Imidacloprid is a systemic, chloro-nicotinyl insecticide used for the control of sucking insects such as fleas, aphids, whiteflies, termites, turf insects, soil insects, and some beetles. It is used on co on and vegetable crops as foliar and seed treatments, soil, structures, indoor and outdoor insect control, home gardening and pet products. It is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. It kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). It is also indicated for the treatment and control of the following intestinal parasites Hookworm species, Roundworm species, Whipworms. Adverse events in animals included: malaise, vomiting, diarrhea, shaking, mydriasis, hypersalivation with abnormal neurologic signs, seizures, death, generalized hematoma of the body, and alopecia at the treatment site. Adverse reactions in humans included: burning, tingling, numbness, bad taste in the mouth, dizziness, and headache.

Sucralose (sold commercially as Splenda), a water-soluble chlorocarbohydrate, is a sweetener used to sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. In the European Union, it is also known under the E number E955. It is approved in USA by FDA under Chapter I-Food and Drug administration as a multipurpose additive permitted for direct addition to food for human consumption. Splenda is stated to be safe for use by subjects with type 2 diabetes since it does not effect glucose homeostasis in these patients. There is one ongoing clinical trial on effect and safety of sucralose in patients with type 2 diabetes in intensive insulin therapy.

Embutramide is a veterinary, CNS active medicine used for euthanasia in dogs. The drug is marketed under the name Tributame in the USA and under the name Tanax in Europe. Human consumption of the drug is usually associated with suicide attempts.

Dipyrithione is a pyrithione derivate used as bactericide and fungicide. The drug was marketed under the name Crimanex in the form of shampoo for the treatment of dandruff, however it is no longer available on the manufacturer website (Drossa Pharm).

Romifidine is an alpha2-adrenergic agonist, which as a sedative and analgesic in horses. The drug was approved by FDA under the name Sedivet. It has no use in humans.

Cyclomethicone 5 (D5) is a clear, alcohol-free and odorless liquid, added to personal skin care products to give them a smoother texture that is more easily applied to the skin. Cyclomethicone 5 is member of cyclomethicone, which are a group of liquid methyl siloxanes that have low viscosity and high volatility. Because molecules of this chemical are too large to enter human pores, and don’t tend to block the active ingredients from entering the skin, cyclomethicone is a commonly used as a skin emollient ingredient. Cyclomethicone 5 can cause minor skin and eye irritation. Some DNA damage has been reported in mouse lymphoma cell assays, and uterine carcinogenicity of Cyclomethicone 5 reported in rats after long‐term exposure. Reduced levels of mRNAs for other DNA repair proteins in human breast epithelial cells were also observed after exposure to Cyclomethicone 5. Cyclomethicone 5 has been defined as a very persistent very bioaccumulative (vPvB) substance of environmental concern, which has led to the submission of a proposal for their restriction in Europe.