PANOMIFENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H24F3NO2
Molecular Weight	427.4588
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCNCCOC1=CC=C(C=C1)C(=C(/C2=CC=CC=C2)C(F)(F)F)\C3=CC=CC=C3

InChI

InChIKey=MHXVDXXARZCVRK-WCWDXBQESA-N

InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+

HIDE SMILES / InChI

Molecular Formula	C25H24F3NO2
Molecular Weight	427.4588
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7519764 | https://www.ncbi.nlm.nih.gov/pubmed/9328614 | https://adisinsight.springer.com/drugs/800002425

Panomifene (also known as GYKI-13504 or EGIS-5660), a triphenyl-alkene derivative that was studied as an antiestrogen. This drug binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. Panomifene reached phase II clinical trials for the treatment of breast cancer before development was terminated.

Originator

Approval Year

PubMed

Title	Date	PubMed
A highly regio- and stereoselective carbocupration of fluoroalkylated internal alkynes: a short total synthesis of the antiestrogenic drug panomifene.	2004-03-18	15012068
Antiestrogens, antiandrogens.	1996	9328614
Determination of panomifene in human plasma by high-performance liquid chromatography.	1994-05-13	8032491
Influence of GYKI-13504, a new antioestrogen, on the responsiveness of isolated uterus removed from oestradiol pretreated rats to PGF2 alpha.	1985-12	3867510

Patents

Sample Use Guides

In Vivo Use Guide

12 mg and 120 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:20:29 GMT 2025` Edited by `admin` on `Mon Mar 31 18:20:29 GMT 2025`
Record UNII	GCW5E728OC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PANOMIFENE

Official Name

English

(E)-2-((2-(P-(3,3,3-TRIFLUORO-1,2-DIPHENYLPROPENYL)PHENOXY)ETHYL)AMINO)ETHANOL

Preferred Name

English

panomifene [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C481