PANOMIFENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H24F3NO2
Molecular Weight	427.4588
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCNCCOC1=CC=C(C=C1)C(=C(/C2=CC=CC=C2)C(F)(F)F)\C3=CC=CC=C3

InChI

InChIKey=MHXVDXXARZCVRK-WCWDXBQESA-N

InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7519764 | https://www.ncbi.nlm.nih.gov/pubmed/9328614 | https://adisinsight.springer.com/drugs/800002425

Panomifene (also known as GYKI-13504 or EGIS-5660), a triphenyl-alkene derivative that was studied as an antiestrogen. This drug binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. Panomifene reached phase II clinical trials for the treatment of breast cancer before development was terminated.

Originator

Approval Year

PubMed

Title	Date	PubMed
Influence of GYKI-13504, a new antioestrogen, on the responsiveness of isolated uterus removed from oestradiol pretreated rats to PGF2 alpha.	1985 Dec	3867510
Determination of panomifene in human plasma by high-performance liquid chromatography.	1994 May 13	8032491
Antiestrogens, antiandrogens.	1996	9328614
A highly regio- and stereoselective carbocupration of fluoroalkylated internal alkynes: a short total synthesis of the antiestrogenic drug panomifene.	2004 Mar 18	15012068

Patents

Sample Use Guides

In Vivo Use Guide

12 mg and 120 mg

Route of Administration: Oral

Name

Type

Language

PANOMIFENE

Official Name

English

(E)-2-((2-(P-(3,3,3-TRIFLUORO-1,2-DIPHENYLPROPENYL)PHENOXY)ETHYL)AMINO)ETHANOL

Common Name

English

panomifene [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C481