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Details

Stereochemistry ABSOLUTE
Molecular Formula C40H47N11O6
Molecular Weight 777.8713
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of UK-432097

SMILES

CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=NC3=C2N=C(N=C3NCC(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)NCCNC(=O)NC6CCN(CC6)C7=NC=CC=C7

InChI

InChIKey=ZOTHAEBAWXWVID-HXEFRTELSA-N
InChI=1S/C40H47N11O6/c1-2-41-37(54)33-31(52)32(53)39(57-33)51-24-46-30-34(45-23-28(25-11-5-3-6-12-25)26-13-7-4-8-14-26)48-35(49-36(30)51)38(55)43-19-20-44-40(56)47-27-16-21-50(22-17-27)29-15-9-10-18-42-29/h3-15,18,24,27-28,31-33,39,52-53H,2,16-17,19-23H2,1H3,(H,41,54)(H,43,55)(H2,44,47,56)(H,45,48,49)/t31-,32+,33-,39+/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.pharmacodia.com/yaodu/html/v1/chemicals/127d2e587fe09591c67b04c7c7190479.html

UK-432097 is a selective adenosine A2a agonist which was in development with Pfizer as an inhaled treatment for asthma and chronic obstructive pulmonary disease. UK-432097 had been in phase II clinical trials by Pfizer for the treatment of chronic obstructive pulmonary disease (COPD). However, this study was terminated prematurely due to futility based on results of interim analysis.

Originator

Curator's Comment: # Pfizer

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.0 nM [IC50]
Conditions

Conditions

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
50 pg/mL
4500 μg single, respiratory
dose: 4500 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
UK-432097 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
1.6%
unknown, unknown
UK-432097 blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
1.4%
unknown, unknown
UK-432097 plasma
Rattus norvegicus
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as perpetrator​
PubMed

PubMed

TitleDatePubMed
Structure of an agonist-bound human A2A adenosine receptor.
2011 Apr 15
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: administered using an atomizer device
Formulated as a dry powder, supplied as capsules and administered using an atomizer device. Given as either 150mcg, 450mcg or 1350mcg BID.
Route of Administration: Intratracheal
UK-432097 (1uM) potently increased beta-cell proliferation in mouse islets in vitro
Name Type Language
UK-432097
Common Name English
.BETA.-D-RIBOFURANURONAMIDE, 1-DEOXY-1-(6-((2,2-DIPHENYLETHYL)AMINO)-2-(((2-((((1-(2-PYRIDINYL)-4-PIPERIDINYL)AMINO)CARBONYL)AMINO)ETHYL)AMINO)CARBONYL)-9H-PURIN-9-YL)-N-ETHYL-
Systematic Name English
UK-432,097
Code English
6-((2,2-DIPHENYLETHYL)AMINO)-9-(N-ETHYL-.BETA.-D-RIBOFURANOSYLURONAMIDE)-N-(2-(N'-(1-(2-PYRIDYL)-4-PIPERIDYL)UREIDO)ETHYL)-9H-PURINE-2-CARBOXAMIDE
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL1096896
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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FDA UNII
8L3OAJ1R5A
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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PUBCHEM
9833519
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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SMS_ID
300000041475
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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WIKIPEDIA
UK-432,097
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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EPA CompTox
DTXSID70431408
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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CAS
380221-63-6
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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DRUG BANK
DB12691
Created by admin on Fri Dec 15 16:34:22 GMT 2023 , Edited by admin on Fri Dec 15 16:34:22 GMT 2023
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