Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H19N5O2 |
| Molecular Weight | 373.4079 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=N)C1=CC=C2C=C(OC(=O)C3=CC=C(NC4=NCCN4)C=C3)C=CC2=C1
InChI
InChIKey=QMRJOIUGPCVZPH-UHFFFAOYSA-N
InChI=1S/C21H19N5O2/c22-19(23)16-2-1-15-12-18(8-5-14(15)11-16)28-20(27)13-3-6-17(7-4-13)26-21-24-9-10-25-21/h1-8,11-12H,9-10H2,(H3,22,23)(H2,24,25,26)
| Molecular Formula | C21H19N5O2 |
| Molecular Weight | 373.4079 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sepimostat (also known as FUT-187) was developed as a serine protease inhibitor including Clr, Cls, kallikrein, trypsin, plasmin, and thrombin. Sepimostat participated in early phase II clinical study on patients with reflux esophagitis. As a result, sepimostat could be used for postgastrectomy reflux esophagitis at the dose level of 300 mg/day or less. Experiments on rodents have shown that the drug could be also useful in the therapy of alcohol-induced pancreatitis. However, all these studies were discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo. | 1990 Jan |
|
| [Early phase II study of FUT-187 (sepimostat mesilate) on reflux esophagitis--mainly on postgastrectomy reflux esophagitis]. | 1994 May |
| Substance Class |
Chemical
Created
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admin
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Edited
Fri Dec 15 16:28:20 UTC 2023
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| Record UNII |
5ZFR16F4QQ
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C783
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108041
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CHEMBL114586
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DTXSID50146144
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100000084113
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m925
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PRIMARY | Merck Index |
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
