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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H19Cl3O8
Molecular Weight 397.633
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SUCRALOSE

SMILES

OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl

InChI

InChIKey=BAQAVOSOZGMPRM-QBMZZYIRSA-N
InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1

HIDE SMILES / InChI

Description

Sucralose (sold commercially as Splenda), a water-soluble chlorocarbohydrate, is a sweetener used to sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. In the European Union, it is also known under the E number E955. It is approved in USA by FDA under Chapter I-Food and Drug administration as a multipurpose additive permitted for direct addition to food for human consumption. Splenda is stated to be safe for use by subjects with type 2 diabetes since it does not effect glucose homeostasis in these patients. There is one ongoing clinical trial on effect and safety of sucralose in patients with type 2 diabetes in intensive insulin therapy.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Splenda
Inactive ingredient
SUEROLYTE ORAL ELECTROLYTE SOLUTION
Preventing
CREST GUM DETOXIFY PLUS WHITENING

PubMed

Sample Use Guides

In Vivo Use Guide
Expected human daily intake is at a level of 1.1 mg/kg/day. individuals with type 2 diabetes.
Route of Administration: Oral
In Vitro Use Guide
To map of the sweet taste enhancer interaction site in sweet–umami chimeric receptors hT1R2-1/hT1R3 and hT1R1-2/rT1R3 stable cell lines were assayed by using fluorescence imaging plate reader (FLIPR). Dose-dependent response curves of hT1R2-1/hT1R3 stable cell line were determined in the absence and presence of SE-2 at sucralose increasing concentration up to 10 mM.