U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 19:44:49 UTC 2023
Edited
by admin
on Thu Jul 06 19:44:49 UTC 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4R3XO922WS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NMDA RECEPTOR
Common Name English
N-methyl-D-aspartate receptor
Common Name English
NMDAR
Common Name English
Code System Code Type Description
FDA UNII
4R3XO922WS
Created by admin on Thu Jul 06 19:44:51 UTC 2023 , Edited by admin on Thu Jul 06 19:44:51 UTC 2023
PRIMARY
WIKIPEDIA
NMDA receptor antagonist
Created by admin on Thu Jul 06 19:44:51 UTC 2023 , Edited by admin on Thu Jul 06 19:44:51 UTC 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_43
N 1_185
N 1_221
N 1_258
N 1_282
N 1_332
N 1_350
N 1_422
N 1_453
N 1_473
N 1_753
N 2_43
N 2_185
N 2_221
N 2_258
N 2_282
N 2_332
N 2_350
N 2_422
N 2_453
N 2_473
N 2_753
N 3_53
N 3_318
N 3_358
N 3_421
N 3_519
N 3_592
N 3_665
N 3_864
N 3_881
N 3_889
N 3_924
N 3_967
N 3_1019
N 3_1116
N 3_1188
N 3_1375
N 4_48
N 4_315
N 4_322
N 4_418
N 4_465
N 4_516
N 4_589
N 4_662
N 4_866
N 4_884
N 4_889
N 4_1149
N 4_1174
N 4_1198
N 4_1249
N 4_1326
N 4_1424
N 4_1440
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Channel blocker
UNCOMPETITIVE
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Blocks glutamate binding.
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
Rat. Prodrug of dextrorphan, which is the actual mediator of most of its dissociative effects through acting as a more potent NMDA receptor antagonist than dextromethorphan itself.
Ki
INHIBITOR -> TARGET
Binds to glutamate site
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
MODULATOR->TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
MODULATOR->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
positive allosteric modulator of NMDA receptors
ALLOSTERIC
INHIBITOR -> TARGET
Competes with glutamate
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
Channel blocker
UNCOMPETITIVE
Ki
INHIBITOR -> TARGET
Noncompetitive antagonists at the NMDA receptor via binding to an allosteric site distinct from the glutamate-binding site.This receptor is a critical modulator of CNS neurotransmission, and excitability changes produced by ketamine antagonism may explain the drug’s anesthetic and analgesic properties.
ALLOSTERIC INHIBITOR
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
Active as an NMDA receptor antagonist in the central nervous system at roughly 30 times the potency of the "flagship" of its class, ketamine.
Ki
INHIBITOR -> TARGET
NON-COMPETITIVE
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL