodium dichloroisocyanurate tablets for routine treatment of household drinking water in periurban Ghana: a randomized controlled trial.	2010 Jan	20064989
Root canal irrigants.	2010 Oct	21217955

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Viral suspensions were prepared containing 10(4)-10(5) syncitial forming units ml-1 in 0.9% saline or 0.9% saline containing 10% v/v plasma to simulate clean and dirty conditions. A syncitial inhibition assay on C8166 lymphoblastoid line was used to determine viral titre. Results indicate that satisfactory disinfection (3-4 log reduction in 2 min) can be achieved using Troclosene and NaOCl at concentrations of 50 ppm and 2500 ppm available chlorine (AvCl2) for clean and soiled conditions respectively. For treatment of blood spillages, the addition of Troclosene and NaOCl solutions (10,000 ppm) to equal volumes of contaminated blood (giving a final AvCl2 concentration of 5000 ppm of blood) was sufficient to produce total kill within 2 min.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:50:10 UTC 2023` Edited by `admin` on `Fri Dec 15 16:50:10 UTC 2023`
Record UNII	PHR838Y52L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TROCLOSENE

Common Name

English

DICHLOROISOCYANURIC ACID

Systematic Name

English

DICHLORO-1,3,5-TRIAZINETRIONE

Systematic Name

English

DICHLOROCYANURIC ACID

Systematic Name

English

TROCLOSENE [HSDB]

Common Name

English

Troclosene [WHO-DD]

Common Name

English

1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-

Systematic Name

English

1,3-DICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)TRIONE

Systematic Name

English

S-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-

Systematic Name

English

DICHLORO-S-TRIAZINE-2,4,6-TRIONE

Systematic Name

English

TROCLOSENE [MART.]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

81401