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Details

Stereochemistry ACHIRAL
Molecular Formula C15H8F7NO3
Molecular Weight 383.2177
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NELONEMDAZ

SMILES

OC(=O)C1=CC(NCC2=C(F)C(F)=C(C(F)=C2F)C(F)(F)F)=CC=C1O

InChI

InChIKey=HABROHXUHNHQMY-UHFFFAOYSA-N
InChI=1S/C15H8F7NO3/c16-10-7(11(17)13(19)9(12(10)18)15(20,21)22)4-23-5-1-2-8(24)6(3-5)14(25)26/h1-3,23-24H,4H2,(H,25,26)

HIDE SMILES / InChI

Molecular Formula C15H8F7NO3
Molecular Weight 383.2177
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
The functional and neuroprotective actions of Neu2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury.
2010 Jan
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:05:11 UTC 2023
Edited
by admin
on Sat Dec 16 09:05:11 UTC 2023
Record UNII
TP6PKI8CQP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NELONEMDAZ
INN  
Official Name English
NEU-2000
Code English
NEU-2000-KL
Code English
2-HYDROXY-5-((2,3,5,6-TETRAFLUORO-4-(TRIFLUOROMETHYL)PHENYL)METHYLAMINO)BENZOIC ACID
Systematic Name English
BENZOIC ACID, 2-HYDROXY-5-(((2,3,5,6-TETRAFLUORO-4-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO)-
Systematic Name English
nelonemdaz [INN]
Common Name English
Code System Code Type Description
MANUFACTURER PRODUCT INFORMATION
NEU-2000
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY CAS Number: 640290-67-1; Synonyms: Neu-2000, Neu-2000-KL
SMS_ID
300000010842
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY
NCI_THESAURUS
C174917
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY
CAS
640290-67-1
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY
PUBCHEM
9951955
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY
FDA UNII
TP6PKI8CQP
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY
INN
10970
Created by admin on Sat Dec 16 09:05:12 UTC 2023 , Edited by admin on Sat Dec 16 09:05:12 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Neu2000 is a dual-acting neuroprotective agent that functions both as a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist and a free radical scavenger. In the present study, we investigated the scavenging activity of Neu2000 on various classes of reactive oxygen species and reactive nitrogen species (ROS/RNS) as well as its efficacy for reducing free radicals and oxidative stress/damage induced in spinal cord mitochondrial preparations. Neu2000 exerted scavenging activity against superoxide, nitric oxide, and hydroxyl radicals, and efficiently scavenged peroxynitrite. In the mitochondrial studies, Neu2000 markedly inhibited ROS/RNS and hydrogen peroxide levels following antimycin treatment. The results of the present study demonstrate that Neu2000 possesses potent in vitro antioxidant activity due, most likely, to its active phenoxy group.