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Details

Stereochemistry ACHIRAL
Molecular Formula C9H10ClN5O2
Molecular Weight 255.661
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMIDACLOPRID

SMILES

[O-][N+](=O)NC1=NCCN1CC2=CC=C(Cl)N=C2

InChI

InChIKey=YWTYJOPNNQFBPC-UHFFFAOYSA-N
InChI=1S/C9H10ClN5O2/c10-8-2-1-7(5-12-8)6-14-4-3-11-9(14)13-15(16)17/h1-2,5H,3-4,6H2,(H,11,13)

HIDE SMILES / InChI

Description

Imidacloprid is a systemic, chloro-nicotinyl insecticide used for the control of sucking insects such as fleas, aphids, whiteflies, termites, turf insects, soil insects, and some beetles. It is used on co on and vegetable crops as foliar and seed treatments, soil, structures, indoor and outdoor insect control, home gardening and pet products. It is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. It kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). It is also indicated for the treatment and control of the following intestinal parasites Hookworm species, Roundworm species, Whipworms. Adverse events in animals included: malaise, vomiting, diarrhea, shaking, mydriasis, hypersalivation with abnormal neurologic signs, seizures, death, generalized hematoma of the body, and alopecia at the treatment site. Adverse reactions in humans included: burning, tingling, numbness, bad taste in the mouth, dizziness, and headache.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
5.14 null [pIC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Advantage® DUO
Curative
Advantage® DUO
Curative
Advantage® DUO
Curative
Advantage® DUO
Curative
Advantage® DUO
Curative
Advantage® DUO
Curative
Advantage® DUO

PubMed

Sample Use Guides

In Vivo Use Guide
The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month.
Route of Administration: Topical
In Vitro Use Guide
The highest sister chromatid exchange (SCE) per cell in rabbit peripheral blood lymphocytes was observed after exposure to 0.6 mg/L of Imidacloprid - 8.69±3.17 SCE per cell.