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Magnesium oleate is a food additive, anticaking and emulsifying agent. It has also being shown that environmentally friendly multifunctional metal (magnesium) oleate detergent with antioxidation property has good potential for application in synthesizing a variety of substrate detergents.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Potassium propionate is the potassium salt of propionic acid. It is used as an antimicrobial agent in bread to prevent germination of some types of bacteria which causes sticky yellow patches to occur. Has been linked with behavioural and learning problems, migraines, headaches and can cause asthma. Potassium propionate is represented by the food labeling E number E283 in Europe and by the INS number 283 in Australia and New Zealand. It is very effective against molds and rope forming bacteria and is preferred in chemically leavened cakes, tortillas, pie fillings. Since Probake® Potassium Propionate does not add sodium to the product, it is very suitable for low-salt recipes. A typical dosage for potassium propionate in bakery products is 0.3%. Probake Potassium Propionate is available as a dust free agglomerate grade. GRAS.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Pimpinellin is a furocoumarin and mevalonic acid derivative, that was isolated from Heracleum laciniatum and Toddalia asiatica. Pimpinellin, isopimpinellin and phellopterin are three major coumarins present in Toddalia asiatica extract which demonstrated activities like anticancer, vasodilative and antioxidant etc Pimpinellin is well known photoreactive compound and it is used in Brazil in some pharmaceutical and cosmetic products because of their UV-light absorbing properties
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
SCH-23390 is a potent and selective antagonist of the D1A and D1B dopamine receptors having Ki of 0.2 and 0.3 nM respectively. The C11 radiolabeled version has proven to be useful as a PET imaging probe in humans for the investigation of a number of neurological conditions including Schizophrenia, Parkinson's Disease, and Huntington's Disease. It should be noted that the non-radiolabeled compound did receive preclinical interest as a potential therapeutic (annotated separately), although such efforts have been discontinued due to side-effects and a lack of therapeutic efficacy.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Sanguinarine is a toxic polycyclic quaternary ammonium salt. It is extracted from some plants, including bloodroot (Sanguinaria canadensis), Mexican prickly poppy Argemone mexicana, Chelidonium majus and Macleaya cordata. Sanguinarine is a toxin that kills animal cells through its action on the Na+-K+-ATPase transmembrane protein. If applied to the skin, sanguinarine may cause a massive scab of dead flesh, called an eschar. For this reason, sanguinarine is termed an escharotic. Preliminary pre-clinical in vitro and in vivo studies have demonstrated that sanguinarine causes apoptosis in human cancer cells, and recommend study of sanguinarine as a potential cancer treatment. Sanguinarine has been the subject of other medical fields as well. For instance, it has garnered interest as a chemical defense against microorganisms and viruses. Notably, experiments on human plaque accumulation in the presence of sanguinarine suggest the toxin may be effective against oral microbial isolates. However, no products containing sanguinarine are currently approved by the FDA for the treatment of cancer; the FDA warns that unapproved bloodroot preparations are ineffective and dangerous.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Sodium aurothiomalate (also known as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects. It was indicated in the treatment of selected cases of active rheumatoid arthritis—both adult and juvenile type. The greatest benefit occurs in the early active stage. In late stages of the illness when cartilage and bone damage have occurred, gold can only check the progression of rheumatoid arthritis and prevent further structural damage to joints. It cannot repair damage caused by previously active disease. Gold Sodium Thiomalate should be used only as one part of a complete program of therapy; alone it is not a complete treatment. The mode of action is unknown, but was found, that aurothiomalate is able to inhibit Microsomal prostaglandin E synthase-1 (mPGES-1 expression. mPGES-1 is a terminal enzyme in the production of prostaglandin E2 (PGE2) and its expression is upregulated during inflammation. mPGES-1 is considered as a potential drug target for the treatment of arthritis to reduce adverse effects related to the current non-steroidal anti-inflammatory drugs (NSAIDs).
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dimethocaine (DMC, larocaine), a synthetic derivative of cocaine, is a widely distributed "legal high" consumed as a "new psychoactive substance" (NPS), originally was used in the 1930s as an anesthetic, primarily in dentistry, ophthalmology, and otolaryngology. This drug completely inhibits dopamine transporter and has had the potential for abuse. Dimethocaine is intended for forensic and research purposes.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Azomycin (2-Nitroimidazole) is a natural antimicrobial antibiotic produced by a strain of Nocardia mesenterica, that have been used to combat anaerobic bacterial and parasitic infections. Azomycin and other 2’-nitroimidazoles show anti-ischemic and anti-inflammatory pharmacological properties. Azomycin is cytotoxic and change drug-metabolizing cytochrome P450, NADPH dependent reductase enzymes and cause depletion of tissue oxygen pressure. Azomycin is a prodrug. Unionized Azomycin is selective for anaerobic bacteria due to their ability to intracellularly reduce Azomycin to its active form. This reduced Azomycin then covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Galangin is a flavanol that is found in high concentrations in Alpinia officinarum and Helichrysum aureonitens. It can also be found in the rhizome of Alpinia galanga and in propolis. Galangin has been shown to have antibacterial, antiviral, anticancer and neuroprotective properties in vitro and in animal models.
Erythromycin Oxime is the major metabolite of Roxithromycin which is also an intermediate of Azithromycin. It exhibits antibacterial properties and is also Roxithromycin impurity C.