ERYTHROMYCIN OXIME

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C37H68N2O13
Molecular Weight	748.9414
Optical Activity	UNSPECIFIED
Defined Stereocenters	18 / 18
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]2[C@H](C)[C@@H](O[C@]3([H])O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=NO)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C

InChI

InChIKey=KYTWXIARANQMCA-RWJQBGPGSA-N

InChI=1S/C37H68N2O13/c1-14-25-37(10,45)30(41)20(4)27(38-46)18(2)16-35(8,44)32(52-34-28(40)24(39(11)12)15-19(3)48-34)21(5)29(22(6)33(43)50-25)51-26-17-36(9,47-13)31(42)23(7)49-26/h18-26,28-32,34,40-42,44-46H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/833239 | https://www.trc-canada.com/product-detail/?E650010

Erythromycin Oxime is the major metabolite of Roxithromycin which is also an intermediate of Azithromycin. It exhibits antibacterial properties and is also Roxithromycin impurity C.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 234 Sources: https://www.scbt.com/scbt/product/erythromycin-oxime-13127-18-9	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Erythromycin VI: kinetics of acid-catalyzed hydrolysis of erythromycin oxime and erythromycylamine.	1978 Jul	660496
Metabolism of roxithromycin in phenobarbital-treated rat liver microsomes.	2002 May	11978197
Synthesis of two and antibacterial activity of one novel oxime ether derivatives of erythromycin A.	2003 Oct	14505731

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

ERYTHROMYCIN OXIME

Common Name

English

ERYTHROMYCIN, 9-OXIME

Common Name

English

Erythromycin oxime [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C261