| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.2369 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC2=C(C(=O)C(O)=C(O2)C3=CC=CC=C3)C(O)=C1
InChI
InChIKey=VCCRNZQBSJXYJD-UHFFFAOYSA-N
InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
Galangin is a flavanol that is found in high concentrations in Alpinia officinarum and Helichrysum aureonitens. It can also be found in the rhizome of Alpinia galanga and in propolis. Galangin has been shown to have antibacterial, antiviral, anticancer and neuroprotective properties in vitro and in animal models.
CNS Activity
Originator
Approval Year
Sample Use Guides
Specific-pathogen-free BALB/c mice aged 6-8 weeks were sensitized on days 0, 7 and 14 by intraperitoneal injection of 20 micro-g ovalbumin (OVA) emulsified in 2 mg of aluminum hydroxide gel in a total volume of 200 micro-L. Sensitised mice were exposed to aerosolized 5% OVA in sterile saline for 8 weeks beginning on day 16 for 30 min three times a week. Galangin at a dose of 0.1 or 0.5 mg/kg was administered 30 min before nebulized OVA.
Route of Administration:
Unknown
Human MCF-7 cells were grown in RPMI-1640 media supplemented with 2 mM glutamine and 10% fetal bovine serum. Cells were sub-cultured weekly using 0.25% trypsin and 0.05% EDTA. All cultures were incubated at 37 deg-C under a 5% CO2 atmosphere. MCF-& cells in 175 cm^2 flasks were incubated in 12 mL of growth medium containing 0.1 micro-g/mL [3H]DMBA in the presence of DMSO, 1 micro-M galangin, or 10 micro-M galangin. After 24 hours, 1 mL of the medium was removed and extracted with 1 mL of ethyl acetate. [3H]DMBA was separated from metabolites and counted by scintilation.
SUBSTANCE RECORD
