Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H10O5 |
| Molecular Weight | 246.2155 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2OC=CC2=C3OC(=O)C=CC3=C1OC
InChI
InChIKey=BQPRWZCEKZLBHL-UHFFFAOYSA-N
InChI=1S/C13H10O5/c1-15-11-7-3-4-9(14)18-10(7)8-5-6-17-12(8)13(11)16-2/h3-6H,1-2H3
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21214482 | https://www.ncbi.nlm.nih.gov/pubmed/10719903 | https://www.ncbi.nlm.nih.gov/pubmed/24257925 |
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21214482 | https://www.ncbi.nlm.nih.gov/pubmed/10719903 | https://www.ncbi.nlm.nih.gov/pubmed/24257925 |
Pimpinellin is a furocoumarin and mevalonic acid derivative, that was isolated from Heracleum laciniatum and Toddalia asiatica. Pimpinellin, isopimpinellin and phellopterin are three major coumarins present in Toddalia asiatica extract which demonstrated activities like anticancer, vasodilative and antioxidant etc Pimpinellin is well known photoreactive compound and it is used in Brazil in some pharmaceutical and cosmetic products because of their UV-light absorbing properties
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The furanocoumarins in the roots of Heracleum sibiricum L. | 2003 Sep-Oct |
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| A pimpinellin monomer and dimer isolated from the roots of Esenbeckia grandiflora. | 2004 Dec |
|
| Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. | 2004 May-Jun |
|
| Phytophotodermatitis in Rijeka region, Croatia. | 2008 Oct |
|
| Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS. | 2008 Oct |
|
| Simultaneous and sensitive determination of xanthotoxin, psoralen, isoimpinellin and bergapten in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. | 2010 Feb 15 |
|
| The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. | 2013 May 2 |
Patents
Sample Use Guides
20 mkl of 0.25% absolute alcoholic solutions were applied to the back for 1 hour by the l inn chamber method
Route of Administration:
Topical
Pimpinellin isolated from the Traditional Chinese medicine was studied for their antitumor activity in vitro by determining the inhibitory percentage against growth of human epidermal carcinoma cell line A432 and human mammary cancer cell line BCAP, respectively. Pimpinellin inhibited growth of human epidermal carcinoma cell line A432 with IC50=73mkM
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SUBSTANCE RECORD
