PRIMIDOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H23N3O4
Molecular Weight	333.3822
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CN(CCNCC(O)COC2=C(C)C=CC=C2)C(=O)NC1=O

InChI

InChIKey=RETPFDTUCPKFEC-UHFFFAOYSA-N

InChI=1S/C17H23N3O4/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6104564 | https://www.ncbi.nlm.nih.gov/pubmed/6117955 | https://www.ncbi.nlm.nih.gov/pubmed/6110503

Primidolol (also known as UK-11,443) is an imidazolidinone derivative patented by American pharmaceutical corporation Pfizer Corp as a specific β-adrenergic blocker. In clinical trials, Primidolol shows some antihypertensive activity but the overall change in the cardiovascular parameters failed to demonstrate a significant difference compared to placebo.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension.	1980	6104564

Patents

Sample Use Guides

In Vivo Use Guide

50 mg or 100 mg daily, for a 4 days.

Route of Administration: Oral

Name

Type

Language

PRIMIDOLOL

Official Name

English

1-[2-[[2-Hydroxy-3-(O-tolyloxy)propyl]amino]ethyl]thymine

Systematic Name

English

UK-11,443

Code

English

PRIMIDOLOL [USAN]

Common Name

English

UK-11443

Code

English

primidolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576