U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C20H25NO3
Molecular Weight 327.4174
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMENOXADOL

SMILES

CCOC(C(=O)OCCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=RHUWRJWFHUKVED-UHFFFAOYSA-N
InChI=1S/C20H25NO3/c1-4-24-20(17-11-7-5-8-12-17,18-13-9-6-10-14-18)19(22)23-16-15-21(2)3/h5-14H,4,15-16H2,1-3H3

HIDE SMILES / InChI

Description

Dimenoxadol is an opioid analgesic which produces typical opioid effects such as analgesia and sedation. It is structurally similar to methadone and is a benzilic acid derivative. In the United States it is classified as a Schedule I controlled drug.

CNS Activity

CNS Active
4,002

Originator

Boehringer, A. et al.
1

Approval Year

Unknown
149,124

Targets

Primary TargetPharmacologyConditionPotency
Opioid receptors; mu/kappa/delta
33
Agonist
2,752

Conditions

ConditionModalityTargetsHighest PhaseProduct
Pain
619
 Palliative
Preclinical
Unknown

PubMed

Patents

JP2005530798A
42
JP4642467B2
32

Sample Use Guides

In Vivo Use Guide
LD50 i.v. in rats: 66 mg/kg
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
ACTIVE MOIETY
Structure of DIMENOXADOL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966