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Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
There is no much information related to the biological properties of ftaxilide. It is known, that it’s not intended for therapeutic use, but has the antibacterial properties and used as antiseptic.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Ftormetazine was studied as a psychotropic and an antiarrhythmic agent. Information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Panamesine (also known as EMD 57445) was studied as a sigma receptor ligand alleged to have antipsychotic effects. Panamesine reached phase II clinical trials for schizophrenia before the discontinuation of its development.
Status:
Investigational
Source:
NCT00759395: Phase 2 Interventional Completed Anxious Major Depressive Disorder
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (ACHIRAL)
Panidazole, an antiprotozoal agent that was studied in patients for the treatment of intestinal amoebiasis and vaginal trichomoniasis. However, information about the further development of this drug is not available.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Panuramine, a selective inhibitor of uptake of 5-hydroxytryptamine that was studied as an antidepressant, however, has never been marketed.
Class (Stereo):
CHEMICAL (ACHIRAL)
Panomifene (also known as GYKI-13504 or EGIS-5660), a triphenyl-alkene derivative that was studied as an antiestrogen. This drug binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. Panomifene reached phase II clinical trials for the treatment of breast cancer before development was terminated.
Class (Stereo):
CHEMICAL (ACHIRAL)
Papaveroline was developed in Italy. It was shown that this compound produced a dose-related inhibition of the aggregation of platelets. This compound is also studied in mental disorders caused by a deficit of non-focalized cerebral circulation. However, information about the further development of papaveroline is not available.
Class (Stereo):
CHEMICAL (RACEMIC)
Cromitrile is an antiallergic developed by Miles Laboratories Inc. The compound was also shown to possess bronchodilator and anti-inflammatory activity.
Status:
Investigational
Source:
Behav Pharmacol. Mar 2004;15(2):91-102.: Phase 1 Human clinical trial Completed Cocaine-Related Disorders
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Cyclazocine is a mixed opioid agonist/antagonist, an agonist of kappa opioid receptor, and a partial agonist of mu opioid receptor. The drug has analgesic activity and dose 0.25-0.5 mg/70 kg is equivalent to 10 mg/75 kg of morphine. Cyclazocine is a long-acting mu-opioid antagonist in human and was studied for the treatment of addiction to opioids and cocaine. Induction of the drug leads to dysphoria, hallucination, irritability, and sleeplessness.
