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Details

Stereochemistry ABSOLUTE
Molecular Formula C40H56O2
Molecular Weight 568.8714
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 9
Charge 0

SHOW SMILES / InChI
Structure of ZEAXANTHIN

SMILES

CC(\C=C\C=C(C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C

InChI

InChIKey=JKQXZKUSFCKOGQ-QAYBQHTQSA-N
InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-24,35-36,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36-/m1/s1

HIDE SMILES / InChI

Description

Zeaxanthin is one of the most common carotenoid alcohols found in nature. It is synthesized in plants and some micro-organisms. Lutein and Zeaxanthin are found in the macula of the human retina, as well as the human crystalline lens. They play a role in protection against age-related macular degeneration (ARMD) and cataract formation. The antioxidant properties of lutein and zeaxanthin together with ocular antioxidants (selenium, zinc, copper, vitamin A, C, E, etc.) inhibit free radical damage caused by light and oxygen. Zeaxanthin supplements are typically taken on the supposition of supporting eye health. It is is Generally Recognized As Safe by FDA.

Approval Year

2014
494
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
Lutemax 2020

Approved Use

Supports visual health and acuity by protecting against oxidative stress and inflammation.
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Identification of lutein and zeaxanthin oxidation products in human and monkey retinas.
1997 Aug
Distribution of lutein and zeaxanthin stereoisomers in the human retina.
1997 Feb
Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin.
1997 Jul
Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density.
2000 Jun
Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin.
2003 Mar
Synergistic effects of zeaxanthin and its binding protein in the prevention of lipid membrane oxidation.
2005 May 30
Serum levels of macular carotenoids in relation to age-related maculopathy: the Muenster Aging and Retina Study (MARS).
2005 Oct
Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cells.
2006 Mar
A 12-wk egg intervention increases serum zeaxanthin and macular pigment optical density in women.
2006 Oct
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.
2011 Mar
Patents

Patents

JP2000069986A
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JP2000143688A
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JP2000217572A
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JP2001002566A
1
JP2001025395A
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JP2001025396A
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JP2001352995A
3
JP2002541193A
2
JP2003033152A
1
JP2004026720A
2
JP2004107314A
2
JP2004147506A
9
JP2004187566A
1
JP2005087097A
1
JP2005087099A
1
JP2005087100A
1
JP2005124485A
4
JP2005529885A
2
JP2006169125A
1
JP2006516396A
1
JP2007151474A
2
JP2007151475A
2
JP2007176814A
2
JP2007181451A
2
JP2007514679A
2
JP2007516697A
9
JP2007521274A
3
JP2008011824A
2
JP2008022703A
1
JP2008125511A
1
JP2008127505A
1
JP2008156349A
1
JP2008239609A
3
JP2008303166A
1
JP2009173597A
2
JP2009179628A
4
JP2009524576A
2
JP2010064984A
2
JP2010159276A
1
JP2010254687A
1
JP2010540729A
11
JP2010540730A
6
JP2011512798A
9
JP2011526486A
6
JP2014198706A
7
JP3302999B2
1
JP4601549B2
19
JP4651946B2
3
JP4659757B2
3
JP4773337B2
2
JP4834290B2
3

Sample Use Guides

In Vivo Use Guide
Dietary Supplement: Lutein/zeaxanthin 10 mg lutein and 2 mg zeaxanthin (1 tablet)
Route of Administration: Oral
In Vitro Use Guide
Zeaxanthin at 50-150 uM significantly inhibited the expression of VEGF and accumulation of HIF-1α protein caused by hypoxia but did not affect expression of VEGF and HIF-1α under normoxic conditions.in the primary culture of human retinal pigment epithelial (RPE) cells.
Name Type Language
ZEAXANTHIN
INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
INS NO.161H(I)
Code English
ZEAXANTHIN [INCI]
Common Name English
ANCHOVYXANTHIN
Common Name English
(3R,3'R)-DIHYDROXY-.BETA.-CAROTENE
Common Name English
OPTISHARP
Common Name English
ZEAXANTHOL
Common Name English
E 161H
Code English
ZEAXANTHIN / (3R,3'R) - ZEAXANTHIN (CONSTITUENT OF AZTEC MARIGOLD ZEAXANTHIN EXTRACT) [DSC]
Common Name English
LUTEINOFTA
Common Name English
ZEAXANTHIN [VANDF]
Common Name English
E-161H(I)
Code English
Zeaxanthin [WHO-DD]
Common Name English
ZEAXANTHIN [MART.]
Common Name English
INS-161H(I)
Code English
AZTEC MARIGOLD ZEAXANTHIN EXTRACT [USP-RS]
Common Name English
ZEAXANTHIN [MI]
Common Name English
ZEAGOLD
Common Name English
XANTHOPHYLL 3
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-161H(I)
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
JECFA EVALUATION INS-161H(I)
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
DSLD 2326 (Number of products:1137)
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
NCI_THESAURUS C68307
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
Code System Code Type Description
GRAS Notification (GRN No.)
639
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
PUBCHEM
5280899
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
RXCUI
39918
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY RxNorm
CAS
144-68-3
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-636-4
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
WIKIPEDIA
ZEAXANTHIN
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
CHEBI
27547
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
SMS_ID
100000085226
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
NCI_THESAURUS
C68310
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
RS_ITEM_NUM
1733122
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
588
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
MERCK INDEX
m11586
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB11176
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
DAILYMED
CV0IB81ORO
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
EVMPD
SUB21930
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
FDA UNII
CV0IB81ORO
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID5046807
Created by admin on Fri Dec 15 15:59:32 GMT 2023 , Edited by admin on Fri Dec 15 15:59:32 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of ZEAXANTHIN
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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