Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H24F3NO2 |
| Molecular Weight | 427.4588 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCNCCOC1=CC=C(C=C1)C(=C(/C2=CC=CC=C2)C(F)(F)F)\C3=CC=CC=C3
InChI
InChIKey=MHXVDXXARZCVRK-WCWDXBQESA-N
InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+
| Molecular Formula | C25H24F3NO2 |
| Molecular Weight | 427.4588 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Panomifene (also known as GYKI-13504 or EGIS-5660), a triphenyl-alkene derivative that was studied as an antiestrogen. This drug binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. Panomifene reached phase II clinical trials for the treatment of breast cancer before development was terminated.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Influence of GYKI-13504, a new antioestrogen, on the responsiveness of isolated uterus removed from oestradiol pretreated rats to PGF2 alpha. | 1985 Dec |
|
| Determination of panomifene in human plasma by high-performance liquid chromatography. | 1994 May 13 |
|
| Antiestrogens, antiandrogens. | 1996 |
|
| A highly regio- and stereoselective carbocupration of fluoroalkylated internal alkynes: a short total synthesis of the antiestrogenic drug panomifene. | 2004 Mar 18 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:09:23 UTC 2023
by
admin
on
Fri Dec 15 16:09:23 UTC 2023
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| Record UNII |
GCW5E728OC
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C481
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C047993
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C66304
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GCW5E728OC
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SUB09606MIG
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Panomifene
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ACTIVE MOIETY |
