Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H19Cl3O8 |
| Molecular Weight | 397.633 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl
InChI
InChIKey=BAQAVOSOZGMPRM-QBMZZYIRSA-N
InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
DescriptionCurator's Comment: Description was created using several sources including: http://www.theecologist.org/investigations/health/268764/life_after_aspartame.html#sthash.UsxH2vHn.dpuf; http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=172.831; http://www.sugar-and-sweetener-guide.com/e-number-index-for-sweeteners.html; https://www.ncbi.nlm.nih.gov/pubmed/14647086; https://clinicaltrials.gov/ct2/show/NCT02813759?term=SUCRALOSE&rank=3; http://www.kon.org/urc/frank.html; https://www.ncbi.nlm.nih.gov/pubmed/14647086
Curator's Comment: Description was created using several sources including: http://www.theecologist.org/investigations/health/268764/life_after_aspartame.html#sthash.UsxH2vHn.dpuf; http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=172.831; http://www.sugar-and-sweetener-guide.com/e-number-index-for-sweeteners.html; https://www.ncbi.nlm.nih.gov/pubmed/14647086; https://clinicaltrials.gov/ct2/show/NCT02813759?term=SUCRALOSE&rank=3; http://www.kon.org/urc/frank.html; https://www.ncbi.nlm.nih.gov/pubmed/14647086
Sucralose (sold commercially as Splenda), a water-soluble chlorocarbohydrate, is a sweetener used to sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. In the European Union, it is also known under the E number E955. It is approved in USA by FDA under Chapter I-Food and Drug administration as a multipurpose additive permitted for direct addition to food for human consumption. Splenda is stated to be safe for use by subjects with type 2 diabetes since it does not effect glucose homeostasis in these patients. There is one ongoing clinical trial on effect and safety of sucralose in patients with type 2 diabetes in intensive insulin therapy.
Originator
Curator's Comment: Sucralose was discovered in 1976 by researchers at British sugar refiner Tate & Lyle. Four years later, Tate & Lyle joined forces with Johnson & Johnson to develop and commercialize sucralose under the auspices of a new company, McNeil Specialty Products (now called McNeil Nutritionals)
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Splenda Approved UseSucralose is approved for use in food as a non-nutritive sweetener. Launch Date1997 |
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| Inactive ingredient | SUEROLYTE ORAL ELECTROLYTE SOLUTION Approved UseDiarrhea Launch Date2015 |
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| Preventing | CREST GUM DETOXIFY PLUS WHITENING Approved Useaids in the prevention of cavities
helps prevent gingivitis
helps interfere with the harmful effects of plaque associated with gingivitis
helps control plaque bacteria that contribute to the development of gingivitis Launch Date2017 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Determination of sucralose in foods by HPLC]. | 2001 Apr |
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| [Determination of sucralose in foods by anion-exchange chromatography and reverse-phase chromatography]. | 2001 Apr |
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| Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs. | 2001 Nov |
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| Sweetener preference of C57BL/6ByJ and 129P3/J mice. | 2001 Sep |
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| The comet assay with 8 mouse organs: results with 39 currently used food additives. | 2002 Aug 26 |
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| Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeability. | 2003 Jan 25 |
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| Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography. | 2003 Jan-Feb |
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| Female rats show a bimodal preference response to the artificial sweetener sucralose. | 2004 Jul |
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| Oral zinc sulfate solutions inhibit sweet taste perception. | 2004 Jul |
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| Determination of sucralose in Splenda and a sugar-free beverage using high-performance anion-exchange chromatography with pulsed amperometric detection. | 2004 Jul 14 |
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| Evaluation of a triple sugar test of colonic permeability in humans. | 2004 Oct |
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| Artificial sweeteners--do they bear a carcinogenic risk? | 2004 Oct |
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| [Analysis of nine kinds of sweeteners in foods by LC/MS]. | 2005 Jun |
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| A simple method for the analysis of urinary sucralose for use in tests of intestinal permeability. | 2005 May |
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| Testing needed for acesulfame potassium, an artificial sweetener. | 2006 Sep |
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| The erosive potential of some flavoured waters. | 2007 Jan |
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| Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. | 2007 Jul 1 |
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| Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation. | 2007 Jul 20 |
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| Altered intestinal function in patients with chronic heart failure. | 2007 Oct 16 |
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| Behavioral genetics and taste. | 2007 Sep 18 |
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| Analysis and stability of sucralose in a milk-based confection by a simple planar chromatographic method. | 2007 Sep 5 |
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| Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacity. | 2007 Sep-Oct |
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| Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. | 2008 Aug |
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| Glucose sensing in L cells: a primary cell study. | 2008 Dec |
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| Sucrose activates human taste pathways differently from artificial sweetener. | 2008 Feb 15 |
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| Sucralose and migraine. | 2008 Jan |
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| Xylitol gummy bear snacks: a school-based randomized clinical trial. | 2008 Jul 25 |
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| Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome. | 2008 Oct 15 |
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| Specific interactions between diphenhydramine and alpha-helical poly(glutamic acid)--a new ion-pairing complex for taste masking and pH-controlled diphenhydramine release. | 2008 Sep |
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| Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. | 2009 Apr |
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| Colonic permeability is higher in Great Danes compared with smaller breed-dogs. | 2009 Dec |
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| Clinical relevance of measuring colonic permeability. | 2009 Feb |
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| Standards of medical care in diabetes--2009. | 2009 Jan |
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| Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study. | 2009 Jan-Feb |
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| Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). | 2009 Jul |
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| Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. | 2009 Mar |
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| Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. | 2010 Mar 9 |
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| Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. | 2010 May 14 |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.kon.org/urc/frank.html
Expected human daily intake is at a level of 1.1 mg/kg/day. individuals with type 2 diabetes.
Route of Administration:
Oral
To map of the sweet taste enhancer interaction site in sweet–umami chimeric receptors hT1R2-1/hT1R3 and hT1R1-2/rT1R3 stable cell lines were assayed by using fluorescence imaging plate reader (FLIPR). Dose-dependent response curves of hT1R2-1/hT1R3 stable cell line were determined in the absence and presence of SE-2 at sucralose increasing concentration up to 10 mM.
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DSLD |
1165 (Number of products:104)
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JECFA EVALUATION |
INS-955
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CODEX ALIMENTARIUS (GSFA) |
INS-955
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CFR |
21 CFR 172.831
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NCI_THESAURUS |
C283
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7964
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CHEMBL2107529
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259-952-2
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Sucralose
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C79882
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1623626
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1439115
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71485
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SUCRALOSE
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DTXSID1040245
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759272
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56038-13-2
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m10281
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96K6UQ3ZD4
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100000078319
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96K6UQ3ZD4
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SUB20056
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ACTIVE MOIETY
