POTASSIUM PROPIONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H5O2.K
Molecular Weight	112.1689
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].CCC([O-])=O

InChI

InChIKey=BWILYWWHXDGKQA-UHFFFAOYSA-M

InChI=1S/C3H6O2.K/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: https://www.food.gov.uk/science/additives/enumberlist | https://www.ulprospector.com/en/na/Food/Detail/1005/595147/Probake-Potassium-Propionate | https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=IndirectAdditives&id=POTASSIUMPROPIONATE

Potassium propionate is the potassium salt of propionic acid. It is used as an antimicrobial agent in bread to prevent germination of some types of bacteria which causes sticky yellow patches to occur. Has been linked with behavioural and learning problems, migraines, headaches and can cause asthma. Potassium propionate is represented by the food labeling E number E283 in Europe and by the INS number 283 in Australia and New Zealand. It is very effective against molds and rope forming bacteria and is preferred in chemically leavened cakes, tortillas, pie fillings. Since Probake® Potassium Propionate does not add sodium to the product, it is very suitable for low-salt recipes. A typical dosage for potassium propionate in bakery products is 0.3%. Probake Potassium Propionate is available as a dust free agglomerate grade. GRAS.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Allium cepa 1 Target ID: CHEMBL613790 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18328610	Inhibitor 8297
acetylcholine metabolic process 11 Target ID: GO:0008291 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6324040 \| https://www.ncbi.nlm.nih.gov/pubmed/2784707 \| https://www.ncbi.nlm.nih.gov/pubmed/2789283	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Postoperative complications 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14158607 https://www.ncbi.nlm.nih.gov/pubmed/5905378	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effect of potassium propionate on free and bound acetylcholine in frog muscle.	1989 Jan 16	2784707
Effects of intraruminal infusion of sodium, potassium, and ammonium on hypophagia from propionate in lactating dairy cows.	2003 Apr	12741564
Evaluation of genotoxic effects of sodium propionate, calcium propionate and potassium propionate on the root meristem cells of Allium cepa.	2008 Jun	18328610
Comparative Efficacy of Potassium Levulinate with and without Potassium Diacetate and Potassium Propionate versus Potassium Lactate and Sodium Diacetate for Control of Listeria monocytogenes on Commercially Prepared Uncured Turkey Breast.	2015 May	25951386

Patents

Sample Use Guides

In Vivo Use Guide

Dairy cows: Treatment was intraruminal infusion of potassium propionate 0.93 M. Treatment solution was infused over 14 h starting 2 h before feeding at 17.9 ml/min, which is equivalent to 16.7 mmol/min.

Route of Administration: Other

In Vitro Use Guide

Five concentrations of Potassium propionate - 1000, 1500, 2000, 2500, and 3000ppm - were applied for 24, 48, and 72h. All concentrations of Potassium propionate showed an inhibitory effect on cell division in root-tips of A. cepa and caused a decrease in mitotic index values.

Name

Type

Language

POTASSIUM PROPIONATE

Official Name

English

INS-283

Code

English

PROPIONIC ACID, POTASSIUM SALT

Common Name

English

INS NO. 283

Code

English

POTASSIUM PROPIONATE [INCI]

Common Name

English

POTASSIUM PROPANOATE

Systematic Name

English

E-283

Code

English

Classification Tree Code System Code

JECFA EVALUATION

INS-283