Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H8F7NO3 |
| Molecular Weight | 383.2177 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC(NCC2=C(F)C(F)=C(C(F)=C2F)C(F)(F)F)=CC=C1O
InChI
InChIKey=HABROHXUHNHQMY-UHFFFAOYSA-N
InChI=1S/C15H8F7NO3/c16-10-7(11(17)13(19)9(12(10)18)15(20,21)22)4-23-5-1-2-8(24)6(3-5)14(25)26/h1-3,23-24H,4H2,(H,25,26)
| Molecular Formula | C15H8F7NO3 |
| Molecular Weight | 383.2177 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:28:51 GMT 2025
by
admin
on
Mon Mar 31 22:28:51 GMT 2025
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| Record UNII |
TP6PKI8CQP
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Preferred Name | English | ||
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Official Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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NEU-2000
Created by
admin on Mon Mar 31 22:28:51 GMT 2025 , Edited by admin on Mon Mar 31 22:28:51 GMT 2025
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PRIMARY | CAS Number: 640290-67-1; Synonyms: Neu-2000, Neu-2000-KL | ||
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300000010842
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C174917
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640290-67-1
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9951955
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TP6PKI8CQP
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10970
Created by
admin on Mon Mar 31 22:28:51 GMT 2025 , Edited by admin on Mon Mar 31 22:28:51 GMT 2025
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
Neu2000 is a dual-acting neuroprotective agent that functions both as a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist and a free radical scavenger. In the present study, we investigated the scavenging activity of Neu2000 on various classes of reactive oxygen species and reactive nitrogen species (ROS/RNS) as well as its efficacy for reducing free radicals and oxidative stress/damage induced in spinal cord mitochondrial preparations. Neu2000 exerted scavenging activity against superoxide, nitric oxide, and hydroxyl radicals, and efficiently scavenged peroxynitrite. In the mitochondrial studies, Neu2000 markedly inhibited ROS/RNS and hydrogen peroxide levels following antimycin treatment. The results of the present study demonstrate that Neu2000 possesses potent in vitro antioxidant activity due, most likely, to its active phenoxy group.
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