DEXETOZOLINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H20N2O3S
Molecular Weight	284.374
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)\C=C1/S[C@H](N2CCCCC2)C(=O)N1C

InChI

InChIKey=ZCKKHYXUQFTBIK-XPSMFNQNSA-N

InChI=1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9-/t13-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1766576 | https://www.ncbi.nlm.nih.gov/pubmed/1417365 | Greger, R.F., Knauf, H., Mutschler, E. (2012) Diuretics, page 256, retrieved from: https://books.google.ru/books?id=zhHpCAAAQBAJ

Dexetozoline is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis.

Approval Year

Sample Use Guides

In Vivo Use Guide

Mean daily dose 666 mg for 7 days

Route of Administration: Oral

Name

Type

Language

DEXETOZOLINE

Official Name

English

(+)-ETOZOLINE

Common Name

English

(+)-ETHYL (Z)-(S)-3-METHYL-4-OXO-5-PIPERIDINO-.DELTA.SUP(2,.ALPHA.)-THIAZOLIDINEACETATE

Common Name

English

ETOZOLINE, (S)-

Common Name

English

ETOZOLIN, (+)-

Common Name

English

ACETIC ACID, 2-((5S)-3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)-, ETHYL ESTER

Common Name

English

dexetozoline [INN]

Common Name

English

(+)-ETOZOLIN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270