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Details

Stereochemistry ACHIRAL
Molecular Formula C10H8N2O2S2
Molecular Weight 252.313
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPYRITHIONE

SMILES

[O-][N+]1=CC=CC=C1SSC2=CC=CC=[N+]2[O-]

InChI

InChIKey=ZHDBTKPXEJDTTQ-UHFFFAOYSA-N
InChI=1S/C10H8N2O2S2/c13-11-7-3-1-5-9(11)15-16-10-6-2-4-8-12(10)14/h1-8H

HIDE SMILES / InChI
Molecular Formula C10H8N2O2S2
Molecular Weight 252.313
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dipyrithione is a pyrithione derivate used as bactericide and fungicide. The drug was marketed under the name Crimanex in the form of shampoo for the treatment of dandruff, however it is no longer available on the manufacturer website (Drossa Pharm).

Approval Year

2006
190
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
CRIMANEX

Approved Use

To treat dandruff.
Doses

Doses

DosePopulationAdverse events​
400 mg/m2 single, topical
Highest studied dose
Dose: 400 mg/m2
Route: topical
Route: single
Dose: 400 mg/m2
Sources:
https://pubmed.ncbi.nlm.nih.gov/898185/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/898185/
Sources:
https://pubmed.ncbi.nlm.nih.gov/898185/
PubMed

PubMed

TitleDatePubMed
New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.
2014-02-03
Toxicity of metal pyrithione photodegradation products to marine organisms with indirect evidence for their presence in seawater.
2010-05
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
2009-03-27
Patents

Patents

JPH06100405A
3
JPS5212207A
3
JPS5478733A
3
JPS61186301A
3

Sample Use Guides

In Vivo Use Guide
To wash you head with the shampoo 1 or 2 times per week.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:45:10 GMT 2025
Edited
by admin
on Mon Mar 31 17:45:10 GMT 2025
Record UNII
9L87N86R9A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BISPYRITHIONE
INCI  
INCI  
Preferred Name English
DIPYRITHIONE
INN   MART.   USAN  
USAN   INN  
Official Name English
NSC-241716
Code English
OMADINE DISULFIDE
Common Name English
PYRITHIONE DISULFIDE
Common Name English
NSC-84740
Code English
2,2'-DITHIOBIS(PYRIDINE) 1,1'-DIOXIDE
Common Name English
DIPYRITHIONE [MART.]
Common Name English
DI-2-PYRIDYL DISULFIDE 1,1'-DIOXIDE
Common Name English
dipyrithione [INN]
Common Name English
DIPYRITHIONE [USAN]
Common Name English
PYRITHIONE DISULPHIDE
Common Name English
PYRIDINE, 2,2'-DITHIOBIS- 1,1'-DIOXIDE
Common Name English
OMDS
Code English
2,2'-DITHIODIPYRIDINE 1,1'-DIOXIDE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 88006
Created by admin on Mon Mar 31 17:45:10 GMT 2025 , Edited by admin on Mon Mar 31 17:45:10 GMT 2025
NCI_THESAURUS C28394
Created by admin on Mon Mar 31 17:45:10 GMT 2025 , Edited by admin on Mon Mar 31 17:45:10 GMT 2025
Code System Code Type Description
DRUG CENTRAL
4649
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PRIMARY
NSC
84740
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PRIMARY
DAILYMED
9L87N86R9A
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PRIMARY
FDA UNII
9L87N86R9A
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PRIMARY
DRUG BANK
DB11327
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PRIMARY
SMS_ID
100000082375
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PRIMARY
CAS
3696-28-4
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PRIMARY
ALANWOOD
dipyrithione
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PRIMARY
EPA CompTox
DTXSID1041897
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PRIMARY
ECHA (EC/EINECS)
223-024-5
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PRIMARY
NCI_THESAURUS
C80853
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PRIMARY
ChEMBL
CHEMBL549473
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PRIMARY
PUBCHEM
3109
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PRIMARY
NSC
241716
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PRIMARY
INN
3330
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PRIMARY
EVMPD
SUB07230MIG
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PRIMARY
MESH
C032196
Created by admin on Mon Mar 31 17:45:10 GMT 2025 , Edited by admin on Mon Mar 31 17:45:10 GMT 2025
PRIMARY
RXCUI
1362743
Created by admin on Mon Mar 31 17:45:10 GMT 2025 , Edited by admin on Mon Mar 31 17:45:10 GMT 2025
PRIMARY
Related Record Type Details
Structure of DIPYRITHIONE
ACTIVE MOIETY
NIH
NCATS
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