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Details

Stereochemistry RACEMIC
Molecular Formula C17H23N3O4
Molecular Weight 333.3822
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PRIMIDOLOL

SMILES

CC1=CN(CCNCC(O)COC2=C(C)C=CC=C2)C(=O)NC1=O

InChI

InChIKey=RETPFDTUCPKFEC-UHFFFAOYSA-N
InChI=1S/C17H23N3O4/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23)

HIDE SMILES / InChI

Molecular Formula C17H23N3O4
Molecular Weight 333.3822
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Primidolol (also known as UK-11,443) is an imidazolidinone derivative patented by American pharmaceutical corporation Pfizer Corp as a specific β-adrenergic blocker. In clinical trials, Primidolol shows some antihypertensive activity but the overall change in the cardiovascular parameters failed to demonstrate a significant difference compared to placebo.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension.
1980
Immediate cardiovascular responses to oral prazosin--effects of concurrent beta-blockers.
1981 Mar
Patents

Patents

Sample Use Guides

50 mg or 100 mg daily, for a 4 days.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:34:10 GMT 2023
Edited
by admin
on Fri Dec 15 16:34:10 GMT 2023
Record UNII
56QH73D78K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PRIMIDOLOL
INN   USAN  
INN   USAN  
Official Name English
1-[2-[[2-Hydroxy-3-(O-tolyloxy)propyl]amino]ethyl]thymine
Systematic Name English
UK-11,443
Code English
PRIMIDOLOL [USAN]
Common Name English
UK-11443
Code English
primidolol [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29576
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
Code System Code Type Description
INN
4641
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
WIKIPEDIA
Primidolol
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
NCI_THESAURUS
C76557
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
CAS
67227-55-8
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
SMS_ID
100000081636
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
ChEMBL
CHEMBL1742460
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
EPA CompTox
DTXSID0043840
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
EVMPD
SUB10044MIG
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
PUBCHEM
68563
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
MESH
C025720
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
FDA UNII
56QH73D78K
Created by admin on Fri Dec 15 16:34:10 GMT 2023 , Edited by admin on Fri Dec 15 16:34:10 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY