EMBUTRAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H27NO3
Molecular Weight	293.4012
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(CC)(CNC(=O)CCCO)C1=CC=CC(OC)=C1

InChI

InChIKey=LMBMDLOSPKIWAP-UHFFFAOYSA-N

InChI=1S/C17H27NO3/c1-4-17(5-2,13-18-16(20)10-7-11-19)14-8-6-9-15(12-14)21-3/h6,8-9,12,19H,4-5,7,10-11,13H2,1-3H3,(H,18,20)

HIDE SMILES / InChI

Molecular Formula	C17H27NO3
Molecular Weight	293.4012
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm051493.pdf
Curator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/27404634

Embutramide is a veterinary, CNS active medicine used for euthanasia in dogs. The drug is marketed under the name Tributame in the USA and under the name Tanax in Europe. Human consumption of the drug is usually associated with suicide attempts.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Euthanasia 3 Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm051493.pdf	Palliative		Approved 8583	TRIBUTAME Approved Use TRIBUTAME Euthanasia Solution is indicated for euthanasia in dogs only. Launch Date 2005

PubMed

Title	Date	PubMed
Dimethylformamide metabolism following self-harm using a veterinary euthanasia product.	2010-08	20849330
Dorsal arthrodesis in prepubertal New Zealand white rabbits followed to skeletal maturity: Effect on thoracic dimensions, spine growth and neural elements.	2010-01	20165672
Different solutions used for submucosal injection influenced early healing of gastric endoscopic mucosal resection in a preclinical study in experimental pigs.	2009-09	19057952
Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model.	2009-03	19168856
Experimental infection with a low virulence isolate of Neospora caninum at 70 days gestation in cattle did not result in foetopathy.	2009-02-27	19497257
Development of a liquid chromatography-tandem mass spectrometry method for an euthanasic veterinarian drug: Tanax.	2008-11-04	18818042
Effects of electromagnetic fields of low frequency and low intensity on rat metabolism.	2008-04-01	18380892
DEA lists embutramide as schedule III controlled substance.	2006-11-01	17139797
A novel LC-ESI-MS-MS method for sensitive quantification of colchicine in human plasma: application to two case reports.	2006-04	16803656
A rapid and sensitive high-performance liquid chromatography method for determination of embutramide (a Tanax or T61 component) in human blood with photodiode-array UV detection.	2004-03	15068565
Blood investigation in a fatality involving the veterinary drug T-61.	2002-10	12423012
Comparison of HPLC and GC-MS methods for determination of embutramide (a component of Tanax or T-61) in biological specimens.	2001-08-14	11499885

Patents

Sample Use Guides

In Vivo Use Guide

Inject 1 mL of embutramide (in the form of TRIBUTAME Euthanasia Solution) for each 5 pounds body weight (0.45 mL/kg). Administer the calculated dose as a single intravenous bolus injection within a 10- to 15 second period.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:13:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:13:58 GMT 2025`
Record UNII	3P4TQG94T1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EMBUTRAMID

Preferred Name

English

EMBUTRAMIDE

Official Name

English

N-(.BETA.,.BETA.-DIETHYL-M-METHOXYPHENETHYL)-4-HYDROXYBUTYRAMIDE

Systematic Name

English

embutramide [INN]

Common Name

English

EMBUTRAMIDE [USAN]

Common Name

English

EMBUTRAMID [GREEN BOOK]

Common Name

English

HOE-18-680

Code

English

T-61

Code

English

EMBUTRAMIDE [MART.]

Common Name

English

HOE-18680

Code

English

EMBUTANE

Code

English

BUTANAMIDE, N-(2-ETHYL-2-(3-METHOXYPHENYL)BUTYL)-4-HYDROXY-

Systematic Name

English

HOE 18 680

Code

English

Classification Tree Code System Code

DEA NO.

2020