U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C13H20N2O3S
Molecular Weight 284.374
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of DEXETOZOLINE

SMILES

CCOC(=O)\C=C1/S[C@H](N2CCCCC2)C(=O)N1C

InChI

InChIKey=ZCKKHYXUQFTBIK-XPSMFNQNSA-N
InChI=1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9-/t13-/m0/s1

HIDE SMILES / InChI

Molecular Formula C13H20N2O3S
Molecular Weight 284.374
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 1
Optical Activity UNSPECIFIED

Dexetozoline is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis.

Approval Year

Sample Use Guides

Mean daily dose 666 mg for 7 days
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:33:23 GMT 2023
Edited
by admin
on Fri Dec 15 16:33:23 GMT 2023
Record UNII
KK9WYJ6556
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DEXETOZOLINE
INN  
INN  
Official Name English
(+)-ETOZOLINE
Common Name English
(+)-ETHYL (Z)-(S)-3-METHYL-4-OXO-5-PIPERIDINO-.DELTA.SUP(2,.ALPHA.)-THIAZOLIDINEACETATE
Common Name English
ETOZOLINE, (S)-
Common Name English
ETOZOLIN, (+)-
Common Name English
ACETIC ACID, 2-((5S)-3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)-, ETHYL ESTER
Common Name English
dexetozoline [INN]
Common Name English
(+)-ETOZOLIN
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C270
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
Code System Code Type Description
CAS
77519-25-6
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
EPA CompTox
DTXSID601024609
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
INN
5093
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
EVMPD
SUB07027MIG
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
FDA UNII
KK9WYJ6556
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
PUBCHEM
637492
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106290
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
CAS
76333-71-6
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
SMS_ID
100000083222
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
NCI_THESAURUS
C78047
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
ECHA (EC/EINECS)
278-423-7
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
Related Record Type Details
ACTIVE MOIETY