SUCRALOSE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H19Cl3O8
Molecular Weight	397.633
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl

InChI

InChIKey=BAQAVOSOZGMPRM-QBMZZYIRSA-N

InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C12H19Cl3O8
Molecular Weight	397.633
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/mesh/?term=Sucralose
Curator's Comment: Description was created using several sources including: http://www.theecologist.org/investigations/health/268764/life_after_aspartame.html#sthash.UsxH2vHn.dpuf; http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=172.831; http://www.sugar-and-sweetener-guide.com/e-number-index-for-sweeteners.html; https://www.ncbi.nlm.nih.gov/pubmed/14647086; https://clinicaltrials.gov/ct2/show/NCT02813759?term=SUCRALOSE&rank=3; http://www.kon.org/urc/frank.html; https://www.ncbi.nlm.nih.gov/pubmed/14647086

Sucralose (sold commercially as Splenda), a water-soluble chlorocarbohydrate, is a sweetener used to sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. In the European Union, it is also known under the E number E955. It is approved in USA by FDA under Chapter I-Food and Drug administration as a multipurpose additive permitted for direct addition to food for human consumption. Splenda is stated to be safe for use by subjects with type 2 diabetes since it does not effect glucose homeostasis in these patients. There is one ongoing clinical trial on effect and safety of sucralose in patients with type 2 diabetes in intensive insulin therapy.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Glucose Metabolism Disorders 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23668410 https://www.fda.gov/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/ucm397725.htm https://www.ncbi.nlm.nih.gov/pubmed/24219506	Preventing	Approved 8583	Splenda Approved Use Sucralose is approved for use in food as a non-nutritive sweetener. Launch Date 1997
Diarrhea 36 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f735ed98-79f5-41b8-867c-fc10b346cb00	Inactive ingredient	Approved 8583	SUEROLYTE ORAL ELECTROLYTE SOLUTION Approved Use Diarrhea Launch Date 2015
Gingivitis 45 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=63779942-0f6c-11c5-e053-2991aa0a25ab	Preventing	Approved 8583	CREST GUM DETOXIFY PLUS WHITENING Approved Use aids in the prevention of cavities helps prevent gingivitis helps interfere with the harmful effects of plaque associated with gingivitis helps control plaque bacteria that contribute to the development of gingivitis Launch Date 2017

PubMed

Title	Date	PubMed
Analysis of sucralose and other sweeteners in water and beverage samples by liquid chromatography/time-of-flight mass spectrometry.	2010-06-18	20304407
Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.	2010-05-14	20302879
Role of protein concentration and protein-saliva interactions in the astringency of whey proteins at low pH.	2010-05	20412903
Dysglycemias in pregnancy: from diagnosis to treatment. Brazilian consensus statement.	2010-04-24	20416099
Positive allosteric modulators of the human sweet taste receptor enhance sweet taste.	2010-03-09	20173092
Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults.	2010-03	20081547
Inadequate toxicity tests of food additive acesulfame.	2010-02-20	20166324
The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance.	2010-02-15	20156347
Standards of medical care in diabetes--2010.	2010-01	20042772
Development of taste masked fast disintegrating films of levocetirizine dihydrochloride for oral use.	2010-01	19863484
Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review.	2010	20339492
Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion.	2009-12	19808921
Colonic permeability is higher in Great Danes compared with smaller breed-dogs.	2009-12	18700845
Physicochemical Characterization, in vitro Release and Permeation Studies of Respirable Rifampicin-Cyclodextrin Inclusion Complexes.	2009-11	20376216
The study on long-term toxicity of d-psicose in rats.	2009-11	19902016
Double-blind, placebo-controlled trial of reformulated azelastine nasal spray in patients with seasonal allergic rhinitis.	2009-10-08	19807985
Expert panel report on a study of Splenda in male rats.	2009-10	19567260
An overview of the safety of sucralose.	2009-10	19464334
Development and formulation of a 0.2% oral solution of midazolam containing gamma-cyclodextrin.	2009-09-11	19467307
Determination of sucralose in soft drinks by high-performance thin-layer chromatography: interlaboratory study.	2009-09-01	19714984
A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy.	2009-09	19491826
Determination of complex polysaccharides by HPAE-PAD in foods: validation using accuracy profile.	2009-08-01	18952505
Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).	2009-07	19533103
Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells.	2009-07	19208342
[Sweetened solution intake in albino rats: taste versus calories].	2009-05	19403070
Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia.	2009-05	19223595
Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study.	2009-04-23	19382579
Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.	2009-04-22	19275236
Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora.	2009-04-16	19366814
Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects.	2009-04	19221011
Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA).	2009-04	19151203
Acidogenic potential of "sugar-free" cough drops.	2009-03-06	19444340
Preparation and evaluation of soft gellan gum gel containing paracetamol.	2009-03	20336205
Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intake.	2009-03	19129238
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.	2009-03	19106249
Sucralose screening in European surface waters using a solid-phase extraction-liquid chromatography-triple quadrupole mass spectrometry method.	2009-02-13	19131070
Clinical relevance of measuring colonic permeability.	2009-02	19200167
Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells.	2009-02	19082577
An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine.	2009-01-15	19001049
Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis.	2009-01	19220164
Standards of medical care in diabetes--2009.	2009-01	19118286
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse.	2009-01	18829978
Sweet taste signaling functions as a hypothalamic glucose sensor.	2009	19587847
Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion.	2009	19352508
Glucose sensing in L cells: a primary cell study.	2008-12	19041768
Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome.	2008-10-15	18671775
Effects of mouth rinses on color stability of resin composites.	2008-10	19212530
Xylitol gummy bear snacks: a school-based randomized clinical trial.	2008-07-25	18657266
Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats.	2008	18800291
The erosive potential of some flavoured waters.	2007-01	19212489

Patents

Sample Use Guides

In Vivo Use Guide

Expected human daily intake is at a level of 1.1 mg/kg/day. individuals with type 2 diabetes.

Route of Administration: Oral

In Vitro Use Guide

To map of the sweet taste enhancer interaction site in sweet–umami chimeric receptors hT1R2-1/hT1R3 and hT1R1-2/rT1R3 stable cell lines were assayed by using fluorescence imaging plate reader (FLIPR). Dose-dependent response curves of hT1R2-1/hT1R3 stable cell line were determined in the absence and presence of SE-2 at sucralose increasing concentration up to 10 mM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:05 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:05 GMT 2025`
Record UNII	96K6UQ3ZD4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SUCRALOSE

Official Name

English

SPLENDA

Preferred Name

English

SAN SWEET SA 8020

Common Name

English

TGS

Common Name

English

ASPASVIT

Common Name

English

4,1',6'-TRICHLOROGALACTOSUCROSE

Common Name

English

SUCRALOSE [FCC]

Common Name

English

1',4',6'-TRICHLORO-GALACTOSUCROSE

Common Name

English

INS NO.955

Code

English

SANSWEET SU 100

Common Name

English

SUCRAZIT

Common Name

English

SUCRALOSE [EP MONOGRAPH]

Common Name

English

INS-955

Code

English

NSC-759272

Code

English

SUCRALOSE [USP-RS]

Common Name

English

1,6-DICHLORO-1,6-DIDEOXY-.BETA.-D-FRUCTOFURANOSYL-4-CHLORO-4-DEOXY-.ALPHA.-D-GALACTOPYRANOSIDE

Common Name

English

Sucralose [WHO-DD]

Common Name

English

E-955

Code

English

TRICHLOROGALACTOSUCROSE

Common Name

English

SUCRALOSE [II]

Common Name

English

SUCRALOSE [MI]

Common Name

English

.ALPHA.-D-GALACTOPYRANOSIDE, 1,6-DICHLORO-1,6-DIDEOXY-.BETA.-D-FRUCTOFURANOSYL 4-CHLORO-4-DEOXY-

Common Name

English

SUCRALOSE [MART.]

Common Name

English

Classification Tree Code System Code

DSLD

1165 (Number of products:104)