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Search results for amphotericin root_codes_comments in Code Comments (approximate match)
Status:
Possibly Marketed Outside US
Source:
Atgard by Montrose Chemical
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dichlorvos is a synthetic organic chemical used as an insecticide. Dichlorvos does not occur naturally in the environment, but is manufactured by industry. Dichlorvos is sold under many trade names including Vapona®, Atgard®, Nuvan®, and Task®. It is also used as
an insecticide for slow release on pest-strips for pest control in homes. Dichlorvos is used as an
anthelmintic (worming agent) for dogs, swine, and horses, as a botacide (agent that kills fly larvae) for
horses, and in flea collars for dogs. In 1995, EPA proposed cancellation of dichlorvos for all home uses, and for many commercial and
industrial uses.
Status:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
17α-Hydroxyprogesterone (17α-OHP), or hydroxyprogesterone (OHP), also known as 17α-hydroxypregn-4-ene-3, 20-dione is used under the brand name Gestageno, and has been marketed for clinical use in Argentina. It was indicated for female infertility, hypertrichosis, menstrual disorders, premature labour, threatened or recurrent miscarriage. It is used to properly regulate the menstrual cycle and treat unusual stopping of the menstrual periods (amenorrhea). To help a pregnancy occur during egg donor or infertility procedures in women who do not produce enough progesterone. To prevent estrogen from thickening the lining of the uterus (endometrial hyperplasia) in women around menopause who are being treated with estrogen for ovarian hormone therapy (OHT). To treat a condition called endometriosis, to help prevent endometrial hyperplasia, or to treat unusual and heavy bleeding of the uterus (dysfunctional uterine bleeding) by starting or stopping the menstrual cycle. 17α-OHP is an agonist of the progesterone receptor (PR) similarly to progesterone. In addition, it is an antagonist of the mineralocorticoid receptor (MR) as well as a partial agonist of the glucocorticoid receptor (GR), albeit with very low potency (EC50 >100-fold less relative to cortisol) at the latter site, also similarly to progesterone.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Cycotiamine is a derivative of tiamine that was developed in Japan and used for the treatment of neurogenic bladder.
Status:
Possibly Marketed Outside US
Source:
Aldosterone
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Aldosterone is a hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. Recent findings have shown that the physiological functions of the hormone aldosterone go far beyond its well-known role in blood-pressure regulation and salt/water homeostasis. Aldosterone is for example involved in the regulation of inflammation, and also binds directly to mineralocorticoid receptors in specific brain regions. At the late distal tubule and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis leading to phosphorylation of the pump and a conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for Na+ ions, hence reabsorbing sodium (Na+) ions and water into the blood, and secreting potassium (K+) ions into the urine; 2) aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3−) levels and its acid/base balance; and 3) aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH) which serves to conserve water by direct actions on renal tubular resorption.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
NCT02075606: Phase 4 Human clinical trial Completed Neuroendocrine Tumors/pathology
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Fenprostalene is a long-acting PGF2 alpha analog. Fenprostalene is indicated for use in feedlot heifers to induce abortion when pregnant 150 days or less, for the induction of parturition in sows and gilts pregnant at least 112 days.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Apramycin is a broad-spectrum aminocyclitol antibiotic produced by a strain of Streptomyces tenebrarius. It has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans. Apramycin is registered for use in more than twenty countries in cattle, pigs and chickens. The drug exerts its antibacterial effect by inhibiting
protein synthesis at the level of peptidyl translocation. It is mostly used for treating gastrointestinal
infections. Apramycin is available in soluble powder and feed premix formulations.
Status:
Possibly Marketed Outside US
Source:
Producil by Merck
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Efrotomycin (ET) is an antibiotic obtained by the incubation of Nocardia lacamduranns, and
composed of 4 components: Efrotomycin A1, Efrotomycin A2, Efrotomycin B1, and Efrotomycin B2. Although its antibacterial spectrum is narrow, ET has an antibacterial effect on part of the Grampositive
bacteria and on treponema, and has a growth promoting effect on pigs etc. ET is a pure-grade antibiotic that was designated as a feed additive. Under the brand name Producil Efrotomycin was indicated for increased rate of weight gain when incorporated into complete swine feeds at 3.6 to 14.5 g/ton. This antibiotic is a potent inhibitor of bacterial protein synthesis by interfering
with peptide transfer reactions associated with the elongation factor Tu.