Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H9BrFN3 |
Molecular Weight | 258.0901 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
c1cc(c(c(c1)F)NC2=NCCN2)Br
InChI
InChIKey=KDPNLRQZHDJRFU-UHFFFAOYSA-N
InChI=1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
Molecular Formula | C9H9BrFN3 |
Molecular Weight | 258.0901 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: O77721 Gene ID: NA Gene Symbol: ADRA2B Target Organism: Equus caballus (Horse) |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | SEDIVET Approved UseFor use as a sedative and analgesic to facilitate handling, clinical examinations, clinical procedures, and minor surgical procedures in adult horses; and for use as a preanesthetic prior to the induction of general anesthesia in adult horses. Launch Date1.0862208E12 |
PubMed
Title | Date | PubMed |
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Romifidine-ketamine anaesthesia in atropine and triflupromazine pre-medicated buffalo calves. | 2004 Dec |
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Effects of tiletamine/zolazepam-romifidine-atropine in ocelots (Leopardus pardalis). | 2004 Jul |
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Sedative, analgesic and cardiorespiratory effects of romifidine in cats. | 2004 Jul |
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A romifidine and morphine combination for epidural analgesia of the flank in cattle. | 2004 Nov |
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Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. | 2004 Oct |
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Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. | 2005 Jan |
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Standing oral extraction of cheek teeth in 100 horses (1998--2003). | 2005 Mar |
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Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses. | 2005 Mar |
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Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. | 2005 Nov |
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High inspired oxygen concentrations increase intrapulmonary shunt in anaesthetized horses. | 2005 Nov |
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Romifidine or medetomidine premedication before propofol-sevoflurane anaesthesia in dogs. | 2005 Oct |
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Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis. | 2005 Oct |
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Dissociative anaesthesia during field and hospital conditions for castration of colts. | 2006 |
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Heart rate responses during acclimation of horses to water treadmill exercise. | 2006 Aug |
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Risk factors for colic in horses after general anaesthesia for MRI or nonabdominal surgery: absence of evidence of effect from perianaesthetic morphine. | 2006 Jul |
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Effect of intratesticular injection of lidocaine on cardiovascular responses to castration in isoflurane-anesthetized stallions. | 2006 Mar |
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A2-agonists in sheep: a review. | 2006 Mar |
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[Alpha-2-agonists: everyday anesthetic treatment in veterinary medicine, but far from safe. The consequences of accidental self injection]. | 2006 Mar 15 |
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Comparison of romifidine and medetomidine pre-medication in propofol-isoflurane anaesthetised dogs. | 2006 Nov |
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Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol. | 2006 Oct |
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The use of alpha-2 agonists in the equine practice: comparison between three molecules. | 2007 Aug |
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Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. | 2007 Feb |
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The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses. | 2007 Jan |
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Bilateral Polydactyly in a foal. | 2007 Jun |
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Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles). | 2007 Nov |
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Metabolism before, during and after anaesthesia in colic and healthy horses. | 2007 Nov 15 |
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Anaesthesia of pigs with a combination of romifidine, butorphanol and ketamine. | 2008 Dec 13 |
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Sparing effect of a low dose of intrathecal morphine on fentanyl requirements during spinal surgery: a preliminary clinical investigation in dogs. | 2008 Feb |
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Epithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction. | 2008 Feb 23 |
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Comparison of ketamine and S(+)-ketamine, with romifidine and diazepam, for total intravenous anesthesia in horses. | 2008 Jan |
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Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. | 2008 Jan 19 |
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Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies. | 2008 Jul |
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Clinical evaluation of ketamine and lidocaine intravenous infusions to reduce isoflurane requirements in horses under general anaesthesia. | 2008 Jul |
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A comparison of recovery times and characteristics with sevoflurane and isoflurane anaesthesia in horses undergoing magnetic resonance imaging. | 2008 Sep |
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The influence of body mass and thoracic dimensions on arterial oxygenation in anaesthetized horses and ponies. | 2008 Sep |
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Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane. | 2009 Dec |
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Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses. | 2009 Jul |
|
Sedative and analgesic effects of romifidine in camels (Camelus dromedarius). | 2009 Jul |
|
Anaesthetic and cardiorespiratory effects of romifidine/ketamine combinations in cats. | 2009 Jul |
|
Castration of horses under total intravenous anaesthesia: analgesic effects of lidocaine. | 2009 Mar |
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Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies. | 2009 Mar |
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Alterations in the glutathione metabolism could be implicated in the ischemia-induced small intestinal cell damage in horses. | 2009 Mar 18 |
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Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. | 2009 May |
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Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse. | 2009 May 7 |
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Alfaxalone in cyclodextrin for induction and maintenance of anaesthesia in ponies undergoing field castration. | 2009 Sep |
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Human exposures to immobilising agents: results of an online survey. | 2010 Aug 28 |
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Alpha-2 agonists as pain therapy in horses. | 2010 Dec |
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Cardiovascular effects following epidural injection of romifidine in isoflurane-anaesthetized dogs. | 2010 Mar |
|
Effects of adding butorphanol to a balanced anaesthesia protocol during arthroscopic surgery in horses. | 2010 Mar 13 |
|
Romifidine as a constant rate infusion in isoflurane anaesthetized horses: a clinical study. | 2010 Sep |
Patents
Sample Use Guides
Sedative doses ranged between 30 and 100 mcg/kg; preanesthetic doses ranged between 40 and 100 mcg/kg.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9647475
Rat spinal cord preparations were treated with romifidine at concentrations from 1 to 1000 nM. The drug depressed both the high intensity and low intensity excitatory postsynaptic potential with EC50 value of 23.4 nM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 09:50:52 UTC 2021
by
admin
on
Sat Jun 26 09:50:52 UTC 2021
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Record UNII |
876351L05K
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Record Status |
Validated (UNII)
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Record Version |
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-
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CFR |
21 CFR 522.2076
Created by
admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
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NCI_THESAURUS |
C47794
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admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
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WHO-VATC |
QN05CM93
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65896-16-4
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876351L05K
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65896-16-4
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C076257
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1091919
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ROMIFIDINE
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M11985
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71969
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6148
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C74389
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CHEMBL2105424
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SUB10374MIG
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DB11543
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Related Record | Type | Details | ||
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TARGET -> AGONIST |
SHORT-ACTING
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |