Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H8F7NO3 |
| Molecular Weight | 383.2177 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC(NCC2=C(F)C(F)=C(C(F)=C2F)C(F)(F)F)=CC=C1O
InChI
InChIKey=HABROHXUHNHQMY-UHFFFAOYSA-N
InChI=1S/C15H8F7NO3/c16-10-7(11(17)13(19)9(12(10)18)15(20,21)22)4-23-5-1-2-8(24)6(3-5)14(25)26/h1-3,23-24H,4H2,(H,25,26)
| Molecular Formula | C15H8F7NO3 |
| Molecular Weight | 383.2177 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons. | 2009 Jun |
|
| The functional and neuroprotective actions of Neu2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury. | 2010 Jan |
|
| Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke. | 2010 Nov |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:05:11 GMT 2023
by
admin
on
Sat Dec 16 09:05:11 GMT 2023
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| Record UNII |
TP6PKI8CQP
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| Record Status |
Validated (UNII)
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| Record Version |
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Common Name | English |
| Code System | Code | Type | Description | ||
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NEU-2000
Created by
admin on Sat Dec 16 09:05:12 GMT 2023 , Edited by admin on Sat Dec 16 09:05:12 GMT 2023
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PRIMARY | CAS Number: 640290-67-1; Synonyms: Neu-2000, Neu-2000-KL | ||
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300000010842
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C174917
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640290-67-1
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9951955
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TP6PKI8CQP
Created by
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10970
Created by
admin on Sat Dec 16 09:05:12 GMT 2023 , Edited by admin on Sat Dec 16 09:05:12 GMT 2023
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
Neu2000 is a dual-acting neuroprotective agent that functions both as a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist and a free radical scavenger. In the present study, we investigated the scavenging activity of Neu2000 on various classes of reactive oxygen species and reactive nitrogen species (ROS/RNS) as well as its efficacy for reducing free radicals and oxidative stress/damage induced in spinal cord mitochondrial preparations. Neu2000 exerted scavenging activity against superoxide, nitric oxide, and hydroxyl radicals, and efficiently scavenged peroxynitrite. In the mitochondrial studies, Neu2000 markedly inhibited ROS/RNS and hydrogen peroxide levels following antimycin treatment. The results of the present study demonstrate that Neu2000 possesses potent in vitro antioxidant activity due, most likely, to its active phenoxy group.
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