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Restrict the search for
telotristat ethyl
to a specific field?
Status:
Investigational
Source:
INN:alphameprodine [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Alphameprodine (ACSCN 9604) is an opioid analgesic classified by the United States Drug Enforcement Administration under Schedule I of illegal substances. The stereoisomer betameprodine is similarly classified, however alphameprodine is more widely used (both are referred to as Meprodine). Alphameprodine is a structural analogue of meperidine. It exerts physiological effects characteristic of opioids, such as analgesia, euphoria and sedation, as well as itching, nausea, and respiratory depression.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dimenoxadol is an opioid analgesic which produces typical opioid effects such as analgesia and sedation. It is structurally similar to methadone and is a benzilic acid derivative. In the United States it is classified as a Schedule I controlled drug.
Status:
Investigational
Source:
NCT00430300: Phase 2 Interventional Terminated Pulmonary Disease, Chronic Obstructive
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
UK-432097 is a selective adenosine A2a agonist which was in development with Pfizer as an inhaled treatment for asthma and chronic obstructive pulmonary disease. UK-432097 had been in phase II clinical trials by Pfizer for the treatment of chronic obstructive pulmonary disease (COPD). However, this study was terminated prematurely due to futility based on results of interim analysis.
Class (Stereo):
CHEMICAL (RACEMIC)
Primidolol (also known as UK-11,443) is an imidazolidinone derivative patented by American pharmaceutical corporation Pfizer Corp as a specific β-adrenergic blocker. In clinical trials, Primidolol shows some antihypertensive activity but the overall change in the cardiovascular parameters failed to demonstrate a significant difference compared to placebo.
Status:
Investigational
Source:
Gastroenterology. Jan 2009;136(1):56-64; quiz 351-2.: Phase 3 Human clinical trial Completed Barrett Esophagus/pathology
Source URL:
Class (Stereo):
CHEMICAL (UNKNOWN)
Class (Stereo):
CHEMICAL (RACEMIC)
Class (Stereo):
CHEMICAL (MIXED)
Status:
Investigational
Source:
INN:dexetozoline [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Dexetozoline is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis.
Class (Stereo):
CHEMICAL (ACHIRAL)
Detanosal is antipyretic, analgesic and anti-inflammatory agent.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Icrocaptide, also known as ITF 1697, a chemically modified LYS-Pro tetrapeptide that was studied to reduce reperfusion injury. The ability of icrocaptide to inhibit the early functions of activated endothelial cells could be used as pharmacological tool in model of pathologies of a variety of microvascular disorders. In addition, tetrapeptide was involved in phase II clinical trials for patients undergoing percutaneous transluminal coronary angioplasty with or without coronary stenting. As a result, a trend toward reperfusion improvement was seen.
