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Details

Stereochemistry ACHIRAL
Molecular Formula C4H7Cl2O4P
Molecular Weight 220.976
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICHLORVOS

SMILES

COP(=O)(OC)OC=C(Cl)Cl

InChI

InChIKey=OEBRKCOSUFCWJD-UHFFFAOYSA-N
InChI=1S/C4H7Cl2O4P/c1-8-11(7,9-2)10-3-4(5)6/h3H,1-2H3

HIDE SMILES / InChI

Description

Dichlorvos is a synthetic organic chemical used as an insecticide. Dichlorvos does not occur naturally in the environment, but is manufactured by industry. Dichlorvos is sold under many trade names including Vapona®, Atgard®, Nuvan®, and Task®. It is also used as an insecticide for slow release on pest-strips for pest control in homes.  Dichlorvos is used as an anthelmintic (worming agent) for dogs, swine, and horses, as a botacide (agent that kills fly larvae) for horses, and in flea collars for dogs. In 1995, EPA proposed cancellation of dichlorvos for all home uses, and for many commercial and industrial uses.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
269.0 nM [IC50]
230.0 nM [IC50]
44.0 nM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Atgard

PubMed

Sample Use Guides

In Vivo Use Guide
Rats received orally 2.5, 5 and 10mg/kg body weight of Dichlorvos (DDVP) respectively for 28 days.
Route of Administration: Oral
In Vitro Use Guide
Acylpeptide hydrolase from porcine brain was found to be potently inhibited by dichlorvos (20-min IC(50) value of 118.7 +/- 9.7 nM).