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Details

Stereochemistry ACHIRAL
Molecular Formula C9H9BrFN3
Molecular Weight 258.0901
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ROMIFIDINE

SMILES

c1cc(c(c(c1)F)NC2=NCCN2)Br

InChI

InChIKey=KDPNLRQZHDJRFU-UHFFFAOYSA-N
InChI=1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)

HIDE SMILES / InChI

Molecular Formula C9H9BrFN3
Molecular Weight 258.0901
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Romifidine is an alpha2-adrenergic agonist, which as a sedative and analgesic in horses. The drug was approved by FDA under the name Sedivet. It has no use in humans.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: O77721
Gene ID: NA
Gene Symbol: ADRA2B
Target Organism: Equus caballus (Horse)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SEDIVET

Approved Use

For use as a sedative and analgesic to facilitate handling, clinical examinations, clinical procedures, and minor surgical procedures in adult horses; and for use as a preanesthetic prior to the induction of general anesthesia in adult horses.

Launch Date

1.0862208E12
PubMed

PubMed

TitleDatePubMed
Romifidine-ketamine anaesthesia in atropine and triflupromazine pre-medicated buffalo calves.
2004 Dec
Effects of tiletamine/zolazepam-romifidine-atropine in ocelots (Leopardus pardalis).
2004 Jul
Sedative, analgesic and cardiorespiratory effects of romifidine in cats.
2004 Jul
A romifidine and morphine combination for epidural analgesia of the flank in cattle.
2004 Nov
Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse.
2004 Oct
Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies.
2005 Jan
Standing oral extraction of cheek teeth in 100 horses (1998--2003).
2005 Mar
Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses.
2005 Mar
Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses.
2005 Nov
High inspired oxygen concentrations increase intrapulmonary shunt in anaesthetized horses.
2005 Nov
Romifidine or medetomidine premedication before propofol-sevoflurane anaesthesia in dogs.
2005 Oct
Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis.
2005 Oct
Dissociative anaesthesia during field and hospital conditions for castration of colts.
2006
Heart rate responses during acclimation of horses to water treadmill exercise.
2006 Aug
Risk factors for colic in horses after general anaesthesia for MRI or nonabdominal surgery: absence of evidence of effect from perianaesthetic morphine.
2006 Jul
Effect of intratesticular injection of lidocaine on cardiovascular responses to castration in isoflurane-anesthetized stallions.
2006 Mar
A2-agonists in sheep: a review.
2006 Mar
[Alpha-2-agonists: everyday anesthetic treatment in veterinary medicine, but far from safe. The consequences of accidental self injection].
2006 Mar 15
Comparison of romifidine and medetomidine pre-medication in propofol-isoflurane anaesthetised dogs.
2006 Nov
Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol.
2006 Oct
The use of alpha-2 agonists in the equine practice: comparison between three molecules.
2007 Aug
Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine.
2007 Feb
The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses.
2007 Jan
Bilateral Polydactyly in a foal.
2007 Jun
Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles).
2007 Nov
Metabolism before, during and after anaesthesia in colic and healthy horses.
2007 Nov 15
Anaesthesia of pigs with a combination of romifidine, butorphanol and ketamine.
2008 Dec 13
Sparing effect of a low dose of intrathecal morphine on fentanyl requirements during spinal surgery: a preliminary clinical investigation in dogs.
2008 Feb
Epithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction.
2008 Feb 23
Comparison of ketamine and S(+)-ketamine, with romifidine and diazepam, for total intravenous anesthesia in horses.
2008 Jan
Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats.
2008 Jan 19
Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies.
2008 Jul
Clinical evaluation of ketamine and lidocaine intravenous infusions to reduce isoflurane requirements in horses under general anaesthesia.
2008 Jul
A comparison of recovery times and characteristics with sevoflurane and isoflurane anaesthesia in horses undergoing magnetic resonance imaging.
2008 Sep
The influence of body mass and thoracic dimensions on arterial oxygenation in anaesthetized horses and ponies.
2008 Sep
Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane.
2009 Dec
Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses.
2009 Jul
Sedative and analgesic effects of romifidine in camels (Camelus dromedarius).
2009 Jul
Anaesthetic and cardiorespiratory effects of romifidine/ketamine combinations in cats.
2009 Jul
Castration of horses under total intravenous anaesthesia: analgesic effects of lidocaine.
2009 Mar
Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies.
2009 Mar
Alterations in the glutathione metabolism could be implicated in the ischemia-induced small intestinal cell damage in horses.
2009 Mar 18
Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs.
2009 May
Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse.
2009 May 7
Alfaxalone in cyclodextrin for induction and maintenance of anaesthesia in ponies undergoing field castration.
2009 Sep
Human exposures to immobilising agents: results of an online survey.
2010 Aug 28
Alpha-2 agonists as pain therapy in horses.
2010 Dec
Cardiovascular effects following epidural injection of romifidine in isoflurane-anaesthetized dogs.
2010 Mar
Effects of adding butorphanol to a balanced anaesthesia protocol during arthroscopic surgery in horses.
2010 Mar 13
Romifidine as a constant rate infusion in isoflurane anaesthetized horses: a clinical study.
2010 Sep
Patents

Sample Use Guides

Sedative doses ranged between 30 and 100 mcg/kg; preanesthetic doses ranged between 40 and 100 mcg/kg.
Route of Administration: Intravenous
In Vitro Use Guide
Rat spinal cord preparations were treated with romifidine at concentrations from 1 to 1000 nM. The drug depressed both the high intensity and low intensity excitatory postsynaptic potential with EC50 value of 23.4 nM.
Substance Class Chemical
Created
by admin
on Sat Jun 26 09:50:52 UTC 2021
Edited
by admin
on Sat Jun 26 09:50:52 UTC 2021
Record UNII
876351L05K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ROMIFIDINE
INN   MART.  
INN  
Official Name English
SEDIVET
Brand Name English
ROMIFIDINE [MART.]
Common Name English
ROMIFIDINE [MI]
Common Name English
ROMIFIDINE [INN]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 522.2076
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
NCI_THESAURUS C47794
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
WHO-VATC QN05CM93
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
Code System Code Type Description
EPA CompTox
65896-16-4
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
FDA UNII
876351L05K
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
CAS
65896-16-4
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
MESH
C076257
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
RXCUI
1091919
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY RxNorm
WIKIPEDIA
ROMIFIDINE
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
MERCK INDEX
M11985
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
PUBCHEM
71969
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
INN
6148
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
NCI_THESAURUS
C74389
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
ChEMBL
CHEMBL2105424
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
EVMPD
SUB10374MIG
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
DRUG BANK
DB11543
Created by admin on Sat Jun 26 09:50:53 UTC 2021 , Edited by admin on Sat Jun 26 09:50:53 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY