Details
| Stereochemistry | MIXED |
| Molecular Formula | C18H25NO |
| Molecular Weight | 271.3972 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1C2CC3=CC=C(O)C=C3C1(C)CCN2CC4CC4
InChI
InChIKey=YQYVFVRQLZMJKJ-UHFFFAOYSA-N
InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3
| Molecular Formula | C18H25NO |
| Molecular Weight | 271.3972 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Cyclazocine is a mixed opioid agonist/antagonist, an agonist of kappa opioid receptor, and a partial agonist of mu opioid receptor. The drug has analgesic activity and dose 0.25-0.5 mg/70 kg is equivalent to 10 mg/75 kg of morphine. Cyclazocine is a long-acting mu-opioid antagonist in human and was studied for the treatment of addiction to opioids and cocaine. Induction of the drug leads to dysphoria, hallucination, irritability, and sleeplessness.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Behavioural and electoencephalographic interactions between haloperidol and PCP/sigma ligands in the rat. | 1991 |
|
| Differential effects of fedotozine compared to other kappa agonists on diuresis in rats. | 1996 Dec |
|
| Effects of cyclazocine on cocaine self-administration in rats. | 1998 Sep 11 |
|
| Cyclazocine: comparison to hydromorphone and interaction with cocaine. | 2004 Mar |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:09:18 UTC 2023
by
admin
on
Fri Dec 15 16:09:18 UTC 2023
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| Record UNII |
J5W1B1159C
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C67413
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NCI_THESAURUS |
C681
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| Code System | Code | Type | Description | ||
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DTXSID9022863
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100000083727
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SUB06843MIG
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222-689-9
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19143
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Cyclazocine
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D003496
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3572-80-3
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1664
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m3968
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J5W1B1159C
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CHEMBL56585
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C80571
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107429
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ACTIVE MOIETY |
